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  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 16 (1994), S. 221-228 
    ISSN: 1279-8517
    Keywords: Stomach ; Venous drainage ; Gastric esophagoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Ce travail a été effectué dans le but de préciser l'architecture générale du système veineux de l'estomac et son mode de drainage dans des conditions normales. Il est aussi motivé par la recherche du rôle du drainage veineux dans la genèse des désunions, des fistules anastomotiques, des sténoses après oesophagoplastie tubulée pédiculisée sur les vaisseaux gastro-épiploïques droits. 60 estomacs prélevés sur des cadavres frais ont été étudiés par la méthode d'injection-corrosion. Le produit utilisé est l'Altufix P10 coloré. 35 pièces ont été injectées globalement par la veine mésentérique supérieure, 15 pièces par la même voie mais après clampage de la veine splénique, de la veine gastrique gauche et de la veine gastrique droite, ce qui correspond a la technique de gastrolyse effectuée pour oesophagoplastie, et 10 ont été injectées simultanément par les produits colorés en quatre couleurs par les veines gastrique gauche, gastrique droite, mésentérique supérieure et splénique (ou liénale) pour préciser leur territories correspondants. L'origine, le trajet, la terminaison, le territoire et le calibre des principales veines de l'estomac ont été étudiés. L'analyse des résultats permet de confirmer la richesse des anastomoses veineuses de l'estomac qui s'effectuent d'une part, entre deux arcades extrapariétales au niveau de la grande et de la petite courbure, et d'autre part au niveau de communications intrapariétales disposées perpendiculairement à ces deux arcades. Il apparaît que la veine gastro-épiploïque droite ne peut pas toujours assurer le drainage de la totalité de l'estomac. Les facteurs influençants sont discutés. Le risque de stase veineuse dans l'oesophagoplastie gastrique doit toujours être pris en compte.
    Notes: Summary This study was made with the aim of specifying the general architecture of the venous system of the stomach and its mode of drainage under normal conditions, and also of investigating the role of the venous drainage in the origin of disunion, anastomotic fistula and structure after tubular esophagoplasty pedicled on the right gastroepiploic vessels. Sixty stomachs removed from fresh cadavers were studied by injection-corrosion, using colored Altufix P10 as the injection mass. 35 specimens were injected globally via the superior mesenteric v., 15 by the same route but after clamping of the splenic, left gastric and right gastric vv., which corresponds to the technique of gastrolysis performed in esophagoplasty, and 10 were injected simultaneously with media of four different colors via the left gastric, right gastric, superior mesenteric and splenic vv. to define their respective territories. Also studied were the origin, course, termination, territory and caliber of the main gastric veins. Analysis of the results confirmed the richness of the venous anastomoses of the stomach, effected on the one hand between the two extraparietal arches at the greater and lesser curvatures, and on the other by intraperitoneal communications arranged perpendicular to these two arches. It emerges that the right gastroepiploic v. cannot always ensure drainage of the entire stomach. The factors involved are discussed. The risk of venous stasis in gastric esophagoplasty must always be borne in mind.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 15 (1993), S. 105-111 
    ISSN: 1279-8517
    Keywords: Hepatic artery ; Cystic artery ; Ductus choledocus ; Main biliary tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Ce travail a pour but d'établir une schématisation de la distribution artérielle de la voie biliaire principale supra-duodénale, afin d'en tirer des conséquences pratiques en chirurgie biliaire, notamment lors des anastomoses bilio-digestives, biliobiliaires et des transplantations hépatiques. Il repose sur l'étude de soixante sujets frais et a été effectué selon quatre protocoles différents : dissection après injection de latex coloré, dans l'artère mésentérique supérieure (10 sujets) radiographies et dissections après injection de micropaque dans le tronc coeliaque (10) dissections après injection d'encre de chine dans l'artère hépatique commune (10), radiographies et dissections après injections sélective dans l'artère hépatique droite ou l'artère gastroduodénale (30). L'analyse des résultats permet de définir trois types de vascularisation et deux territoires, supérieur et inférieur, se chevauchant au niveau de l'abouchement du canal cystique. Les applications pratiques en chirurgie biliaire et lors des transplantations hépatiques sont discutées.
    Notes: Summary The aim of this study was to establish a plan of the arterial distribution to the main supraduodenal biliary tract in order to draw practical conclusions for biliary surgery, especially in bilio-alimentary and biliobiliary anastomoses and liver transplantation. It was based on a study of 60 fresh subjects and was carried out using four different methods: dissection after injection of colored latex into the superior mesenteric a. (10 subjects), radiography and dissection after injection of Micropaque into the celiac trunk (10), dissection after injection of Indian ink into the common hepatic a. (10) and radiography and dissection after selective injection of the right hepatic a. or the gastroduodenal a. (30). Analysis of the results leads to definition of three types of vascularisation and two territories, superior and inferior, overlapping at the level of the mouth of the cystic duct. The practical implications for biliary surgery and liver transplantation are discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 16 (1994), S. 413-418 
    ISSN: 1279-8517
    Keywords: Gastrocolic venous trunk ; Superior mesenteric vein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le mode de constitution, les mensurations et la fréquence du tronc veineux gastro-colique ont été étudiés par la technique d'injection-corrosion sur une série de 54 pièces anatomiques et par l'analyse de 50 examens TDM chez des patients indemnes de pathologie hépatique ou pancréatique. Le tronc gastrocolique a été retrouvé 51 fois sur 54 pièces anatomiques et 27 fois sur 50 examens TDM. Sa grande variabilité de constitution, de bipode, à tripode ou quadripode a été notée. Avec un diamètre moyen de 4,9 mm, il débouche sur les faces antérieure, droite ou antéro-gauche de la veine mésentérique supérieure à une distance moyenne de 15 mm au dessous du bord inférieur du confluent spléno-mésentérique. L'intérêt de la tomodensitométrie dans le bilan préopératoire d'une intervention pour hypertension portale ou tumeur du pancréas, ou dans le diagnostic d'une thrombose splénique, est mis en exergue.
