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  • 1
    Electronic Resource
    Electronic Resource
    Chain rigidity of substituted aromatic polyamides (1991)
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 4142-4147 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00014a028
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  • 2
    Electronic Resource
    Electronic Resource
    HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects (1991)
    Springer
    Diabetologia 34 (1991), S. 133-136 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; HLA-DQA1 gene ; HLA-DQB1 gene ; tumour necrosis factor ; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study HLA-DQA1 and TNF genes in addition to HLA-DQB1 gene were investigated at DNA level for elucidation of the genetic backgrounds of Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. DNA, amplified by polymerase chain reaction, was subjected to allele specific oligonucleotide dot blot analysis, restriction fragment length polymorphism analysis or DNA sequencing. Polymorphism of the TNF gene to NcoI did not correlate with Type 1 diabetes in Japanese patients. DQw1.2 had a protective effect against the disease, the DQA1*1 allele was significantly decreased and DQA1*3 allele was significantly increased. Seventeen out of twenty-two Type 1 diabetic patients (77%) were homozygous for DQA1*3 and five out of twenty-two (23%) heterozygous. The DQA1*3 gene of Type 1 diabetic patients had a normal nucleotide sequence. Furthermore, DQA1*3 was found unexpectedly in two patients without DR4 or DR9. These data indicate that DQA1 gene confers susceptibility and resistance to Type 1 diabetes in Japanese subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500386
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of microtubule-associated protein 2 and ubiquitin in chronically aluminum-intoxicated rabbit brain (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 346-352 
    Details
    ISSN: 1432-0533
    Keywords: Aluminum ; Neurofibrillary change ; Microtubule-associated protein 2 ; Ubiquitin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental neurofibrillary change was produced in rabbit brains by daily subcutaneous aluminum tartrate injection for 40 days. The production of experimental neurofibrillary changes was confirmed by immunostaining with antibodies against neurofilament triplet proteins and the brain tissue was studied immunohistochemically with antibodies against microtubule-associated protein (MAP) 2 and ubiquitin. The hippocampal neurons of the chronically aluminum-intoxicated rabbit brain showed diminished staining of dendrites by anti-MAP2 antibody. The length of anti-MAP2-positive dendrites in hippocampus was significantly shorter than that of the control brain. In the cortex somata of a subset of pyramidal neurons were intensively stained by anti-MAP2 antibody, while the MAP2 immunoreactivity of distal dendrites was diminished. The immunostaining by anti-ubiquitin antibody revealed the positive staining of the neurons bearing experimental neurofibrillary changes in the lower brain stem nuclei. It is speculated that MAP2 dislocation and ubiquitination are accompanying phenomena of the production of experimental neurofibrillary changes in chronically aluminum-intoxicated rabbit brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296545
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  • 4
    Electronic Resource
    Electronic Resource
    Relationship between regional changes of soil physical properties and volcanic stratigraphy on the southern slope of Batur volcano in the island of Bali, Indonesia (1994)
    Springer
    Environmental geology 23 (1994), S. 182-191 
    Details
    ISSN: 1432-0495
    Keywords: Soil physical properties ; Volcanic stratigraphy ; Groundwater flow regime ; Batur volcano ; Bali ignimbrite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The present paper shows the relationship between the regional changes of soil physical properties and the volcanic stratigraphy on the southern slope of Batur volcano in the island of Bali, Indonesia, from the hydrogeological point of view based on the data obtained from field observations and laboratory experiments. The Bali soils data showed marked differences in regional distribution and their characteristics are closely correlated to the distribution of the volcanic stratigraphy derived from the Batur volcanic activities with the eruption about 23,700 years ago. On the basis of these data, the hydrogeological situation of the slope are presented schematically and groundwater flow regimes on the slope, such as recharge and discharge areas, are also classified according to the hydrogeological information. These classifications of groundwater flow regimes are useful to consider the occurrence of hydrological phenomena such as springs and paddy field distributions observed on the slope.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00771787
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  • 5
    Electronic Resource
    Electronic Resource
    An α-fetoprotein producing pancreatic cystadenocarcinoma (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 377-380 
    Details
    ISSN: 1432-1440
    Keywords: Mucinous cystadenocarcinoma ; Pancreas ; α-Fetoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An autopsy case of an 83-year-old Japanese woman with pancreatic cancer with significantly elevated serum α-fetoprotein levels is reported. The pancreatic tumor was a mucinous cystadeno-carcinoma with multiple metastasis to the liver. The immunohistochemistry for α-fetoprotein revealed positive reactivity in the cytoplasm of cancer cells in the primary and liver metastatic lesions. The current case is the first reported in which mucinous cystadenocarcinoma of the pancreas produced α-fetoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252831
