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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 99 (1989), S. S41 
    ISSN: 1432-2072
    Keywords: Negative symptoms ; Rating scales ; Fluperlapine ; Clozapine ; Haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concept of negative symptoms tries to operationalize a deficit syndrome observed in schizophrenia, but also in other disorders. The instruments for the measurement developed so far are unclear in their dimensional structure and validity. Further methodological development is needed. A new scale for measuring negative symptoms was derived from the AMDP-system and applied to results of drug trials with clozapine, fluperlapine, and haloperidol. The three drugs were equally effective on negative symptoms of acute and chronic schizophrenics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 238 (1989), S. 285-293 
    ISSN: 1433-8491
    Keywords: Insomnia ; Epidemiology ; Prospective study ; Classification ; Prevalence ; Symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study describes sleep behaviour and insomnia in a representative cohort of a Swiss population. Interviews were carried out prospectively from age 20–21 to 27–28 years, starting with 292 males and 299 females. Females usually go to bed earlier and sleep 30 min longer than males. Taking into account length and periodicity of insomnia we can distinguish occasional insomnia (OI), repeated brief insomnia (RBI), and continued insomnia (CI), defined by operational criteria. The prevalence of sleep problems is stable from age 21–28, at 36%–40%. CI (prevalence 8%–10%) and RBI (13%–19%) are both medical problems in terms of treatment by professionals (10%–17%) or self-medication (7%–12%). The majority of insomniacs cope with sleep problems in various other ways. Frequency and patterns of symptoms of insomnia are described.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1985), S. 295-298 
    ISSN: 1433-8491
    Keywords: Schizophrenia ; Schizoaffective disorder ; Affective disorders ; Independent transmission of psychosis ; Genetics and psychosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An evaluation was made of schizophrenics (140), schizoaffectives (40), unipolar depressives (59), and bipolars (30), and their relatives who had a chart diagnosis of psychosis or depressive neurosis. The purpose was to determine whether the psychosis (delusions and hallucinations) was transmitted independently of the illness itself. If this were true, there would be an excess of pairs of probands and relatives both positive for psychosis and pairs of relatives and probands both negative for psychosis when compared to relatives and probands who were not concordant for the variable. This was found to be true in schizophrenia and schizoaffective disorder and is probably the result of the simple transmission of an illness which includes the presence of psychotic symptoms in the definition. Thus, this would be a manifestation of the genetic propensity in schizophrenia. For the affective disorders there was no evidence that psychotic probands were more likely than the nonpsychotic to have psychotic relatives. So far the reason why some patients have psychosis and others not in the affective disorders remains unexplained.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1985), S. 299-302 
    ISSN: 1433-8491
    Keywords: Schizophrenia ; Schizoaffective disorder ; Unipolar depression ; Bipolar disorder ; Mood-congruent and incongruent psychotic symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An examination was carried out on 140 schizophrenics, 34 schizoaffective manics, 6 schizoaffective depressives, 59 unipolars, and 30 bipolars to determine the variables of affective states and mood-congruent and mood-incongruent psychotic symptoms. These patients had been admitted to a hospital in Zürich and were systematically diagnosed, using both clinical and computer-derived systems. Forty-eight patients (18%) had both mood-congruent and incongruent psychotic symptoms. However, the affective disorders usually showed mood-congruent symptoms and the schizophrenics the mood-incongruent types. The schizoaffectives were likely to show both types. There was a marked dissociation between affective states and mood congruence in the schizophrenics. Though the majority of these patients showed depressive syndromes, they were quite unlikely to have mood-congruent symptoms. Likewise, 25% of the schizophrenics had manic-like syndromes, which contrasted with the fact that they rarely had mood-congruent psychotic delusions and hallucinations.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1985), S. 341-347 
    ISSN: 1433-8491
    Keywords: Schizophrenia ; Social disability ; Longitudinal research design ; Case-finding ; Control sample
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Psychiatric University Hospital Zürich (‘Burghölzli’) is taking part in the ‘WHO Collaborative Study on the Assessment and Reduction of Psychiatric Disability’. This multicenter project aims to assess the development of social disability for schizophrenic psychoses of relatively recent onset. This paper provides a brief review of underlying concepts, the prospective procedure, and the screening criteria applying to all centers. The research team at ‘Burghölzli’ has greatly extended the general design. Apart from the “obligatory” assessment of 69 first admitted schizophrenics (initial assessment on first hospitalization or outpatient treatment and follow-ups after 1, 2, and 5 years) we have also interviewed a control sample of 60 healthy persons (including a 2-year follow-up) and an ‘extreme’ sample of 46 chronic schizophrenic outpatients legally entitled to disability pension. Moreover, we have used several supplementary assessment instruments. This paper is to discuss the purpose of our extended research design. All cohorts are described with respect to screening criteria, sampling procedure, and some basic characteristics; furthermore, a review is given of the additional assessment instruments. It is intended to provide basic information for subsequent papers dealing with results from the study.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 235 (1985), S. 179-186 
    ISSN: 1433-8491
