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  • 1990-1994  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Crossreactivity of IgE antibody against Dermatophagoides farinae with Limulus polyphemus agglutinin (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Crossreactivity of IgE antibody against Dermatophagoides farinae (Der f) with Limulus polyphemus agglutinin (LPA) was examined using RAST and immunoblot analysis. Of 40 Der f-sensitive asthmatic patients, 28 revealed a positive RAST reaction to LPA, while none of 20 Der f-insensitive hay fever patients showed this reaction. LPA-specific RAST levels of the 40 asthmatic patients correlated with their Der f-specific levels. The RAST reactivity to LPA was competitively inhibited by the addition of either soluble Der f or LPA, but not by the specific inhibitory sugar of sialic acid. LPA could also induce histamine release from leucocytes of Der f-sensitive asthmatic patients. IgE immunoblot analyses showed that the positive RAST sera for LPA had a strong IgE binding activity to the 30 kDa and 80 kDa components of DER F body extract, whereas gel filtration studies showed that the high molecular weight fractions above 150 kDa retained antigenic constituents associated with IgE reactivity to LPA. These results suggest that the antigenic materials of Dermatophagoides mites share some determinants with the haemagglutinin of horseshoe crabs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00252.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Relation between bronchial responsiveness to methacholine and levels of IgE antibody against Dermatophagoides farinae and serum IgE in asthmatic children (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The relation between non-specific bronchial responsiveness and allergic sensitivity was evaluated in children with asthma. Bronchial responsiveness was determined by methacholine inhalation challenge test, and was expressed as a provocative concentration of methacholine causing a 20% fall in FEV1 (PC20). RAST titre for Dermatophagoides farinae and serum IgE level were evaluated as parameters of allergic sensitivity. When the PC20 vaiues, RAST titres for D. farinae. and serum IgE levels of 47 asthmatic children and 16 normal controls were compared. the asthmatic children had significantly lower PC20 values and higher D. farinae-RAST titres and serum IgE levels than the normal controls. The correlation analyses in 47 asthmatic children have shown that there is no significant correlation between PC20 values and RAST titres for D. farinae (r= 0.04. P 〉 0.1) or between PC20 values and serum IgE levels (r= 〈 0.03 P 〉 0.1). These results suggest thaty although both bronchial hyperresponsiveness and allergic sensitizalion may be in some way related to one another in children with asthma, the magnitude of allergie sensilization does not influence the degree of the non-specific bronchial responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb00353.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A comparative study of linear measurement of the brain and three-dimensional measurement of brain volume using CT scans (1993)
    Springer
    Pediatric radiology 23 (1993), S. 165-168 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parameters of linear measurement were compared with actual brain volume to assess the significance of linear measurements as indices of atrophy in 31 neurologically normal children and 22 neurologically abnormal children. Brain volume was established by means of an image-analyzing system using contiguous CT scans. The parameters or indices estimated were: (1) the maximum transverse width of both hemispheres, (2) the maximum longitudinal length of both hemisphere, (3) the maximum frontal subarachnoid space, (4) the maximum width of the interhemsipheric fissure, (5) the maximum width of the Sylvian fissure, (6) Evan's ratio, (7) the maximum width of the third ventricle, (8) the cella media index, (9) the maximum width of the fourth ventricle. In neurologically normal children, the maximum transverse width of both hemispheres, the maximum longitudinal length of both hemispheres, the maximum width of the interhemispheric fissure and the maximum width of the Sylvian fissure correlated significantly with the combined volume (CV) of both hemispheres and basal ganglia. In particular, the maximum transverse width of both hemispheres and the maximum longitudinal length of both hemispheres had a high correlation. In neurologically abnormal children the maximum transverse width of both hemispheres and the maximum width of the interhemispheric fissure were significantly correlated with the CV of both hemispheres and basal ganglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013822
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Volumetric quantification of brain volume in children using sequential CT scans (1990)
    Springer
    Neuroradiology 32 (1990), S. 300-303 
    Details
    ISSN: 1432-1920
    Keywords: Brain volume ; Development ; CT scan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We devised a three dimensional method for the accurate measurement of brain volume and applied it to 32 neurologically normal children, 7 children with only mental retardation and 15 children with both mental retardation and motor disturbance. In the group of neurologically normal children, the total brain volume increased from 723 cm3 to 1407 cm3 in order of age. The correlation ratio between the total brain volume and age was significant (P〈0.0001). The values of the total brain volume and the developmental curve were similar to those of the total brain weight of normal children previously reported. The combined volume of the cerebellum, the midbrain, the pons and the medulla also increased from 76 cm3 to 200 cm3 in a manner similar to that of the total brain. The correlation between total brain volume and head circumference was significant (P〈0.0001). In the group of children with mental retardation, the total brain volume was relatively smaller than that of neurologically normal children. In the group of the children with mental retardation and motor disturbance, 10 out of 15 cases showed values below — 2 SD of those of neurologically normal children. The values of the total brain volume were each less than — 3 SD in 3 cases whose head circumferences were each more than — 3 SD. Our method for the direct measurement of brain volume based on serial CT scans may be useful for the accurate examination of brain development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593049
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    Paper (German National Licenses)
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