ISSN:
1420-9071
Keywords:
γ-Aminobutyric acid
;
bicuculline
;
picrotoxin
;
internal perfusion
;
competition blockade
;
channel blockade
;
frog dorsal root ganglion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for γ-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02005880
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