    Keywords: Minor depression ; Major depression ; Anxiety disorder ; Overlap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A representative sample of 456 persons from the normal population aged 22 and 23 years was used to study the overlap of depression with anxiety disorders. The 1-year prevalence rate for major depression (DSM-III), minor depression, and anxiety disorder together was 16.4%. The observed cases of major depression cooccurred in 36% with anxiety disorder, the cases with minor depression in 60%. On the level of symptoms assessed by a semistructured clinical interview and on the level of self-assessed items of the symptom check list SCL-90, the overlap was even greater. The main finding was that subjects with both diagnoses, depression and anxiety disorder, were more severely affected in general. Discriminant analyses of the SCL-90 scales together with the qualitative distribution of SCL items characterizing depression, anxiety, or phobia, did not disprove the hypothesis of a continuum.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 235 (1985), S. 171-178 
    ISSN: 1433-8491
    Keywords: Prevalence rates ; Anxiety disorders ; Agoraphobia ; Panic attacks ; Symptomatology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From data collected within the frame of a longitudinal epidemiologic study of a representative sample population of young adults (the Zurich Study), anxiety disorders—anxiety and phobic states—were analyzed. The current prevalence rate was found to be 2.9% for anxiety states and 4.3% for phobic states, totaling 7.2%. Because of their anxiety disorders, one-fifth of the cases had undergone treatment during the preceding 12 months. Substantial difficulties arose, from the point of view of classification. The currently used categories, such as anxiety states, panic attacks, agoraphobia, simple phobia, social phobia, have more in common than differing symptoms. On a syndromal level, numerous overlapping configurations resulted which can only be artificially forced into the aforementioned diagnostic classes of anxiety disorders. On the symptom level, merely a few operationalized items defined these categories. In this way, most of a broad identical ‘nonspecific’ symptomatology was not taken into account. This was exemplified by a comparison of anxiety states and agoraphobia. In fact, these two groups did not differ significantly in many symptoms or in SCL-90 profiles, but did show a highly significant difference from control samples. Both groups suffered to the same great degree from depressive, cardiovascular, and gastrointestinal symptoms. We doubt whether any forced categorical diagnostic differentiation of anxiety and phobic states is at all reasonable.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1985), S. 348-356 
    ISSN: 1433-8491
    Keywords: Premorbid social adjustment ; First onset schizophrenia ; Normal control sample
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The assessment of premorbid adjustment in schizophrenia has gained increasing interest in psychiatric research. Numerous studies have provided evidence on the predictive power of premorbid adjustment in the course and outcome of schizophrenic psychoses, but only little systematic research has been done on this topic comparing schizophrenics and healthy persons. In this study we have analyzed the premorbid life situation and social adjustment of 69 first onset schizophrenics in contrast to 60 healthy subjects. The comparisons between these samples showed significant differences for nearly all areas assessed, indicating a premorbid disablement of the schizophrenics both for quantitative and qualitative aspects of social functioning. Compared to that of healthy people, the size of the schizophrenics′ social network is markedly reduced and often characterized by a strong link to their family of origin. In general, the schizophrenics fail to establish close relationships or engage in social contact. Moreover, they tend to withdraw from existing relationships, especially heterosexual ones. Even when the schizophrenics appear quite normal on formal criteria (such as partnership or employment situation), further analyses often reveal problems, e.g., conflicts at work or reticence with partners. The results of this study clearly demonstrate the necessity of assessing not only formal criteria but also behavioral patterns and emotions of the persons concerned.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1985), S. 408-416 
    ISSN: 1433-8491
    Keywords: Brief depressive episodes ; Dysthymic disorders ; Prevalence rates ; Validity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary How common and how significant are brief depressive episodes (BDE) lasting less than 2 weeks? The authors propose splitting the BDE into two groups: one occurring monthly over 1 year of observation, termed ‘recurrent brief depression’BD), and those occurring less frequently, labeled ‘recurrent brief depression’ BD). From a medical point of view, the RBD are a relevant group. Different thresholds of definition are tested, the narrowest of which (including occupational impairment and predetermined minimum number of symptoms) is accepted for ‘case’-definition. The such defined RBD (SYM) group differs from major depression only by length and frequency of episodes. In a young cohort, its 1-year prevalence rate was found to be 4.4% (males 3.9%, females 4.9%). One-third of these cases needed treatment, a fourth suffered from pronounced subjective and social impairment as well as from persistent suicidal ideation. The self-reporting of subjective impairment, assessed with the SCL-90 symptom inventory and an analog-rating, yields high scores which are in no way inferior to major depression diagnosed with RDC, DSM-III or EDE (SYM) criteria. The RBD (SYM) demonstrate less hypomania than the major depressive disorders. On the other hand, a family history of depression is equally frequent across all groups. The validity of the RBD (SYM) group has yet to be confirmed by a follow-up study, and further research is needed to delineate it from secondary depression. The findings largely support the hypothesis of a continuum from mild and short to more severe, longer lasting depressive syndromes, but they do not exclude heterogeneity of RBD (Angst and Dobler-Mikola 1984b). The diagnostic concept of the RBD and the ‘dysthymic disorders’ of DSM-III are discussed. The similarity between RBD (SYM) and major depression questions the validity of the 2-week duration criterion.
    Type of Medium: Electronic Resource
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