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  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of ranitidine on acetaminophen-induced hepatotoxicity in dogs (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 385-391 
    Details
    ISSN: 1573-2568
    Keywords: hepatotoxicity ; acetaminophen ; ranitidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of ranitidine administration upon the hepatotoxic effect produced by a multidose acetaminophen administration regimen was examined. Seventy-two dogs received three subcutaneous injections of acetaminophen (750, 200, 200 mg/kg body wt) in DMSO (600 mg/ml) at time zero, 9 hr later, and 24 hr after the first dose. Ten control animals (group I) were not given ranitidine, the remaining 62 dogs received an intramus-cular injection of ranitidine 30 min before each acetaminophen dose. Three different doses of ranitidine were used (mg/kg body wt): 50 mg, group II (33 dogs); 75 mg, group III (14 dogs); 120 mg, group IV (15 dogs). Ranitidine reduced the expected acetaminophen-induced hepatoxicity in a dose-response manner. Moreover, a significant correlation was found between the ranitidine dose and the survival rate, as evidenced by transaminase levels in the serum and histology of the liver. This model of fulminant hepatic failure induced by acetaminophen and its modulation with ranitidine provides clinical investigators with a research tool that will be useful in the future investigation of putative medical and surgical therapies being investigated for use in the clinical management of fulminant hepatic failure. Because of the size of the animal used in this model, frequent and serial analyses of blood and liver were available for study to determine the effect of therapy within a given animal as opposed to within groups of animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537419
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    An integrated system for forecasting Arno River flash floods (1992)
    Springer
    Natural hazards 5 (1992), S. 179-197 
    Details
    ISSN: 1573-0840
    Keywords: Flood hazard ; risk forecasting ; expert systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A system for effectively forecasting flash floods of the Arno River (Tuscany, Italy) should provide a flood warning with 10–12 h of lead time, primarily in order to evacuate the city of Florence. This goal may be achieved by acquiring and processing meteorological and hydrological data in real-time and, accordingly, by releasing alarms at different levels of reliability and concern. Through the application of both procedural language and expert system techniques, a prototype was developed which can readily handle a variety of relevant information and make predictions on flood hazard in Florence. The system was fairly successfully tested by processing simple meteorological data which enable a 24 hour forewarning to be released.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00127005
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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