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  • Articles: DFG German National Licenses  (25)
  • 1985-1989  (25)
  • 1
    Electronic Resource
    Electronic Resource
    A new simple temperature-controlled membrane oxygenator for the perfusion of isolated rat livers (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 139-141 
    Details
    ISSN: 1420-9071
    Keywords: Membrane oxygenator ; perfusion of rat livers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new temperature-controlled membrane oxygenator for perfusing isolated rat livers was assembled using a combination of heat-exchangeable rubber tubing and silicon rubber tubing. The apparatus supplied enough oxygen to satisfy the requirements of hemoglobin-free perfused livers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02005917
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cervical dislocation of mice induces rapid accumulation of platelet serotonin in the lung (1988)
    Springer
    Inflammation research 25 (1988), S. 48-56 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As much as 3–8 μg/g wet weight of serotonin (5-hydroxytryptamine, 5HT) has been detected in mouse lung 10 sec after the animal was sacrificed by cervical dislocation. Perfusion of the lung was carried out to determine where the majority of 5HT was located. Of the total 5HT, 84.3% was measured in the perfusate in which 90–98% was recovered in the platelet-rich fraction. When lungs were dissected from mice without cervical dislocation, either after instantaneous killing by irradiation with high power microwaves or under anesthesia, 5HT in the lung was 0.40–1.60 μg/g tissue. These results show that cervical dislocation induces the entrapment of platelets in the pulmonary capillaries within 10 sec. The pulmonary accumulation of 5HT induced by cervical dislocation was approximately 50% inhibited by both prazosin and yohimbine, suggesting that the α-adrenergic receptor plays some part in the process. Norepinephrine but not isoproterenol augmented by 180% the response of pulmonary 5HT to cervical dislocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969093
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatographic assay of serum glycated albumin (1988)
    Springer
    Diabetologia 31 (1988), S. 627-631 
    Details
    ISSN: 1432-0428
    Keywords: Affinity chromatography ; anion exchange chromatography ; fructosamine ; haemoglobin A1c ; glycaemic control ; glycated protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for determination of serum glycated albumin by high-performance liquid chromatography is presented. The system involves anion exchange chromatography to separate albumin and consecutive boronate affinity chromatography to separate glycated and nonglycated albumin. The method is rapid (20 min), precise (coefficient of variation, 0.7–4.9%), requires only a small sample (5 μl), and can be automated. Assay of glycated albumin by this method is not influenced by the protein concentration of the sample or the presence of glucose. The variation in glycated albumin values in consecutive samples obtained within a day from diabetic patients (coefficient of variation, 2.02±0.65%) was significantly smaller (p〈0.001) than that of values for fructosamine (coefficient of variation, 4.33±2.0%). The values of glycated albumin in normal subjects (20.2±1.6%) were clearly less than those in diabetic patients [39,6±5.4% in 40 Type 1 (insulin-dependent) and 39.4±5.9% in 25 Type 2 (non-insulin-dependent) patients]. The serum glycated albumin level was well correlated with HbA1c in 65 diabetic patients (r=0.60). Because the life span of albumin in the circulation is short, measurement of glycated albumin should be useful as a short-term index of glycaemic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264772
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of famotidine, a new H2-receptor antagonist, in relation to renal function (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 327-331 
    Details
    ISSN: 1432-1041
    Keywords: famotidine ; renal failure ; H2-receptor antagonist ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a new, potent H2-receptor antagonist, famotidine, 20 mg i.v. was studied in 7 subjects with normal renal function and in 24 patients with varying degrees of renal impairment. The volume of distribution at steady state was 1.14 l/kg in normal subjects and was not altered in renal failure. The half-life of elimination was 2.59 h in normal subjects and was unchanged in mild renal failure (creatinine clearance, CLCR 90–60 ml/min/1.48 m2) but was increased to 4.72 h in moderate renal failure (CLCR 60–30 ml/min/1.48 m2), and to 12.07 h in severe renal failure (CLCR below 30 ml/min/1.48 m2). The cumulative urinary excretion and renal clearance of famotidine were correspondingly reduced in patients with impaired kidney function. In normal subjects and in patients with mild to moderate renal failure, about 70% of famotidine was excreted through the kidney, mainly by tubular secretion. In patients with a CLCR above 60 ml/min/1.48 m2 the normal daily dose of famotidine can be employed, but in those with a CLCR between 60 and 30 ml/min/1.48 m2 the dose should be reduced by half, and in patients with a CLCR below 30 ml/min/1.48 m2 a reduction by three quarters of the normal dose is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543332
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The second nation-wide survey in Japan of vitamin K deficiency in infancy (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 472-477 
    Details
    ISSN: 1432-1076
    Keywords: Vitamin K deficiency ; Intracranial haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Throughout Japan a total of 543 cases of vitamin K deficiency occurring in infants over 2 weeks of age were reported from January 1981 to June 1985. Of these cases, 427 showed no obvious reasons for vitamin K deficiency; this sort of case is known as “idiopathic vitamin K deficiency in infancy”. Another 57 cases had bleeding episodes due to vitamin K deficiency associated with obvious hepatobiliary lesions, chronic diarrhoea, long-term antibiotic therapy, etc; this sort is called “secondary vitamin K deficiency in infacy”. The third group, consisting of 59 cases, was made up of the socalled “near miss” type, in which a haemorrhagic tendency, without any obvious clinical haemorrhage, was discovered by Normotest, at the time of mass screening in most cases. In the idiopathic group, 269 cases (63.0%) developed bleeding episodes between the 1st and 2nd months of age, and 387 cases (90.0%) were entirely breast-fed. Intracranial baemorrhage was observed in 353 cases (82.7%) of this group. Moreover, slight elevation of serum transaminase and direct type bilirubin levels were observed in the idiopathic group. Liver dysfunction of unknown origin may play some role in the onset of vitamin K deficiency in infancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441969
