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  • 1
    Electronic Resource
    Electronic Resource
    Abnormal results of biochemical liver function tests in breast-fed infants with prolonged indirect hyperbilirubinaemia (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 310-313 
    Details
    ISSN: 1432-1076
    Keywords: Breast milk jaundice ; Liver dysfunction ; Cholestasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To clarify the relationship between hyperbilirubinaemia and abnormal results of biochemical liver function tests in infants with breast milk jaundice (BMJ), 58 breast-fed infants with indirect hyperbilirubinaemia were enrolled in this study. Sera obtained from the above infants were subjected to routine liver function tests. Although serum transaminases were within normal limits in all 58 patients, serum alkaline phosphatase levels were abnormally increased in 13, gamma-glutamyltranspeptidase in 8 and total bile acids in 11 out of all patients examined. A total of 18 (31%) patients had abnormal results in at least one item of the liver function tests. The intrinsic bile acid loading test showed postprandial increases in bile acids in 5 of 16 (31%) patients examined at either 60 or 120 min, while all 13 breast-fed, agematched controls had no abnormal results. The decrease in rate of serum bilirubin levels after the 3-day discontinuation of breast-feeding was significantly less in patients with increased fasting bile acids than in patients with normal fasting levels of serum bile acids. These results may suggest that mild hepatic dysfunction or cholestasis is associated with indirect hyperbilirubinaemia in some infants with BMJ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955928
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  • 2
    Electronic Resource
    Electronic Resource
    Chronic pancreatitis in a child with glycogen storage disease type 1 (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 852-853 
    Details
    ISSN: 1432-1076
    Keywords: Glycogen storage disease ; Pancreatitis ; Endoscopic retrograde cholangiopancreatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of chronic pancreatitis in an 8-year-old boy with glycogen storage disease type 1a (GSD 1a) is presented. This patient had a history of hyperlipidaemia unresponsive to dietary therapy, e.g., a carbohydraterich diet, uncooked cornstarch, and nocturnal intragastric tube feedings. He had recently suffered bouts of abdominal pain and diarrhoea. Serum amylase and trypsin were elevated, abdominal CT revealed the presence of a pseudocyst of the pancreas. The presence of chronic pancreatitis was confirmed by endoscopic retrograde cholangiopancreatography and an infected pseudocyst was removed at laparotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955007
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The X-gene of human hepatitis B virus transactivates the c-jun and α-fetoprotein genes (1994)
    Springer
    Archives of virology 134 (1994), S. 369-378 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The X-gene product of human hepatitis B virus is a transacting transcriptional factor which activates a variety of heterologous viral and host promoters/enhancers. We have found that the X-gene product can significantly transactivate the regulatory sequences located at the 5′-upstream of the c-jun oncogene when a reporter plasmid containing the sequences was co-transfected to HepG2 cells with an X-gene expression plasmid. The results of mutational analysis indicate that the X-gene activation requires the AP-1 sequence of the c-jun gene. Furthermore, we also found that the X-gene is capable of activating the 5′-upstream sequence of the α-fetoprotein gene. There are at least two elements that respond to the X-gene transactivation. One is located in the sequences between −5100 and −2900, and the other is at the C/EBP site. Therefore, the X-gene activates the c-jun and α-fetoprotein genes through different host factors, namely AP-1 and C/EBP, respectively. The results of c-jun activation by the X-gene strongly support the previous hypothesis that the X-gene may play a critical role in the development of hepatocellular carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310574
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  • 4
    Electronic Resource
    Electronic Resource
    Mutational analysis of enhancer domains responsive to trans-activation by the X gene of human hepatitis B virus (1990)
    Springer
    Archives of virology 114 (1990), S. 237-242 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The X gene product of human hepatitis B virus (HBV) trans-activates the HBV enhancer. In order to identify domains responsive to trans-activation by the X gene, we introduced a series of mutations into the HBV enhancer and assayed the enhancer activities in the presence of the X gene product. Our results suggest that the EP domain of the enhancer is essential for trans-activation by the X gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310752
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    Paper (German National Licenses)
    Fulltext
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