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  • 6
    Electronic Resource
    Electronic Resource
    Piperonyl butoxide induces hepatocellular carcinoma in male CD-1 mice (1994)
    Springer
    Archives of toxicology 68 (1994), S. 467-469 
    Details
    ISSN: 1432-0738
    Keywords: Key words: Piperonyl butoxide – Hepatocellular carcinoma – Hemangiosarcoma – Carcinogenesis – Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Male CD-1 mice in groups of 52, 53 or 100 were administered piperonyl butoxide (α-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene) in the diet at levels of 0 (control), 0.6 and 1.2% for 12 months. Hepatocellular carcinoma was induced in treated groups in a dose-dependent manner but not in the control group. The incidences of hepatocellular carcinoma were 11.3 and 52.0% in mice given 0.6 and 1.2% piperonyl butoxide, indicating that piperonyl butoxide can cause hepatocellular carcinoma in mice as it is known to do in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050098
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  • 7
    Electronic Resource
    Electronic Resource
    Increase of urinary and serum hydroxyproline in subjects exposed to cadmium (1991)
    Springer
    Bulletin of environmental contamination and toxicology 47 (1991), S. 609-616 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700953
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  • 8
    Electronic Resource
    Electronic Resource
    Remote epileptogenic focus detected by electrocorticogram in a case of cavernous angioma (1994)
    Springer
    Acta neurochirurgica 127 (1994), S. 236-239 
    Details
    ISSN: 0942-0940
    Keywords: Cavernous angioma ; ECoG ; epileptogenic focus ; surgical treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a case of cavernous angioma, a remote gyrus, which was found to contain an epileptogenic focus by intraoperative electrocorticography (ECoG), was resected simultaneously with lesionectomy. The patient was a 27-year-old male who was referred to our hospital because of frequent systemic tonic-clonic convulsions. ECoG revealed an epileptogenic focus not only in the cortex around the angioma-affected tissue of the left frontal lobe but also in an in addition to lesionectomy. The postoperative course was uneventful. Now (two years after surgery), the patient is seizure-free In the surgical treatment of convulsions-accompanied by cavernous angioma, it is essential not only to detect epileptogenic foci by intraoperative ECoG but also to remove these foci together with the angioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808773
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  • 9
    Electronic Resource
    Electronic Resource
    Nucleolar organizer region score and Ki-67 labelling index in high-grade gliomas and metastatic brain tumours (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 37-41 
    Details
    ISSN: 0942-0940
    Keywords: Glioma ; metastatic brain tumour ; Ki-67 ; nucleolar organizer regions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen cases of malignant brain tumours comprising 6 anaplastic astrocytomas, 3 glioblastoma multiforme, 1 medulloblastoma and 6 metastatic brain tumours were investigated independently by a silver colloid method for nucleolar organizer regions (NORs) and an immunohistochemistry using a monoclonal antibody against a nuclear antigen, Ki-67, in proliferating cells. The correlation between the mean number of NORs and the percentage of Ki-67 labelled cells (Ki-67 labelling index) was examined. In addition, four normal brain tissue samples without neoplastic cells were stained for NOR. The mean number of NORs in these malignant brain tumours was significantly greater than that in normal astrocytes (p〈0.001). Moreover, both the mean number of NORs and the Ki-67 labelling index in metastatic brain tumours were significantly greater than those in high-grade gliomas (p〈0.001). The Ki-67 labelling index and the mean number of NORs in malignant brain tumours including metastatic brain tumours were found to be linearly related (r=0.86). These results suggest that the proliferative potential of malignant brain tumours could be evaluated by NOR score as well as Ki-67 labelling index and that such indices provide clear discrimination between high-grade gliomas and metastatic brain tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405695
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  • 10
    Electronic Resource
    Electronic Resource
    Folding thermodynamics and kinetics of imprinted renaturable heteropolymers (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 8246-8257 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Recently, a procedure was suggested to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an "active site'' capable of specifically recognizing a given target molecule. This procedure was originally studied using a computer simulation of the thermodynamics of lattice 27-mers. This analysis is extended to the thermodynamic study of longer chains (36-mers) and different types of short range interactions. We found, in the best conditions, a 50% success rate of creating renaturable heteropolymers, thus confirming the original results. Folding kinetics as examined by Monte Carlo simulation show that the imprinted sequences can reach the ground state reliably and quickly. Finally, we compare the correlations found in the imprinted sequences with those found in natural proteins. We interpret these results as the confirmation of the efficacy of the polymerization procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.468195
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