    Notes: Summary The mode of formation, measurements and frequency of occurrence of the gastrocolic venous trunk were studied by the injection-corrosion technique in a series of 54 anatomic specimens and by the analysis of 50 CT studies in patients without hepatic or pancreatic disease. The gastrocolic trunk was found in 51 of the 54 anatomic specimens and in 27 of the 50 CT studies. The great variability in its formation, whether bipodal, tripodal or quadripodal, was noted. With a mean diameter of 4.9 mm, it opened into the anterior, right or antero-left aspects of the superior mesenteric v. at a mean distance of 15 mm below the inferior border of the spleno-mesenteric confluence. The value of preliminary CT assessment before an operation for portal hypertension or a pancreatic tumor or in the diagnosis of a splenic thrombosis is emphasised.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Marine biology 119 (1994), S. 597-603 
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In order to acquire more in-depth information on the site(s) of hemopoiesis in marine animals, we successfully cultured pharyngeal explants of the tunicate Styela clava over a period of 82 d. Transmission electron microscopy of resident hemocytes within explants revealed changes in hemocyte composition. Hemoblast-like cells increased shortly after commencement of the cultures (8.1% at Day 0 increasing to a maximum of 28.7% at Day 7). Autoradiography using 3H-thymidine incorporation confirmed that hemocyte proliferation in pharyngeal explants still continued after 37 d culture. During culture, the migration of many free cells into the medium resulted in sparse, residential hemocytes in the pharyngeal explants. Hemocyte migration increased by up to 4.3x105 cells/explant (max.) at 17 to 24 d, but finally decreased to 4.9x104 cells/explant at 75 to 82 d. Vital neutral-red staining revealed that many emerging cells were not hemocytes such as those found in the normal hemolymph. The continued development of in vitro approaches will strengthen analyses of immune-defense responses in tunicates which, as protochordates, are the immediate invertebrate ancestors of vertebrates.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 139 (1994), S. 15-29 
    ISSN: 1432-1424
    Keywords: Membrane ; Protein ; Folding ; Antibodies ; Channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Of the gap junction proteins characterized to date, Cx26 is unique in that it is usually expressed in conjunction with other members of the family, typically Cx32 (liver [Nicholson et al., Nature 329:732–734, 1987], pancreas, kidney, and stomach [J.-T. Zhang, B.J. Nicholson, J. Cell Biol. 109:3391–3410, 1989]), or Cx43 (leptomeninges [D.C. Spray et al., Brain Res. 568:1–14, 1991] and pineal gland [J.C. Sáez et al., Brain Res. 568:265–275,1991]). We have used specific antisera both to investigate the distribution of Cx32 and Cx26 in isolated liver gap junctions, and empirically establish the topological model of Cx26 suggested by its sequence and analogy to other connexins. Antipeptide antisera were prepared to four of the five hydrophilic domains which flank the four putative transmembrane spanning regions of Cx26. Antibodies to N-terminal residues 1–17 (αCx26-N), to residues 101–119 in the putative cytoplasmic loop (αCx26-CL), and to C-terminal residues 210–226 (αCx26-C) were all specific for Cx26. An antibody to residues 166–185 between hydrophobic domains 3 and 4 of Cx32 had affinity for both Cx26 and Cx32 (αCx32/26-E2). The antigenic sites Cx26-N, -CL and -C were each demonstrated to be cytoplasmically disposed, although the latter was conformationally hidden prior to partial proteolysis. The antigenic site for αCx32/26-E2 was only accessible after exposure of the extracellular face by separation of the junctional membranes in 8 m urea, pH 12.3. This treatment also served to reveal the region between residues 45 and 66 to Asp-N protease. The topology thus demonstrated for Cx26 is consistent with that deduced for other connexins (i.e., Cx32 and Cx43). Comparison of immunogold decorated gap junctions reacted with antibodies specific to Cx26 (αCx26-N and -CL), or to Cx32 [αCx32-CL], indicates that these connexins do not aggregate in subdomains within a junction, at least within the resolution provided by the labeling density (one antibody per 15–22 connexons). Although the presence of both connexins within a single channel could not be distinguished, possible interactions between channels is discussed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0738
    Keywords: Cisplatin ; Rat renal cortical slices ; Oxidative stress ; Cytotoxicity ; Procaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Incubation of rat renal cortical slices with 2 mM cisplatin (CDDP) at 37
    Type of Medium: Electronic Resource
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