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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 29 (1985), S. 181-185 
    ISSN: 1432-1041
    Keywords: althesin ; steroid binding globulins ; drug interaction ; steroid anaesthetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were measured in human serum. In 8 male patients, the effect of i.v. administration of Althesin (a mixture of Alfx and Alfd) on the transport of testosterone (T) and cortisol (F) was studied. Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (106M−1). A significant change in the percentage of unbound T was observed during Althesin infusion, with no change in total T concentration or in the TeBG binding parameters. The results suggest that by interaction with TeBG binding sites Alfx and/or Alfd displaced T bound to TeBG, and transiently increased the percentage of unbound T. A significant increase in the concentration of F was observed during althesin infusion, while the percentage of unbound F and the CBG binding parameters were unchanged. The dose of Alfx and Alfd used was not sufficient to alter the transport of F during brief althesin anaesthesia in men.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 36 (1986), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Treatment of Clostridium acetobutylicum with allyl alcohol allowed the selection of mutants which were unable to produce n-butanol, whereas the synthesis of acetone and ethanol was unaffected. Enzymatic investigations revealed that all mutant strains were devoid of butyraldehyde dehydrogenase or showed a very low activity of this enzyme as compared to the wild type.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Czechoslovak journal of physics 16 (1966), S. 697-722 
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Zusammenfassung Eine allgemeine Gleichung der Rekombinationsverluste in p-i-n-Detektoren wurde abgeleitet, die bei Kenntnis der Lebensdauer der Ladungsträger in der i-Schicht gestattet, diese Rekombinationsverluste zu berechnen. Für einzelne Fälle von Teilchenbahnen wurden vereinfachte Beziehungen gefunden. Das Impulsspektrum bei Querbestrahlung wurde theoretisch abgeleitet und experimentell nachgewiesen. Einige Meßmethoden der Lebensdauer und Beweglichkeit von Ladungsträgern in p-i-n-Detektoren wurden auf Grund der Spannungsabhängigkeit der Rekombinationsverluste und der Durchlaufzeit entwickelt. Erstaunlich sind die gefundenen niedrigen Werte der Lebensdauern unter 2 μs, die auf Rekombinationszentren in den Silizium-i-Schichten hinweisen. Die Rekombinationsverluste wurden auch zur Messung der Homogenität von p-i-n-Detektoren herangezogen. Es wurden die statistischen Schwankungen der Rekombinationsverluste, Oberflächenrekombination sowie Temperatur- und Spannungsabhängigkeit der Impulsspektren qualitativ untersucht und über einige experimentelle Ergebnisse berichtet.
    Notes: Abstract The general solution for the recombination losses was derivsd and some simpler equations for the different cases of irradiation were found. The theoretical spectrum of pulses for irradiation perpendicular to the field as a result of the general solution was proved experimentally. Some new methods of measuring the lifetime and mobility in p-i-n-type counters by means of the voltage dependence of the recombination losses and the transit time and new methods of measuring the detector homogeneity were developed. Different influences on the fluctuations of recombination losses and energy resolution, surface recombination, and the voltage and temperature dependence of the pulse spectra are treated in turn.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 17 (1987), S. 1319-1320 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 15 (1985), S. 471-472 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-4927
    Keywords: Rattus norvegicus ; acid phosphatases ; genetic variation ; linkage studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A genetic locus controlling the electrophoretic mobility of an acid phosphatase in the rat (Rattus norvegicus) is described. The locus, designed Acp-2, is not expressed in erythrocytes but is expressed in all other tissues studied. The product of Acp-2 hydrolyzes a wide variety of phosphate monoesters and is inhibited by l(+)-tartaric acid. Inbred rat strains have fixed either allele Acp-2a or allele Acp-2b. Codominant expression is observed in the respective F1 hybrids. Backcross progenies revealed the expected 1:1 segregation ratio. Possible loose linkage was found between the Acp-2 and the Pep-3 gene loci at a recombination frequency of 0.36±0.06.
    Type of Medium: Electronic Resource
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