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  • 1
    Electronic Resource
    Electronic Resource
    Grain Boundary Migration with Solute Segregation under Electron Irradiation (1993)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 126-128 (Jan. 1993), p. 197-200 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/59/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.126-128.197.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Iron-Phosphorus Interaction in Si (1993)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 143-147 (Oct. 1993), p. 1257-1262 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.143-147.1257.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Copper metabolism in the LEC rat: Involvement of induction of metallothionein and disposition of zinc and iron (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 1060-1063 
    Details
    ISSN: 1420-9071
    Keywords: LEC rat ; copper ; metallothionein ; ceruloplasmin ; zinc ; iron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Cu concentration was about 40 times higher in the liver of LEC (Long-Evans with a cinnamon-like coat color) rats aged 77 days (227.5±21.6 μg/g liver) than in Fischer rats (5.2±0.1 μg/g liver). However, in the kidney and brain of the LEC rats, Cu concentrations were lower than in these organs of the Fischer rats. Cu concentration in the hepatic metallothionein fraction was about 130 times higher in the LEC rats than in the Fischer rats. The LEC rats showed markedly low concentrations of Cu in the serum and bile. It seems likely that excretion of Cu from the liver into the bile and blood (as ceruloplasmin) is inherently lacking in the LEC rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923342
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  • 4
    Electronic Resource
    Electronic Resource
    Clarke's column in sporadic amyotrophic lateral sclerosis (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 465-470 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Clarke's column ; Bunina body ; Spheroid ; neuronal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological, ultrastructural and morphometrical observations on Clarke's column were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. Bunina bodies were found in the neuronal cytoplasm in 7 of the 12 non-respirator-supported ALS patients and in 3 of the 6 respirator-supported patients. The number of spheroids was significantly higher in the non-respirator-supported patients (P〈0.01) than in the control subjects; however, the number in the respirator-supported patients was about equal to that in the controls. The number of neurons in Clarke's column in the non-respirator-supported ALS patients was not reduced, but in the respirator-supported patients they tended to disappear with time after respiratory support. These findings suggest that Clarke's column neurons are also involved primarily in the disease process in sporadic ALS. However, they may begin to disappear only after the patients require respiratory support.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304464
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistological study of senile brains by using a monoclonal antibody recognizing β amyloid precursor protein: significance of granular deposits in relation with senile plaques (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 260-265 
    Details
    ISSN: 1432-0533
    Keywords: Monoclonal antibody ; β Amyloid protein ; β Amyloid precursor protein ; Senile plaque ; Granular deposits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunochemical analyses revealed that a monclonal antibody Am-3 recognized β amyloid precursor protein (βAPP) in senile plaques extracted from Alzheimer's brain, but did not recognize β amyloid protein. Immunohistochemically, however, the staining pattern of Am-3 in frozen section of Alzheimer's brain was almost the same with that of rabbit polyclonal antibody to β amyloid peptide which could recognize both β amyloid protein and βAPP. In other words, βAPP was present in senile plaques of various types, cerebrovascular amyloid and granular deposits. The granular deposits were 5–10 μm in size and laminarily distributed in the 1st, 3rd and 4th layers of cerebral cortex. They were especially abundant in 1st and 4th layers where senile plaques were usually fewer in number. Although the distribution in the cerebral cortex was different between the senile plaques and the granular deposits, the number of the granular deposits was well correlated with that of senile plaques. The granular deposits were negative in Congo-red birefringence, but contained β amyloid protein as well as βAPP fragment judging from positive staining by both Am-3 and polyclonal antibody to synthetic β amyloid peptide. Thus, they could be regarded as “pre-amyloid”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294643
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular characterization of a JC virus (Sap-1) clone derived from a cerebellar form of progressive multifocal leukoencephalopathy (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 105-112 
    Details
    ISSN: 1432-0533
    Keywords: Polyomavirus JC ; Progressive multifocal leukoencephalopathy (PML) ; Cerebellar PML ; Molecular characterization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by polyomavirus JC (JCV). In the majority of cases of PML the cerebrum is mainly affected (cerebral PML) but on rare occasions lesions are restricted to the cerebellum and brain stem (cerebellar PML). We report a rare cerebellar PML case which occurred in a Japanese patient undergoing prolonged hemodialysis treatment. To understand the molecular basis of the viral tissue tropism, we molecularly cloned JCV DNA and compared it with those of cerebral PML. Of ten clones analyzed nine showed identical fragment patterns after digestion with various restriction endonucleases, and we designated these clones Sap-1. It could be shown that the basic structures of the regulatory regions are similar between Sap-1 and isolates from cerebral PML. Restriction endonuclease mapping analysis was used to examine the genetic relationship between Sap-1 and urine-derived isolates containing the archetypal regulatory sequence. We found that Sap-1 was genetically related to an archetypal JCV isolate in Japan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308469
