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  • 1
    Electronic Resource
    Electronic Resource
    Pancreatic cytokeratin: an antigen of pancreatic exocrine cell autoantibodies in Type 1 (insulin-dependent) diabetes mellitus (1990)
    Springer
    Diabetologia 33 (1990), S. 363-370 
    Details
    ISSN: 1432-0428
    Keywords: Pancreatic exocrine cell antibodies ; cytokeratin ; Type 1 (insulin-dependent) diabetes mellitus ; islet cell antibodies ; pancreatic exocrine cells ; pancreatic islet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autoantibodies reacting with human pancreatic exocrine cells were investigated by immunofluorescent techniques in 107 patients with Type 1 (insulin-dependent) diabetes mellitus, 20 first-degree relatives of the Type 1 diabetic patients, 347 patients with Type 2 (non-insulin-dependent) diabetes, 34 with alcoholic pancreatitis, 26 with rheumatoid arthritis and 107 normal control subjects. Both immunoblotting analysis and double-immunostaining methods were used to characterize the antigens targeted by the pancreatic exocrine cell autoantibodies. Sera positive for human pancreatic exocrine cell cytoplasm, producing a “fine fibrillar” pattern, were found in 21% (23/107) of the Type 1 diabetic patients. The autoantibodies were present in 39% (15/38) of Type 1 diabetic patients diagnosed within 3 months, and the prevalence decreased with duration of diabetes. The antibodies were of the IgM class in 87% (13/15) of recent-onset Type 1 diabetes cases, but IgG-autoantibodies became more prevalent with increasing duration of diabetes. Three out of 347 (0.9%) Type 2 diabetic patients and 4 of 20 (20%) first-degree relatives of Type 1 diabetic patients had autoantibodies targeted against pancreatic exocrine cells. None of the patients with alcoholic pancreatitis or rheumatoid arthritis and none of the control subjects had these antibodies. Immunoblotting analysis and double-immunostaining demonstrated that the autoantibodies reacted with 40 kilodalton cytokeratin in pancreatic exocrine cell cytoplasm. The antibody was absorbed by the Triton X-100-insoluble fraction of pancreatic extract. These results indicate the presence of distinct autoantibodies to pancreatic exocrine cells in Type 1 diabetes. This suggests the provocative concept that the cytoskeletal system of pancreatic exocrine cells is involved in the pathogenetic process of Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404641
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  • 2
    Electronic Resource
    Electronic Resource
    Translocation of protein kinase C α and ζ in rat glomerular mesangial cells cultured under high glucose conditions (1994)
    Springer
    Diabetologia 37 (1994), S. 838-841 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetic nephropathy, glomerular mesangial cells, protein kinase C, isoenzymes, high glucose.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activities and expression of protein kinase C isoenzymes were examined in glomerular mesangial cells cultured under high glucose conditions. Exposure of cells to high glucose concentrations (27.8 mmol/l) for more than 3 days resulted in a significant elevation of protein kinase C activities in the membrane fraction. Of the protein kinase C isoenzymes, the levels of protein kinase C α significantly increased in the membrane fraction after 3 days of exposure to glucose, and protein kinase C ζ increased after 5 days of exposure. Levels of protein kinase C δ and ɛ remained unchanged and protein kinase C β and γ were not detected. These results indicate that protein kinase C α and ζ are translocated under high glucose conditions possibly through different mechanisms. [Diabetologia (1994) 37: 838–841]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404342
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  • 3
    Electronic Resource
    Electronic Resource
    Translocation of protein kinase C α and ζ in rat glomerular mesangial cells cultured under high glucose conditions (1994)
    Springer
    Diabetologia 37 (1994), S. 838-841 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic nephropathy ; glomerular mesangial cells ; protein kinase C ; isoenzymes ; high glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activities and expression of protein kinase C isoenzymes were examined in glomerular mesangial cells cultured under high glucose conditions. Exposure of cells to high glucose concentrations (27.8 mmol/l) for more than 3 days resulted in a significant elevation of protein kinase C activities in the membrane fraction. Of the protein kinase C isoenzymes, the levels of protein kinase C α significantly increased in the membrane fraction after 3 days of exposure to glucose, and protein kinase C ζ increased after 5 days of exposure. Levels of protein kinase C δ and ε remained unchanged and protein kinase C Β and γ were not detected. These results indicate that protein kinase C α and ζ are translocated under high glucose conditions possibly through different mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404342
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  • 4
    Electronic Resource
    Electronic Resource
    A model for the larval migration of the Japanese eel: roles of the trade winds and salinity front (1994)
