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  • 1
    Electronic Resource
    Electronic Resource
    A New Pentacyclic Triterpene Acid from Lantana indica (1991)
    s.l. : American Chemical Society
    Journal of natural products 54 (1991), S. 755-758 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50075a003
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  • 2
    Electronic Resource
    Electronic Resource
    Acid Hydrolysis of .kappa.-Carrageenan in a Batch Reactor: Stochastic Simulation of Change of Molecular Weight Distribution with Time (1994)
    s.l. : American Chemical Society
    Biotechnology progress 10 (1994), S. 389-397 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00028a008
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  • 3
    Electronic Resource
    Electronic Resource
    Nonequilibrium thermodynamics of electrokinetic phenomena (1993)
    s.l. : American Chemical Society
    Chemical reviews 93 (1993), S. 1945-1990 
    Details
    ISSN: 1520-6890
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/cr00022a001
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  • 4
    Electronic Resource
    Electronic Resource
    Source spectra and RMS acceleration of Mexican subduction zone earthquakes (1990)
    Springer
    Pure and applied geophysics 133 (1990), S. 447-474 
    Details
    ISSN: 1420-9136
    Keywords: Source spectra ; RMS acceleration ; Mexican earthquakes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Strong motion (SM) data of six Mexican subduction zone earthquakes (6.4≤M S≤8.1) recorded near the epicentral zone are analyzed to estimate their far-field source acceleration spectra at higher frequencies (f≥0.3 Hz). Apart from the usual corrections such as geometrical spreading (1/R), average radiation pattern (0.6), free surface amplification (a factor of 2), and equal partitioning of the energy into two orthogonal horizontal components (a factor of 1/ $$\sqrt 2 $$ ), the observed spectra are corrected for a frequency dependentQ(Q=100f), a site dependent filter (e −πkf ), and amplification ofS waves near the surface (a factor of about 2 atf≥2Hz). We takeR as the average distance from the rupture area to the site. If we model the high frequency plateau (f≥1 Hz) of the source spectra, by a point source ω−2-model, and interpret them in terms of Brune's model we obtain δσ between 50 and 100 bars for all earthquakes. The low-frequency broadband teleseismicP wave spectra, corrected witht *=1.0 s, agrees within a factor of two with SM source spectra near 1 Hz. The ω−2-model is inadequate to explain the observed source spectra in a broad frequency range; these resemble spectra given byGusev (1983) with some differences. SM source acceleration spectra require significant corrections to explain observed spectra and RMS acceleration (arms) (a) at farther coastal sites for extended sources due to directivity effect and (b) at inland sites (100≤R≤200 km) because of unaccounted path and site amplification and/or invalidity of body-wave approximation. The observed spectra and arms at these sites are significantly greater than the predicted values from the estimated source spectra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00878000
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  • 5
    Electronic Resource
    Electronic Resource
    Human breast cancer: frequent p53 allele loss and protein overexpression (1993)
    Springer
    Human genetics 〈Berlin〉 90 (1993), S. 635-640 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors (43%) was detected with the variable number of tandem repeats (VNTR) probe YNZ22 mapping at 17p13.3 close to the p53 locus at 17p13.1. Among 19 tumors informative for both probes allele loss at 17p13.3 never occurred without p53 involvement. These data suggest, that p53 is the target of 17p13 allelic deletions in human breast cancer. Immunohistochemistry showed overexpression of the p53 protein in 25 of 50 cases (50%) presumably reflecting activating point mutations. Overexpression was not correlated with allele loss but seemed to be closely related to the presence of point mutations in this study. No homozygous deletions or rearrangements of the p53 gene were detected. This would argue for an important role of heterozygous p53 mutations in human breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202481
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  • 6
    Electronic Resource
    Electronic Resource
    A method for transforming lymphocytes from very small blood volumes suitable for paediatric samples (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 615-616 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Permanent lymphoblastoid cell lines are important in the molecular analysis and characterization of human genetic disorders, when immortalized cells must be banked for future diagnostic or research purposes. However, routine methods for transformation using Epstein-Barr virus (EBV) require blood volumes that may be difficult to collect from clinically compromised neonates and small children. Here we report a modified transformation procedure utilizing blood samples of small volume (less than 1.0ml), which we have found to be particularly useful for the immortalization of lymphocytes destined for future molecular genetic studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201551
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  • 7
    Electronic Resource
    Electronic Resource
    Mosaicism in 45,X Turner syndrome: does survival in early pregnancy depend on the presence of two sex chromosomes? (1992)
    Springer
    Human genetics 〈Berlin〉 88 (1992), S. 288-294 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytogenetic and molecular genetic findings in 91 patients with Turner syndrome are reported. In 87 patients, chromosome studies were carried out both in lymphocyte and fibroblast cultures. Mosaicism was demonstrated in 58 of these patients (66.7%), whereas only 18 (20.7%) were apparent non-mosaic 45,X, and 11 patients (12.6%) showed non-mosaic structural aberrations of the X chromosome. Among the mosaic cases 16 (18.4% of all patients) displayed a second cell line containing small marker chromosomes. The association of Y-specific chromosomal material with the presence of marker chromosomes was demonstrated in 6 out of 7 mixoploid fibroblast cell lines by polymerase chain reaction amplification and by Southern-blot analysis. The observation of ring formation and morphological variability in vivo and in vitro, and the continous reduction in the percentage of cells containing marker chromosomes in longterm cultivation experiments indicated an increased instability of marker chromosomes. The findings suggest that in vivo selection of structurally altered sex chromosomes exists. Thus, the observation of apparent non-mosaic 45,X chromosomal complements in liveborn individuals with Turner syndrome does not contradict the hypothesis that some degree of mosaicism is necessary for survival in early pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197261
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  • 8
    Electronic Resource
    Electronic Resource
    Distribution of ADH2 and ALDH2 genotypes in different populations (1992)
    Springer
    Human genetics 〈Berlin〉 88 (1992), S. 344-346 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197271
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  • 9
    Electronic Resource
    Electronic Resource
    PstI identifies biallelic DNA polymorphism of the human casein kinase 2α gene (CSNK2A1) (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 474-474 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract cDNA probe of the casein kinase 2α subunit gene detects a biallelic PstI polymorphism. This restriction fragment length polymorphism is the first known genetic marker of this gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201680
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  • 10
    Electronic Resource
    Electronic Resource
    Rhizobium sp. exopolysaccharide production, nodulation, and acetylene reduction activity (N2-fixation) in pigeon pea (Cajanus cajan L.) (1991)
    Springer
    Biology and fertility of soils 11 (1991), S. 30-33 
    Details
    ISSN: 1432-0789
    Keywords: Rhizobium spp. ; Bradyrhizobium spp. ; Cajanus cajan ; Pigeonpea ; Exopolysaccharide ; Nodulation ; Acetylene reduction assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary There was no correlation between the quantity of exopolysaccharide produced and acetylene reduction activity by Rhizobium spp. or by Bradyrhizobium spp. (Cajanus). The exopolysaccharide-defective mutants of Rhizobium sp. strain P 116 either failed to nodulate or showed a decrease in effectiveness. The deficiency in exopolysaccharide production was corrected by the addition of purified exopolysaccharide from the parent strain, or from Bradyrhizobium sp. strain P 149 or S24 isolated from pigeonpea (Cajanus cajan) and mungbean (Vigna radiata), respectively. However, the nodules so formed were not fully effective compared to those formed by the parent strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335830
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