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  • 7
    Electronic Resource
    Electronic Resource
    The intermediolateral nucleus in sporadic amyotrophic lateral sclerosis (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 190-192 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Intermediolateral nucleus ; Quantitative examination ; Bunina body ; Neuronal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological and morphometrical observations of the intermediolateral nucleus (IML) at the levels of the upper and lower thoracic segments (T2 and T9) were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. No Bunina bodies were found in the IML neurons in either the ALS patients or the control subjects. Only a small number of spheroids were encountered rarely in the IML in both the patients and controls. The number of neurons in the IML in the non-respirator-supported ALS patients were reduced at T2, but well preserved at T9 compared with the control subjects. In the respirator-supported ALS patients, there was a marked reduction of IML neurons at both T2 and T9. Considering the absence of direct synaptic contacts with anterior horn cells, these neurons, without the formation of Bunina bodies, appeared to be involved primarily in the disease process in sporadic ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334889
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5 (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 626-631 
    Details
    ISSN: 1432-0533
    Keywords: C-series gangliosides ; Microtubule-associated protein 5 ; Fetal antigen ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistological study of Alzheimer's brains was performed using antibodies to C-series gangliosides and microtubule-associated protein 5 (MAP5), and their staining patterns were compared with those of antibodies to tau and β-amyloid precursor protein. Antibodies to C-series gangliosides and MAP5, both of which are known to preferentially expressed in the fetal brains, immunostained dystrophic neurites of senile plaques, neurofibrillary tangles and neuropil threads abundant in 3rd and 5th layers in the cerebral cortex, all of which are considered to be pathological hallmarks of Alzheimer's disease. The immunostaining patterns of these structures by antibodies to C-series gangliosides and MAP5 were similar to those by the antibody to tau. These three antibodies also immunostained some neurons in Alzheimer's brain, although their staining patterns were slightly different from one another; i.e., both diffuse and granular patterns were seen by the antibody to tau, but only granular pattern by the antibodies to C-series gangliosides and MAP5. These neurons immunostained by these three types of antibodies appeared to be the precursors of the classical neurofibrillary tangles, as positively stained neurons were not seen in the brains of non-demented cases. The presence of fetal antigens such as the C-series gangliosides and MAP5 in Alzheimer's brain may suggest that regeneration or sprouting of neurons is ongoing in association with the re-induction of gene expression characteristic for the brain in the early stage of development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296372
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  • 9
    Electronic Resource
    Electronic Resource
    Primary leptomeningeal glioma: ultrastructural and laminin immunohistochemical studies (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 538-542 
    Details
    ISSN: 1432-0533
    Keywords: Primary leptomeningeal glioma ; Ultrastructure ; Basal lamina ; Laminin ; Heterotopic glial tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied a case of primary leptomeningeal glioma (PLG) on the left parietal lobe of a 74-year-old woman and compared the tissue with heterotopic glial tissue from another case. The PLG tumor consisted of spindle-shaped cells with marked nuclear atypism, which tended to be arranged in a fascicular pattern, and the majority of its cells were positive for glial fibrillary acidic protein. Ultrastructural examination demonstrated that most of the tumor cells contained intermediate filaments and often junctional complexes were present on their plasma membranes. Frequently, basal lamina-like structures surrounding the tumor, cell surfaces were observed. Laminin immunohistochemistry clearly demonstrated a fine network of linear positive staining around the cytoplasm and processes of the tumor cells. The ultrastructure of the heterotopic glial tissue consisted of many astrocytes partially surrounded by basal lamina. These findings strongly suggest that PLG is a distinct tumor, which arises from the heterotopic astrocytes within the subarachnoid space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310033
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  • 10
    Electronic Resource
    Electronic Resource
    Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 581-583 
    Details
    ISSN: 1432-0533
    Keywords: Parkinson's disease ; Lewy body ; Enteric nervous system ; Immunohistochemistry ; Vasoactive intestinal polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We performed immunohistochemical analysis of specimens from three autopsied patients with Parkinson's disease, using antibodies to tyrosine hydroxylase (TH), vasoactive intestinal polypeptide (VIP), somatostatin, met-enkephalin, leu-enkephalin and substance P in an attempt to reveal the types of neurons that contain Lewy bodies (LBs) in the paravertebral and celiac sympathetic ganglia and in the enteric nervous system of the alimentary tract. In the sympathetic ganglia, almost all LB-containing neuronal cell bodies and processes were immunoreactive for TH. In the alimentary tract, however, most LBs were found in the VIP-immunoreactive (VIP-IR) neuronal cell bodies and processes. In spite of the significant presence of TH-IR neuronal cell bodies and processes in the alimentary tract, LB-containing TH-IR neuronal elements were rarely encountered. These findings indicate that in the alimentary tract, the VIP neuron system is mainly involved in the disease process of Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294234
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