    Springer
    Marine biology 119 (1994), S. 185-190 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A model that helps explain the mysterious long-distance migration of the Japanese eel (Anguilla japonica) is presented, based on oceanographic observations, satellite buoy drift experiments, and samplings of eel larvae taken in 1991. The trajectory of a 150 m depth buoy relased in the spawning area strongly suggests that A. japonica larvae spawned just south of the salinity front are transported westward by the North Equatorial Current (NEC). The larvae are then thought to be entrained into the Mindanao Current flowing southward along the Philippine Islands where A. japonica juveniles are scarcely distributed. These controversial results lead to the assumption that eel larvae are transferred from the NEC to the northward flowing Kuroshio, which distributes the eel larvae to the growth habitats of eastern Asia. In this eel larvae transfer model, a northward Ekman transport caused by trade winds plays an important role in explaining the wind-induced northward shift of the larvae together with the onset of diel vertical migration. Assuming that leptocephali greater than 20 mm initiate the vertical migration, a westward wind velocity greater than 5 to 10 m s-1 should be high enough to diminish the southward current velocity. When the physical and geophysical conditions — such as the salinity front for spawning activity, the water tunnel for westward larval transport, the Ekman transport by the trade wind for transfer of the larvae from the NEC to the Kuroshio, and the strong velocity of the Kuroshio for rapid transport to growth habitats — are well matched with the timing of the onset of vertical migration, large-scale eel migration could result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349555
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  • 5
    Electronic Resource
    Electronic Resource
    Efficacy of disopyramide in conversion and prophylaxis of post-thyrotoxic atrial fibrillation (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 215-219 
    Details
    ISSN: 1432-1041
    Keywords: Atrial fibrillation ; disopyramide ; thyrotoxicosis ; cardioversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Rhythm conversion in patients with post-thyrotoxic atrial fibrillation (AF) has been performed with disopyramide in order to evaluate the conversion rate and to test its effect on the maintenance of sinus rhythm after cardioversion. The duration of AF ranged from 9 to 122 months (mean 31.8 months). Of 81 patients, 12 (15%) with relatively short duration AF were converted to sinus rhythm with disopyramide. The remaining 69 patients required DC cardioversion, which restored sinus rhythm in 58 patients. The 58 DC-converted patients were divided into two groups: a disopyramide group (D group) and a non-disopyramide group (non-D group). The D group received disopyramide 300 mg per day for 3 months after DC cardioversion and the non-D group did not receive anti-arrhythmic drugs. During the early observation period, only one patient relapsed in the D group into AF, but 5 successive patients in the non-D group reverted to AF, forcing discontinuation of the non-D protocol. A second DC cardioversion performed on 3 of those 5 patients was followed by maintenance therapy with disopyramide 300 mg per day, and they remained in sinus rhythm. With the inclusion of those three subjects, sinus rhythm was still present in 44 of the total of 58 patients converted by DC (76%) at the time of follow-up (64 months). Thus, disopyramide was effective in rhythm conversion and it was essential for the maintenance of sinus rhythm after cardioversion in patients with post-thyrotoxic AF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315198
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  • 6
    Electronic Resource
    Electronic Resource
    Meningiomas: Correlation between MRI characteristics and operative findings including consistency (1994)
    Springer
    Acta neurochirurgica 129 (1994), S. 39-46 
    Details
    ISSN: 0942-0940
    Keywords: Tumour consistency ; meningiomas ; MRI ; T 2-weighted image
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The findings on magnetic resonance imaging (MRI) in 73 surgically verified intracranial meningiomas were correlated with their histology and consistency during resection. T 1-weighted imaging was least useful since most of the tumours were iso-intense, similar to cortical grey matter regardless of histology or tumour consistency. The signal intensity on T 2-weighted images was found to best correlate with both the histology and consistency of the meningioma. Generally, the low intensity portion of the tumour on T 2-weighted images indicated a more fibrous and harder character, while the higher intensity portions indicated a more soft character. Most of the fibroblastic meningiomas showed the features of a hard tumour while angioblastic tumours showed the features of soft tumours. Tumours predicted to be harder on MR imaging generally took longer to resect than softer ones, and this relationship was shown best for the larger tumours. Using linear regression analysis, it appears that operative time for soft tumours is more affected by factors other than tumour consistency. Blood loss during surgery was also unrelated to the consistency of the tumour. These results suggest that the histology and consistency of meningiomas may be predictable from findings on T 2-weighted imaging, and this may also predict the difficulty and time required for resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400871
