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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 10 (1994), S. 3550-3554 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annales geophysicae 12 (1994), S. 612-624 
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A superposed epoch analysis of geomagnetic storms has been undertaken. The storms are categorised via their intensity (as defined by the Dst index). Storms have also been classified here as either storm sudden commencements (SSCs) or storm gradual commencements (SGCs, that is all storms which did not begin with a sudden commencement). The prevailing solar wind conditions defined by the parameters solar wind speed (vsw), density (〈rho〉sw) and pressure (Psw) and the total field and the components of the interplanetary magnetic field (IMF) during the storms in each category have been investigated by a superposed epoch analysis. The southward component of the IMF, appears to be the controlling parameter for the generation of small SGCs (-100 nT〈 minimum Dst\leq-50 nT for\geq4 h), but for SSCs of the same intensity solar wind pressure is dominant. However, for large SSCs (minimum Dst\leq-100 nT for \geq4 h) the solar wind speed is the controlling parameter. It is also demonstrated that for larger storms magnetic activity is not solely driven by the accumulation of substorm activity, but substantial energy is directly input via the dayside. Furthermore, there is evidence that SSCs are caused by the passage of a coronal mass ejection, whereas SGCs result from the passage of a high speed/ slow speed coronal stream interface. Storms are also grouped by the sign of Bz during the first hour epoch after the onset. The sign of Bz at t=+1 h is the dominant sign of the Bz for \sim24 h before the onset. The total energy released during storms for which Bz was initially positive is, however, of the same order as for storms where Bz was initially negative.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We report on the response of high-latitude ionospheric convection during the magnetic storm of March 20–21 1990. IMP-8 measurements of solar wind plasma and interplanetary magnetic field (IMF), ionospheric convection flow measurements from the Wick and Goose Bay coherent radars, EISCAT, Millstone Hill and Sondrestrom incoherent radars and three digisondes at Millstone Hill, Goose Bay and Qaanaaq are presented. Two intervals of particular interest have been identified. The first starts with a storm sudden commencement at 2243 UT on March 20 and includes the ionospheric activity in the following 7 h. The response time of the ionospheric convection to the southward turning of the IMF in the dusk to midnight local times is found to be approximately half that measured in a similar study at comparable local times during more normal solar wind conditions. Furthermore, this response time is the same as those previously measured on the dayside. An investigation of the expansion of the polar cap during a substorm growth phase based on Faraday’s law suggests that the expansion of the polar cap was nonuniform. A subsequent reconfiguration of the nightside convection pattern was also observed, although it was not possible to distinguish between effects due to possible changes in By and effects due to substorm activity. The second interval, 1200–2100 UT 21 March 1990, included a southward turning of the IMF which resulted in the Bz component becoming -10 nT. The response time on the dayside to this change in the IMF at the magnetopause was approximately 15 min to 30 min which is a factor of \sim2 greater than those previously measured at higher latitudes. A movement of the nightside flow reversal, possibly driven by current systems associated with the substorm expansion phases, was observed, implying that the nightside convection pattern can be dominated by substorm activity.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1106
    Keywords: MPTP ; Graft ; Behavior ; Parkinson's disease ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fetal substantia nigra (SN) cells were transplanted into the caudate nucleus (CN) of four vervet monkeys (Cercopithecus aethiops sabaeus) that had been treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP treatment appears to produce a syndrome similar to that observed in patients with idiopathic Parkinson's disease. Normal and parkinsonian behaviors were quantitated by trained observers 5 days/week. Twenty-eight behaviors based on previous factor analyses were individually scored and rated. Parkinsonian signs included freezing, head and limb tremor, difficulty in eating, delayed initiation of movement, poverty of movement, tremor that stopped with intention, decreased response to threats, and lying immobile in the cage. These signs were combined to give an overall rating of parkinsonism. A summary measure of ‘normal’ healthy behavior was also examined, including such behaviors as yawning, scratching, self-grooming, shifting, and eating. Overall ratings of parkinsonism increased and those of healthy behavior decreased after MPTP. In the 4 monkeys grafted with fetal SN cells into the CN, behavior returned to pre-treatment levels by the time of sacrifice (2, 5, or 7.5 months after grafting). Three control subjects were transplanted with either SN cells into an inappropriate brain site (cortex) or inappropriate, non-dopaminergic, cells (cerebellar) into the CN. Subjects were also compared with three control animals that did not receive MPTP but received cryopreserved or fresh SN and other cells into the CN. Only MPTP-treated subjects that received SN cells into the CN showed evidence of a reversal of the MPTP syndrome after transplantation. In addition, grafting in animals that were not MPTP-treated did not appear to affect behavior. This paper reports the specific behavioral effects of severe MPTP toxicity that were or were not reversed after transplantation and suggests that only fetal SN cells grafted into the CN may be able to reverse behavioral deficits in MPTP-treated monkeys.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 33 (1991), S. 38-42 
    ISSN: 1432-1920
