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Abnormal hemoglobins in the Silk Road region of China (1990)

Li, Hou-jun ; Zhao, Xian-ning ; Qin, Fan ; [et al.]

Springer

Human genetics 〈Berlin〉 86 (1990), S. 231-235

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ISSN: 1432-1203

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary A review is presented of the occurrence of 24 abnormal hemoglobins (13 α-chain variants and 11 β-chain variants) in populations in the Silk Road area of Northwestern China. Most frequently occurring were Hb D-Punjab [β21(GH4)Glu→Gln] in Uygurs, Kazaks, and Khalkhas, Hb G-Taipei [β22(B4)Glu→Gly] in persons of the Han nationality, and Hb G-Coushatta [β22 (B4)Glu→Ala] in the Uygurs, Kazaks, Hans, and related nationalities. The data suggest that these variants likely originated in Central Asia, in the Han nationality of China, and in the minorities of northern China, respectively. Other variants occurred at considerably lower frequencies and were imported from other countries or arose as independent mutations. Two variants [Hb Tashikuergan or α19(AB1)Ala→Glu; Hb Tianshui or β39(C5) Gln→Arg] were observed for the first time. The data from this study of the many variants support the movements of various populations in this area, as reported in numerous historical documents.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00197711

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Effect of burn injury on corticosteroid-binding globulin levels in plasma and wound fluid (1993)

Garrel, Dominique R. ; Zhang, Limin ; Zhao, Xian-F. ; [et al.]

Oxford, UK : Blackwell Science

Wound repair and regeneration 1 (1993), S. 0

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ISSN: 1524-475X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Corticosteroids exert inhibitory effects on wound healing. They circulate, largely bound to corticosteroid-binding globulin, and the plasma concentrations of this protein determine their bioavailability. The amount of corticosteroid-binding globulin in wounds and the related effects of burn injury are not known. We have therefore measured corticosteroid-binding globulin in serum and wound fluid obtained from subcutaneously implanted sponges, retrieved 1, 3, and 10 days after insertion in rats. The effect of burning was studied by comparing rats that had a small scald burn with sham-burned control rats. In serum, corticosteroid-binding globulin levels were lower in burned rats than in control animals: the difference was 22%, 28%, and 37% for days 1, 3, and 10, respectively (p 〈 0.05 for each comparison), and values at day 1 were lower than at days 3 and 10 in control rats (p 〈 0.05) but not in burned rats. In wound fluid, corticosteroid-binding globulin levels were lower in burned rats than in control animals: the difference was 23%, 24%, and 34% for days 1, 3, and 10, respectively (p 〈 0.01 for all comparisons), and the values were significantly higher (p 〈 0.05) at day 1 when compared with values at day 10 in both groups. We therefore conclude that a small burn injury has significant effects on levels of corticosteroid-binding globulin on serum and wound fluid corticosteroid-binding globulin. The decreased concentration of wound fluid corticosteroid-binding globulin at day 10 versus day 1, with a concomitant increase in serum corticosteroid-binding globulin, suggests an accelerated degradation of the protein within the wound; this phenomenon is exaggerated by the burn injury. This is supported by Western blot analysis, which revealed the appearance of a small polypeptide that reacts with an antiserum against rat corticosteroid-binding globulin in wound fluid at day 10.