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  • 1985-1989  (1)
  • 1980-1984  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Evidence for the role of noradrenaline in some effects of quipazine (1980)
    Springer
    Psychopharmacology 67 (1980), S. 307-310 
    Details
    ISSN: 1432-2072
    Keywords: Quipazine ; Antidepressants ; NA ; 5-HT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These three responses are considered to be predictive of an antidepressive action; in these three tests the effects of quipazine are inhibited by d,l-propranolol but not by d-propranolol or methysergide. Quipazine, in mice pretreated with pargyline, induced head twitches which were inhibited by methysergide but not by d,l-propranolol. Quipazine, in addition to its well-known serotonergic effects, seems to have beta-adrenergic properties which should be kept in mind when this drug is used as a pharmacological tool and which suggest that the beta-adrenergic system is implied in depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431273
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Troleandomycin-triazolam interaction in healthy volunteers: Pharmacokinetic and psychometric evaluation (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 389-393 
    Details
    ISSN: 1432-1041
    Keywords: triazolam ; troleandomycin ; benzodiazepines ; antibiotics ; drug interaction ; pharmacokinetics ; first-pass effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seven healthy volunteers received a single oral dose of triazolam 0.25 mg after 7 days on troleandomycin 2 g/day p.o. or placebo in a double-blind cross-over study. Plasma triazolam and psychometric and memory tests (including Critical Flicker Fusion threshold, Choice Reaction Time, Digit Symbol Substitution and Self-Rating Scales) were assessed at regular intervals after the final treatment. Troleandomycin was found to prolong the psychomotor impairment and amnesia produced by triazolam. There was a significant enhancement of the AUC, the peak concentration and the delay to tmax of triazolam after 7 days treatment with troleandomycin compared to placebo. Thus, there is a pharmacokinetic interaction, and the combination of triazolam and troleandomycin should be avoided or the dose of triazolam should be adjusted. The most likely mechanism is a diminished hepatic first-pass effect, and a decrease in the apparent oral clearance of triazolam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543975
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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