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  • 1
    Electronic Resource
    Electronic Resource
    Total solid-phase synthesis and prolactin-inhibiting activity of the gonadotropin-releasing hormone precursor protein and the gonadotropin-releasing hormone associated peptide (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 8799-8809 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00152a016
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Formation of field discontinuities and islands in visual cortical maps (1994)
    Springer
    Biological cybernetics 70 (1994), S. 525-531 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract. The representations of visual hemifields in the extrastriate areas of various species exhibit field discontinuities and islands. We propose that these violations of retinotopy are a developmental consequence of the elongated shape of the respective cortical areas. To substantiate this claim, we investigated a model of activity-driven map formation. In agreement with observations, this model yields maps with field discontinuities if the cortical areas exceed a threshold elongation. Moreove r, within the same model island representations in the periphery and the area centralis can also be understood. A multistability of the solutions in the model gives a very simple explanation for the observed interindividual variability of maps in cats. The model leads to a prediction of the radial dependence of the areal magnification factor near field discontinuities, which could be accessible for a high precision mapping experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004220050055
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Formation of field discontinuities and islands in visual cortical maps (1994)
    Springer
    Biological cybernetics 70 (1994), S. 525-531 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The representations of visual hemifields in the extrastriate areas of various species exhibit field discontinuities and islands. We propose that these violations of retinotopy are a developmental consequence of the elongated shape of the respective cortical areas. To substantiate this claim, we investigated a model of activity-driven map formation. In agreement with observations, this model yields maps with field discontinuities if the cortical areas exceed a threshold elongation. Moreover, within the same model island representations in the periphery and the area centralis can also be understood. A multistability of the solutions in the model gives a very simple explanation for the observed interindividual variability of maps in cats. The model leads to a prediction of the radial dependence of the areal magnification factor near field discontinuities, which could be accessible for a high precision mapping experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198805
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of bead diameter on the accuracy of two current techniques used to quantify bone ingrowth in porous-coated implants (1994)
    Springer
    Journal of materials science 5 (1994), S. 29-32 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The effect of the bead diameter on the accuracy of two techniques used in bone ingrowth quantification, microradiography and backscattered electron imaging-scanning electron microscopy (BEI-SEM), was assessed using porous-coated implants. Two groups of seven titanium porous implants (group A: bead size 250–350 μm and group B: 500–700 μm) were implanted for 12 weeks in a canine model. After euthanasia, the same histological slides were prepared for microradiography and BEI-SEM. The percentage of bone, bone ingrowth, bone ongrowth, porosity and bone index were determined by a point counting method using images from both techniques. ANOVA and Tukey's test were used to compare the results from the different bead sizes and techniques. The results showed significant higher bone ingrowth in microradiography groups, and significant lower porosity in only the fine-bead microradiography group (group A size). Microradiography also obtained significantly higher bone ongrowth, but only for the coarse bead size group (group B). From these results it was concluded that microradiography decreases the porosity of the porous coating compared with BEI-SEM. This effect seems to be dependent on the bead diameter. The smaller the diameter, the greater the effect. Furthermore, microradiography increases bone ingrowth which seems to be affected independently of the bead diameter, becoming the most sensitive parameter to increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121150
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  • 5
    Electronic Resource
    Electronic Resource
    Bone ingrowth analysis and interface evaluation of hydroxyapatite coated versus uncoated titanium porous bone implants (1994)
    Springer
    Journal of materials science 5 (1994), S. 411-416 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Fourteen titanium porous-coated implants with a cylindrical shape (length 22 mm and diameter 5±0.3 mm) were prepared. Bead size was 250–350 μm. Seven implants were plasma-sprayed with hydroxyapatite and the other seven remained uncoated. Implants, both hydroxyapatite-coated and uncoated, were randomly selected and press fitted longitudinally into the proximal femoral cancellous bone bilaterally in seven dogs. After 12 weeks the dogs were euthanized and push-out and histomorphometric backscattered electron microscopy studies were carried out. No statistical differences in the mechanical tests were observed. Comparing hydroxyapatite-coated versus uncoated implants, the histomorphometric results showed statistical significance in the percentage of bone (p=0.01); and in bone index, ratio between bone ingrowth and bone ongrowth (p=0.01). The size of the bone implant interface was smaller in the hydroxyapatite applied to spherical bead titanium porous coatings were demonstrated. These morphological and histomorphometric results support the concepts involved with the use of hydroxyapatite as a coating for uncemented porous prosthetic devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00058975
