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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Advances in contraception 9 (1993), S. 83-91 
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resumé Les études portant sur la sáreté de la contraception intra-utérine sont en général fondées sur des études ne reflètant pas les changements dans les pratiques cliniques intervenus au cours des années et se rapportent à de nombreux types de DIU qui ne sont plus utilisés. Les études concernant les insertions de Multiload 375 et Copper T 380 effectuées depuis 1980, qui d'ailleurs reflètent mieux la pratique clinique actuelle, indiquent que ces DIU offrent un haut niveau de protection contre les grossesses et qu'ils sont associés à de faibles pourcentages de complications. S'agissant de la sûreté des DIU, il y a lieu de réévaluer l'opinion clinique actuelle à la lumière des résultats positifs obtenus avec ces dispositifs dans ce domaine.
    Abstract: Resumen Los estudios relativos a la seguridad de la anticoncepción intrauterina suelen basarse en estudios que no reflejan los cambios en las prácticas clínicas ocurridos con el correr del tiempo y que incluyen muchos tipos de DIU que ya no se utilizan. Los estudios relativos a las inserciones del Multiload 375 y Copper T 380 realizados después de 1980, y que reflejan mejor la práctica clínica actual, indican que estos DIU ofrecen un alto nivel de protección contra los embarazos y están asociados con bajos porcentajes de complicationes. En lo que respecta a la seguirdad de los DIU, es necesario evaluar nuevamente la opinión clínica actual a la luz de los resultados positivos obtenidos con estos dispositivos.
    Notes: Abstract Reviews of the safety of intrauterine contraception usually are based on studies that do not reflect changes in clinical practice that have occurred over time, and that include many types of IUDs that are no longer used. Studies of insertions of the Multiload 375 and Copper T 380 performed since 1980, which more accurately reflect current clinical practice, show that these IUDs provide a high level of protection against pregnancy and are associated with low rates of complications. Current clinical opinion regarding the safety of IUDs needs to be reassessed in light of the positive safety record of these IUDs.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The structural investigation of the products arising from 28 days incubation of albumin with high glucose concentration and further enzymatic hydrolysis has been carried out by means of high-performance liquid chromatography/mass spectrometry (HPLC/MS) under plasmaspray conditions. By this approach many different compounds have been detected, and for most of them, possible structures have been proposed on the basis of literature data and molecular weight assignments.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 6 (1992), S. 717-718 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Chemical weapons use, although prohibited by the 1925 Geneva Protocol, has been reported in several armed conflicts including the Iran/Iraq war. The use of these weapons during this conflict and the concern over possible use of chemical warfare (CW) agents during the Persian Gulf war has heightened international awareness and prompted many nations to pursue with incresed vigour the signature of a new Chemical Weapons Convention. The most recent draft of the Chemical Weapons Convention contains a number of provisions aimed at developing a treaty that will enable nations to ensure compliance by all signatory nations. Compliance monitoring will be required in a number of scenarios, including the verification of alleged use, the storage and destruction of chemical weapons stocks and ensuring that industrial sites are not illegally producing CW agents. It follows from this draft treaty that compliance monitoring will require a high level of sophisticated analytical support to ensure the establishment of an enforceable treaty. The United Nations Conference on Disarmament therefore formed a multi-national Technical Group on Instrumentation to address the analytical challenges confronting signatory nations.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 155 (1993), S. 399-407 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Regulation of polyamine transport in murine L1210 leukemia cells was characterized in order to better understand its relationship to specific intracellular polyamines and their analogs and to quantitate the sensitivity by which it is controlled. Up-regulation of polyamine uptake was evaluated following a 48-hr treatment with a combination of biosynthetic enzyme inhibitors to deplete intracellular polyamine pools. The latter declined gradually over 48 hr and was accompanied by a steady increase in spermidine (SPD) and spermine (SPM) transport as indicated by rises in Vmax to levels ∼4.5 times higher than control values. Restoration of individual polyamine pools during a 6-hr period following inhibitor treatment revealed that SPD and SPM uptake could not be selectively affected by specific pool changes. The effectiveness of individual polyamines in reversing inhibitor-induced stimulation of uptake was as follows: putrescine 〈 SPD 〈 SPM = the SPM analog, N1, N12-bis(ethyl)spermine (BESPM). In contrast to stimulation of transport, down-regulation by exogenous polyamines or analogs occurred rapidly and in response to subtle increases in intracellular pools. Following a 1-hr exposure to 10 μM BESPM, Vmax values for SPD and SPM fell by 70%, whereas the analog pool increased to only 400-500 pmol/106 cells - about 15-20% of the total polyamine pool (∼2.8 nmol/106 cells). SPM produced nearly identical regulatory effects on transport kinetics. Both BESPM and SPM were even more effective at down-regulating transport that had been previously stimulated four to fivefold by polyamine depletion achieved with enzyme inhibitors. A dose response with BESPM at 48 hr revealed a biphasic effect on uptake whereby concentrations of analog 〈 3 μM produced an increase in SPD and SPM Vmax values, whereas concentrations 3 μM and higher produced a marked suppression of these values. Cells treated with 3 μM BESPM for 2 hr and placed in analog-free medium recovered transport capability in only 3 hr. Thus, whereas stimulation of polyamine transport is a relatively insensitive and slowly responsive process that tends to parallel polyamine depletion, down-regulation of polyamine transport by exogenous polyamines and analogs and its reversal are rapidly responsive events that correlate with relatively small (i.e., 15-20%) changes in intracellular polyamine pools.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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