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  • 7
    Electronic Resource
    Electronic Resource
    Morphological and functional alterations of the hypothalamic-pituitary system in brain death with long term bodily living (1992)
    Springer
    Acta neurochirurgica 115 (1992), S. 31-36 
    Details
    ISSN: 0942-0940
    Keywords: Brain death ; hypothalamic hormone ; hypothalamic-pituitary system ; pituitary-hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypothalamic hormones as well as anterior pituitary hormones were detected in the peripheral plasma after the diagnosis of brain death. It is possible that residual hypothalamic tissue was functioning after satisfying the usual criteria of total brain death. To examine this possibility, endocrinological and morphological alterations of the hypothalamic-pituitary system was evaluated in 28 brain dead patients. Intrinsic ADH was depleted in the plasma shortly after the diagnosis of brain death. Anterior pituitary hormones were initially detected in all patients, but gradually disappeared. The direct TRH (thyrotropin releasing hormone) stimulation to the anterior lobe was responded to well. Morphological studies showed a partial necrosis of the anterior lobe and the preservation of the posterior lobe for as long as a week. These data prove that the pituitary is partially preserved after brain death. LH-RH (luteinizing hormone releasing hormone) was detected in the peripheral plasma of all patients and GRF (growth hormone releasing factor) was detected in half of the patients for as long as 15 days, but autopsy revealed the fact that the brain tissue including the hypothalamus became extensively necrotic after the sixth day of brain death. In order to solve this controversy it is proposed that these hormones originate from extracranial tissues such as pancreas. The detection of hypothalamic hormones after the diagnosis of brain death therefore is not contradictory to the concept of total brain death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400587
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  • 8
    Electronic Resource
    Electronic Resource
    PLASMA ADENOSINE CONCENTRATIONS ARE ELEVATED IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 19 (1992), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Plasma levels of adenosine were measured in unrestrained, conscious spontaneously hypertensive rats (SHR) to examine the potential role of adenosine, a naturally occurring substance with profound cardiovascular actions, in cardiovascular regulation in these genetically hypertensive rats.2. We employed a specific and sensitive assay for adenosine based on fluorescent determination of adenine compounds by high performance liquid chromatography.3. Plasma adenosine concentrations were significantly higher in 13 week old SHR with hypertension than in Wistar-Kyoto rats (0.165±0.022 vs 0.096±0.008 μmol/L; P 〈 0.05).4. These observations indicate that plasma adenosine levels are increased in conscious SHR with established hypertension, and also suggest that adenosine may be at least partly involved in the pathophysiology of high blood pressure in SHR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1992.tb00505.x
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  • 9
    Electronic Resource
    Electronic Resource
    Perpendicular magnetic anisotropy in Pt/Fe multilayers : 35th annual conference on magentism and magnetic materials San Diego, California (USA) 29 Oct − 1 Nov 1990 (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 5658-5660 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Perpendicular magnetic anisotropy (K⊥) and related magnetic properties in Pt/Fe multilayers [compositionally modulated multilayer films (CMFs)] are investigated. It is found that Pt/Fe CMFs with about an 18-A(ring) Pt layer and Fe layer below 5 A(ring) become perpendicularly magnetized films. Surface magnetic anisotropy (Ks) and volume anisotropy (Kv) are 0.46 erg/cm2 and about − 2 × 107 erg/cm3 at room temperature, respectively. The Ks is almost equivalent to that of Pt/Co CMFs and increases with decreasing temperature. The absolute value of Kv, however, is much larger than that of the Pt/Co system. The effective magnetic anisotropy (K⊥ eff) of [Fe(4.7 A(ring))/Pt(18.5 A(ring))]80 CMF changes from positive to negative at T(approximately-equal-to)200 K with decreasing temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347927
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  • 10
    Electronic Resource
    Electronic Resource
    Erratum: "Magnetic circular dichroism at the M2,3 edges in three-dimensional transition metals and their compounds'' [Rev. Sci. Instrum. 63, 1371 (1992)] (1992)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 63 (1992), S. 3529-3529 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1143796
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