Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • 1985-1989  (1)
  • 1975-1979  (2)
Datenquelle
Materialart
Erscheinungszeitraum
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    COLLAGENASE PRODUCTION BY HUMAN SYNOVIAL TISSUES (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 256 (1975), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1975.tb36056.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    T lymphocytes in synovia of patients with rheumatoid arthritis (1988)
    Springer
    Springer seminars in immunopathology 10 (1988), S. 169-180 
    Details
    ISSN: 1432-2196
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Conclusions The observation that rheumatoid synovial-derived lymphocytes display clonal dominance may have important implications in the understanding of the underlying pathogenic processes in RA. Isolation of the relevant T cell clones will allow further characterization including the development of anti-clonotypic mAb which could be used for diagnostic and possibly even for therapeutic purposes. Functional analysis of the clones could be used as an approach to identify the antigen(s) that trigger the disease. Our observations, however, raise a number of points. First, the detection of clonal dominance in a T cell population within a tissue or in blood has been considered a marker of malignancy [9, 13]. Recent studies of several skin diseases suggest that T cell oligoclonality observed in some of these lesions represents a selected repertoire of responding T cells; our study shows that T cell clonality is not restricted to lymphoproliferative diseases but may indeed be a feature of certain inflammatory processes as well.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01857222
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Regulation of hormone-induced cyclic AMP response to parathyroid hormone and prostaglandin E2 in cells cultured from human giant cell tumors of bone (1979)
    Springer
    Calcified tissue international 29 (1979), S. 193-200 
    Details
    ISSN: 1432-0827
    Schlagwort(e): cyclic AMP ; Parathyroid hormone ; Prostaglandin E2 ; Down regulation ; Bone cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Cells dispersed from human giant cell tumors of bone and grown in monolayer culture increase intracellular cyclic AMP (cAMP) when incubated with parathyroid hormone (PTH) or prostaglandin E2 (PGE2). When cells are continuously exposed to PTH, cAMP levels increase acutely but then decrease rapidly to pretreatment values despite continued presence of hormone or addition of new hormone. Preincubation of cells with PTH for periods as short as 10 min results in a decrease in the capacity of cells to increase cAMP content when re-exposed to maximal stimulatory concentrations of PTH. The decrease in the magnitude of the PTH-induced cAMP response observed in cells pretreated with this hormone is dependent on the concentration of PTH present during the pre-incubation. The loss of cAMP response in cells pre-treated with either PGE2 or PTH is hormone specific in that cells made refractory by pretreatment with one hormone still increase cAMP content when exposed to the other. Although the cells are not releasing measurable amounts of prostaglandins into the medium, pretreatment with indomethacin results in an increase in the magnitude of the cAMP response to PGE2. The PTH-induced cAMP response is not affected by indomethacin pre-treatment. The loss of PTH responsiveness produced by hormone preincubation is consistent with the phenomenon of “down-regulation” observed with ligand-receptor interactions in a variety of tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02408080
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...