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  • 1
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    Leyden : Periodicals Archive Online (PAO)
    Numen. 40 (1993) 99 
    ISSN: 0029-5973
    Topics: History , Theology and Religious Studies
    Notes: Book reviews
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 102 (1990), S. 379-382 
    ISSN: 1432-2072
    Keywords: Paroxetine ; Amitriptyline ; Electrocardiogram ; Blood pressure ; Systolic time intervals ; Plasma drug concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind clinical study, electrocardiogram, blood pressure and systolic time intervals were measured in 40 depressive patients treated with either paroxetine (30 mg/day) or amitriptyline (150 mg/day) for 6 weeks. While amitriptyline significantly increased the heart rate, the QTc interval and the PEP/LVET ratio, paroxetine did not alter any of the cardiovascular parameters measured.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-601X
    Keywords: 25.40.Sc ; 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have studied the fragmentation of Au projectiles interacting with targets of C, Al and Cu at an incident energy ofE/A=600 MeV. The employed inverse kinematics allowed a nearly complete detection of projectile fragments with chargeZ≧2. The recorded fragmentation events were sorted according to three observables, the multiplicityM lp of light charged particles, the largest atomic numberZ max within an event, and a new observable,Z bound, representing the sum of the atomic numbersZ of all fragments withZ≧2. Using these observables, the impact parameter dependence of the fragmentation process was investigated. For all three targets, a maximum mean multiplicity of 3 to 4 intermediate mass fragments (IMFs) is observed. The corresponding impact parameters range from central collisions for theC target to increasingly peripheral collisions for the heavier targets. It is found that the correlation between the IMF multiplicity andZ bound, extending from evaporation type processes (largeZ bound) to the total disassembly of the projectile (smallZ bound), is independent of the target nucleus. This universal behaviour may suggest an — at least partial — equilibration of the projectile fragment prior to its decay.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-601X
    Keywords: 25.70.-z ; 25.70.Lm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Events with 2, 3 and 4 heavy-fragments (A≧20) have been detected in the reactions100Mo+100Mo atE/A =18.7, 23.7 MeV and120Sn+120Sn atE/A=18.4 MeV. The experiments were performed with an array of 12 detectors which together covered a large fraction of the forward hemisphere and allowed a high detection efficiency for these events. Masses and energies of all fragments have been reconstructed by means of an improved version of the kinematic coincidence method. The probabilitiesP 3 andP 4 of producing 3- and 4-body events were found to depend mainly on the dissipated energy rather than on the bombarding energy, thus indicating that their origin lies more in the decay properties of the excited fragments than in the dynamics of the interaction. Emission of light particles from the composite system is shown to become more relevant with increasing bombarding energy and may explain the drop of theP 3 andP 4 curves at high energy losses. Small deviations of theP 3 andP 4 curves at 23.7A · MeV from those at lower bombarding energies were used to estimate the amount of a possible pre-equilibrium light particle emission as a function of impact parameter.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0584
    Keywords: Chronic myelogenous leukemia ; Type-I interferon ; Interleukin 1 receptor antagonist protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It was the aim of this study to investigate the antileukemic activities of recombinant interferon beta (rIFN beta) in chronic-phase CML in vitro and in vivo. Nine patients in the early chronic-phase of CML were treated in a phase-II trial with escalating doses of rIFN beta. In parallel, antiproliferative and immunomodulatory activities of rIFN beta and rIFN alpha 2b were studied in vitro. rIFN beta exhibited a significantly higher antiproliferative activity on hematopoietic progenitor cells of CML patients in vitro than rIFN alpha 2b. In contrast, only very limited clinical antileukemic efficacy of rIFN beta was observed. None of the patients achieved a complete or partial hematologic response (0% response rate, 0–36% 95 C.I.). Primary resistance of CML patients to rIFN beta treatment was caused neither by antibody formation against the recombinant material nor by deficient IFN receptor targeting and/or signaling: Induction of serum levels of beta-2-microglobulin (Β-2-m) and neopterin after administration of rIFN beta was comparable to that seen after administration of rIFN alpha. However, rIFN beta treatment less effectively induced biosynthesis of interleukin-1 receptor antagonist protein (IL-1-Ra) than rIFN alpha 2b. Thus, we conclude that rIFN beta at doses up to 12 MU/day s.c. is ineffective for treatment of chronic-phase CML. Further investigations into divergent biologic responses to various type-I interferons might help to elucidate mechanisms crucial for IFN action in patients with CML.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2622
    Keywords: Biosynthesis inhibitors ; chicken ; dopamine ; electrooculogram ; lectroretinogram ; 5-hydroxytryptamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The involvement of catecholaminergic and indoleaminergic systems in the modulation of the standing potential of the eye was tested in chickens by means of an indirect electrooculography method and direct current electroretinogram recordings. D,L α- monofluoromethyl dopa (MFMD), 50 and 100 nmol), a highly specific inactivator of aromatic L-amino acid decarboxylase, was injected intravitreally. This treatment is known to induce a selective and irreversible blockade of dopamine and 5-hydroxytryptamine biosynthesis. Five hours after drug injection an important increase in the standing potential appeared. The light peak was delayed by about 5 min but its amplitude was unchanged. The return of the standing potential to basal value during maintained illumination was delayed by 5–10 min. The time course of the dark trough was not modified. The intensity-voltage functions were also studied for the various electroretinogram components, 5 hr after MFMD. The voltage of the b-wave was reduced (by 65% with the highest intensity), while the other components were little affected. Substantial reduction in dopamine and 5-hydroxytryptamine concentrations were found in treated retinas. These data, together with previous results, suggest that the standing potential of the chicken eye may be modulated by a balance between catecholamine and indoleamine systems.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Chemical and petroleum engineering 30 (1994), S. 86-90 
    ISSN: 1573-8329
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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