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  • 6
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 156-159 
    Details
    ISSN: 1619-7089
    Keywords: Immunoscintigraphy ; Technetium 99m-labelled antibodies ; CD4-specific (T-lymphocyte) antibodies ; Rheumatoid arthritis ; Localisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200–300 μg of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes of one patient were isolated on a Ficoll-Hypaque gradient and labelled with the antibody in vitro. Scans were performed 1.5 h, 4 and 24 h post injection in anterior and posterior views. In all patients, diseased joints could be clearly imaged at as early as 1.5 h. The localisation of the diseased joints correlated (P〈0.01) with the clinical signs, with the early methylene diphosphonate (MDP) scan (P 〉 0.01) and only weakly with the late bone scan (P 〉 0.05). According to these data we conclude that99mTc-labelled CD4-specific antibodies specifically image actively diseased joints in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811445
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Bone scan and red blood cell scan in a patient with epidermal naevus syndrome (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 369-371 
    Details
    ISSN: 1619-7089
    Keywords: Bone scan ; Red blood cell scan ; Epidermal naevus syndrome ; Haemangiomas of bone ; Hypophosphataemic osteomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A bone scan and red blood cell scan in the rare epidermal naevus syndrome, associated with multiple haemangiomas of the bone and hypophosphataemic osteomalacia in a 20-year-old man are reported. The typical pattern of osteomalacia on the bone scan was associated with lesions of increased bone metabolism in the peripheral bones. The haemangiomas did not pool labelled red blood cells. Thus, the bone scan seems to be suitable for diagnosing the complete extent of haemangiomas in bone, but they could not be specifically proven by red blood cell pooling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01268029
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 924-927 
    Details
    ISSN: 1619-7089
    Keywords: Iodine-123-Tyr-Octreotide ; Somatostatin receptors ; In vivo ; In vitro ; Pancreatic islet cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tyr-3-Octreotide is a synthetic derivative of somatostatin and a somatostatin-receptor analogue. The iodine-123-labelled compound localizes somatostatin-receptor-positive tumours. In this paper two patients are reported in whom somatostatin receptors were demonstrated in vitro. In a 60-year-old female with an islet cell carcinoma of the pancreas, multiple liver metastases and previously unrecognized bone metastases in the right acetabulum could be diagnosed as the reason for a persistent hypoglycaemia. In a 60-year-old male an islet cell carcinoma of the pancreas was localized with123I-Tyr-3-octreotide. The somatostatin receptors were demonstrated in vitro and the tumour was successfully treated with somatostatin. These studies demonstrate that123I-Tyr-3-octreotide offers the possibility of localizing somatostatin-receptor-positive tumours and their metastases. Moreover the method makes it possible to determine the receptor status of a tumour in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258458
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 176-180 
    Details
    ISSN: 1619-7089
    Keywords: Anti-CD4 monoclonal antibody ; Anti-carcinoembryonic antigen monoclonal antibody ; Immunoscintigraphy ; Technetium-99m labelling ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175768
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  • 10
    Electronic Resource
    Electronic Resource
    Humane Anti-Mausimmunglobulin-Antikörper als Störfaktoren der TSH-Bestimmung (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 220-223 
    Details
    ISSN: 1432-1440
    Keywords: Human Anti-Mouse-Antibodies ; TSH-IRMA ; Monoclonal antibody therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monoclonal murine antibodies are increasingly used for immunotherapy and in vivo diagnostic procedures such as immunoscintigraphy. The therapeutic or diagnostic reagent however, is a foreign antigen, which may induce host reactivity. This may interfere with the therapeutic or diagnostic reagent in vivo, resulting in a loss of efficacy or the necessity to increase dosages. In addition, there is an important interference to in vitro immunoassays detecting specific antigens utilizing murine monoclonal antibodies. In the present study, sera of patients who had undergone a therapeutic trial using 140 mg of an anti-CD4 antibody, were investigated. Human anti-murine-immunoglobulin-antibodies (HAMA) were detected 2–3 weeks after treatment was started and reached maximal amounts of 0.8 μg/ml after a single and 2 μg/ml after a repeated treatment course. Parallely raised values of TSH were found in sera containing HAMAs of more than 0.3 μg/ml. Elevations of TSH levels up to 13 μU/ml were most pronounced after a repeated trial of the murine antibody and were detectable up to 20 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646945
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