    Keywords: Facet joints ; Lumbar spine ; Joint inclusions ; Fat pads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The polar recesses, superior and inferior to lumbar facet joints, are filled by fat pads from which fatfilled synovial folds project between the articular surfaces for a distance of two to four millimetres. The intracapsular superior recess lies between the ligamentum flavum and the lamina above. The extracapsular inferior recess lies on the back of the lamina below and communicates with the joint through a hole in the inferior capsule. The intracapsular folds move freely in and out of the joint during movements. These features are demonstrated in anatomic studies using transverse sections and radiologic studies using computed tomography. In about 4% of lumbar spines examined, the intraarticular fat pads are enlarged and extend from the joint recess(es) into the middle third of one or more facet joints. The fat pads can be identified in CT scans by their radiolucency and distinguished from vacuum phenomenon by measuring their attenuation values. The cause of the intra-articular enlargement of the fat pads is unknown, but it is suggested that their extension into the middle third of the joint may be secondary to degenerative change in the motion segment with capsular laxity in the affected joint.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Yohimbine ; Morphine ; Naloxone ; Withdrawal ; Tail flick latency ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Noradrenergic neuronal hyperactivity following chronic morphine administration has been postulated to cause withdrawal signs and symptoms. Suppression of this hyperactivity, for example, by clonidine attenuates withdrawal. It might follow, therefore, that the prevention of suppression of noradrenergic systems during chronic morphine administration might diminish hyperactivity and prevent withdrawal. If the normalization of noradrenergic activity during opioid administration did not also suppress analgesia, it might be of medical and theoretical interest. To test this hypothesis, we gave the alpha-2-antagonist yohimbine to rats in order to increase noradrenergic activity during morphine treatment and then subsequently precipitated morphine withdrawal with naloxone. Six groups were examined: saline controls (N=11), morphine (N=11), morphine + 2.0 mg/kg/day yohimbine (N=15), morphine + 3.0 mg/kg/day yohimbine (N=5), 2.0 mg/kg/day yohimbine (N=11) and 3.0 mg/kg/day yohimbine (N=5). Subjects received 75 mg morphine pellets implanted on day 1,4 and 6 of the treatment or sham implantation. Yohimbine was delivered throughout the morphine treatment by subcutaneously implanted osmotic pumps. On day 7, all subjects were given 1.0 mg/kg naloxone and rated for behavioral signs of withdrawal. Analgesia was measured by observing tail flick latencies (TFL) before and after chronic drug treatments. Naloxone-precipitated withdrawal was characterized by irritability, ptosis, penile erection, diarrhea, rhinorrhea, abnormal posture, wetdog shakes, jumping, and teeth chattering, none of which were observed in groups receiving only saline or yohimbine. Withdrawal behavior was attenuated in a dose-dependent manner when yohimbine was administered during morphine treatment but analgesia was not attenuated. It appears that yohimbine-induced antagonism of alpha-2-adrenergic receptors diminishes the development of the potential for adrenergic hyperactivity and morphine withdrawal without reducing opioid analgesia.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2072
    Keywords: Conditioned reinforcement ; Dopamine ; Noradrenaline ; d-Amphetamine ; Dorsal noradrenergic bundle ; Nucleus accumbens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three experiments examined the behavioural, pharmacological and neural specificity of the previously reported potentiation of responding with conditioned reinforcement following intra-accumbensd-amphetamine, by studying the effects of intraaccumbens dopamine (DA) and noradrenaline, using an acquisition of a new response procedure. In experiment 1, the effects of intra-cerebral DA infusions (5, 20, 50 µg/2 µl) were compared in four conditions: (i) intra-accumbens DA following positive pairing of the conditioned stimulus (CS) and water during training; (ii) as (i) but also following a systemic dose of the DA receptor antagonist alpha-flupenthixol; (iii) intra-accumbens DA following random pairing of the CS and water during training; and (iv) as (i) but with intra-caudate rather than intra-accumbens DA. The results showed that only with intra-accumbens DA in the positive pairing condition was there a significant dose-dependent increase in responding. In experiment 2, the effects of a higher range of doses (20, 100, 200 µg) and smaller infusion volume (5, 25, 50 µg/l µl) of intra-accumbens DA were studied, in comparison with a similar range of doses (5, 25, 50 µg/l µl) of intra-accumbens noradrenaline (NA). Only DA produced a selective, dose-dependent increase in responding with conditioned reinforcement. In experiment 3 neurotoxic lesions of the dorsal noradrenergic bundle (DNAB) using 6-hydroxydopamine producing profound (about 90%) depletion of cortical and nucleus accumbens NA levels had no effect on the increased responding with conditioned reinforcement produced by intra-accumbensd-amphetamine (3, 10, 30 µg/l µl). The results are discussed in terms of the neurochemical mediation of the potentiation of the effects of conditioned reinforcers byd-amphetamine and the role of DA-dependent mechanisms of the nucleus accumbens in reward-related processes.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1572-8889
    Keywords: Reduviidae ; intraspecific interactions ; cannibalism ; predation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The behaviors exhibited by first-instarSinea diadema (F.) (Hemiptera: Reduviidae) during intraspecific interactions are described. Five distinct behaviors were characterized: posturing, striking, stalking, stridulating, and beaking. Distinct bouts of grappling were also noted. Interactions between unfed 2-day-old nymphs, unfed 3-day-old nymphs, and unfed 5-day-old nymphs were recorded and analyzed. The behavior of the nymphs changed with the duration of food deprivation. As the period of food deprivation increased from 2 to 5 days, the frequency of posturing decreased as the frequency of beaking increased. During noncannibalistic interactions, posturing or striking by one nymph was most frequently followed by posturing by the other nymph. In contrast, during cannibalistic interactions, posturing or striking was usually followed by beaking. The incidence of grappling increased with the duration of food deprivation. Moreover, grappling always preceded cannibalism. Although first instars were capable of capturing and killing conspecifics of the same age, cannibalism occurred only after 4 days of food deprivation. These results suggest that a decision-making process is involved. During interactions the nymphs can assess the vulnerability of the opponent. Whereas recently emerged nymphs usually forego the risk of attacking conspecifics, the attacks made by nymphs deprived of food are more persistent despite the danger of predation by their opponent.
    Type of Medium: Electronic Resource
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