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 215-219 
    Details
    ISSN: 1432-1041
    Keywords: nilvadipine ; calcium antagonist ; essential hypertension ; antihypertensive drug ; stress ; cold pressor test ; haemodynamics ; plasma renin ; plasma noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immediate haemodynamic effects of the calcium antagonist nilvadipine have been studied in ten patients with established mild essential hypertension. Nilvadipine 4 mg p.o. reduced both the systolic and diastolic blood pressures within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate and cardiac index. The peak of blood pressure and total peripheral resistance reached during a cold pressor test were reduced by nilvadipine, but it did not affect the haemodynamic responsiveness to cold stimulation. Plasma renin activity was unaltered and the plasma noradrenaline concentration was increased only slightly. Thus, nilvadipine lowered blood pressure at rest and during cold stimulation as a result of arteriolar dilatation. The hypotensive effect at rest was associated with a reflex increase in heart rate and cardiac index.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637551
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of TZU-0460, a new H2-receptor antagonist, in patients with impaired renal function (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 709-712 
    Details
    ISSN: 1432-1041
    Keywords: TZU-0460 ; renal failure ; H2-receptor antagonist ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjects. These variables were not altered with renal impairment. Sixty percent of TZU-0460 given orally was excreted via the kidney, mainly by tubular secretion. The half-time of elimination was 3.94 h in normal subjects, and was prolonged to 12.13 h in severe renal failure (creatinine clearance below 30 ml/min/1.48 m2). Dosage adjustment of TZU-0460 is necessary in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608220
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Immunoactivity of polymer microspheres with their hydrophilic/hydrophobic heterogeneous surface sensitized with an antibody (1987)
    Springer
    Colloid & polymer science 265 (1987), S. 1061-1066 
    Details
    ISSN: 1435-1536
    Keywords: Polymer emulsion ; hydrophilicity ; heterogeneousstructure ; immunomicrosphere ; agglutinability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Styrene/2-hydroxyethyl methacrylate polymer microspheres consisting of various polymer compositions were produced by emulsifier-free seeded emulsion polymerization technique. Using these microspheres, which should have hydrophilic/hydrophobic heterogeneous surface, the effects of surface hydrophilicity on the main, fundamental requirements for an immunomicrosphere — high colloidal stability, sensitive immunologic agglutinability and insensitive non-specific agglutinability — were studied in detail. There was a region of the surface hydrophilicity that satisfied the three requirements simultaneously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01417463
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  • 9
    Electronic Resource
    Electronic Resource
    Preparation of micron-size monodisperse polymer microspheres having chloromethyl group (1989)
    Springer
    Colloid & polymer science 267 (1989), S. 193-200 
    Details
    ISSN: 1435-1536
    Keywords: Polymer emulsion ; polymer microsphere ; micron-size ; chloromethyl group ; dispersion polymerization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Micron-size monodisperse polymer microspheres having chloromethyl groups thereon were prepared by two-step polymerization process as follows. First, micron-size monodisperse polystyrene particles were prepared by dispersion polymerization with 2,2′-azobisisobutyronitrile as initiator in ethanol-water medium in the presence of poly(acrylic acid) as stabilizer under various conditions. Secondly, in the presence of the 1.9-Μm monodisperse polystyrene particles produced under the optimum conditions, seeded copolymerization for styrene and chloromethyl styrene was carried out. The seeded copolymerization proceeded smoothly without producing new particles, and it was confirmed by x-ray photoelectron spectroscopy that the chloromethyl group existed more at the surface of the produced microsphere than at that of film cast from the benzene solution in which the microspheres were dissolved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410575
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Deletion 14q(q24.3 to q32.1) syndrome: significance of peculiar facial appearance in its diagnosis, and deletion mapping of (α1-antitrypsin) (1986)
    Springer
    Human genetics 〈Berlin〉 74 (1986), S. 190-192 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A 10-month-old Japanese boy who had interstitial deletion of the long arm of chromosome No. 14; 46,XY, del(14)(pter»q24.3::q32.1»qter) is reported. A peculiar facial appearance, including round face, frontal hypertrichosis with thick eyebrows, horizontal narrow palpebral fissures, a short bulbous nose with a flat nasal root, and mild micrognathia, appeared to be common with the two previously reported cases. We stress the significance of this peculiar facial appearance in the diagnosis of 14q-(q24.3 to q32.1) syndrome. The level of α1-antitrypsin in the patient was only about half of that of his parents and controls, and the Pi locus was tentatively assigned to band 14q32.1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282092
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    Paper (German National Licenses)
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