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  • 1
    Electronic Resource
    Electronic Resource
    Stimulating effect of intermediate-density lipoproteins (IDL) from hyperlipemic plasma on hepatic lipase (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 530-533 
    Details
    ISSN: 1432-1440
    Keywords: Hepatic lipase ; Lipoproteins ; Hyperlipemia ; Intermediate-density lipoproteins (IDL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The main lipoprotein density classes, namely very-low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), high-density lipoproteins2 (HDL2) and HDL3 were investigated with respect to their influence on hepatic lipase (HTGL) activity in vitro. Lipoproteins from pooled normal plasma (NP) and from pooled hyperlipemic plasma (HP) were prepared by means of sequential ultracentrifugation. Hepatic lipase was determined radioenzymatically after preincubation with protamine sulfate. It could be demonstrated that IDL from HP were able to stimulate HTGL activity by approximately 100% above the baseline value. HDL3 from both NP and HP revealed an inhibiting effect on HTGL activity. VLDL, LDL, and HDL2 exhibited no significant effect on HTGL activity. It is speculated that HTGL could possibly represent a second pathophysiological pathway for the catabolism of IDL in hyperlipemia but this presumption is supported by only a few investigations in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713062
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of biosynthetic human proinsulin on plasma lipids in type 2 diabetes mellitus (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 1171-1174 
    Details
    ISSN: 1432-1440
    Keywords: Cholesterol ; Diabetes mellitus ; HDL-Cholesterol ; Proinsulin ; Triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma cholesterol, triglycerides, HDL2-cholesterol, and HDL3-cholesterol were studied in 18 patients with Type 2 diabetes. Prior to entering the clinical trial, the study subjects were in stable control under a fixed mixture of 20% regular and 80% NPH (isophane) biosynthetic human insulin twice daily. The patients were randomized to treatment with either biosynthetic human proinsulin or biosynthetic human NPH insulin (controls) twice daily. Glucose control was kept constant in both groups throughout the study. Of the nine patients treated with proinsulin, eight exhibited a decrease of plasma triglycerides (median decrease by 0.13 mmol/l). In contrast, all nine controls showed a rise (median increase by 0.69 mmol/l) of plasma triglycerides (p〈0.001). In keeping with the fall of plasma triglycerides, HDL2-cholesterol rose in all but one proinsulin-treated patients. Both treatment modalities reduced HDL3-cholesterol with a median decrease of 0.20 mmol/l (p〈0.01) with proinsulin and 0.26 mmol/l with NPH insulin (p〈0.05). We conclude that human proinsulin is able to reduce plasma triglycerides and to increase HDL2-cholesterol in the majority of patients with Type 2 diabetes and thus appears to alter favourably risk factors for coronary heart disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727664
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In vitro human polymorphonuclear leukocyte chemokinesis and human monocyte chemotaxis are different activities of aminoterminal and carboxyterminal substance P (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 340 (1989), S. 185-190 
    Details
    ISSN: 1432-1912
    Keywords: Tachykinins ; Calcitonin gene related peptide ; Neutrophils ; Monocytes ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Polymorphonuclear leukocytes (PMNL) are a component of the inflammatory response to neurogenic mediators. Using the micropore filter approach, the authors studied the chemoattracting properties of tachykinins, including substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), and that of calcitonin gene-related peptide (CGRP) for human PMNL in vitro and now show that SP in near nanomolar concentrations stimulates locomotion of human PMNL. Locomotion of PMNL is induced by SP, aminoterminal SP (1–9) and the SP receptor antagonist [d-pro2, d-trp7,9]-SP (DPDT) but not by carboxyterminal SP (3–11), NKA, NKB, or CGRP suggesting that the aminoterminal amino acids arginine and proline, are essential residues of SP in activation of PMNL locomotion. In contrast, the migratory effect of SP on monocytes resides in the carboxyterminal SP amino acid sequence, which is in agreement with carboxyterminal, SP receptor-mediated chemotaxis of human monocytes previously shown by others. From the known structure-activity relationships for SP receptors it is concluded that induction of PMNL migration by SP does not involve neurokinin-1 (NK-1), NK-2 or NK-3 receptors. “Checkerboard” analysis reveals that PMNL locomotion by SP is not dependent on concentration gradients and thus represents chemokinesis, which is enhancement of speed and/or frequency of locomotion. One cannot exclude that this action of SP on PMNL is mediated by the aminoterminal sequence via yet unknown SP “receptors”. Since structure-activity relationships appear to be similar to the mast cell degranulating actions of tachykinins, which also critically depend on the aminoterminal sequence, it may correspondingly be regarded as non-receptorial mechanism, due to membrane interaction of the basic groups in the N-terminal region of the peptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168967
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Surface glycoproteins (S-GP) on normal and malignant human leukocytes (1985)
    Springer
    Annals of hematology 50 (1985), S. 157-168 
    Details
    ISSN: 1432-0584
    Keywords: Galactose-oxidase technique ; Surface glycoproteins ; Human leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study aimed to investigate high molecular weight surface glycoprotein (S-GP) patterns on various types of human leukocytes. S-GP were externally labelled by the Galactose-oxidase-NaB3H4 technique. Results based on the analysis of 120 samples derived from different types of normal and malignant leukocytes indicate that (i) the relative expression of high molecular weight S-GPs changes during haemopoietic cell differentiation and (ii) to some extent these changes enable the classification of human leukocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320072
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of human plasmalipoproteins on erythropoietic progenitor cells in serum-free cultures (1986)
    Springer
    Annals of hematology 52 (1986), S. 191-195 
    Details
    ISSN: 1432-0584
    Keywords: Human bone marrow cells ; Erythropoiesis ; Serum-free medium ; CFU-e ; BFU-e
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to investigate the influence of human lipoproteins on CFU-e and BFU-e proliferation from human bone marrow in a serum-free system. In our previously described miniaturized agar system the main lipoprotein-density-classes from human plasma, namely very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), low density lipoproteins (LDL), high density lipoproteins2 (HDL2) and HDL3 and a mixture of all the five lipoproteins were added in rising concentrations (from 1/10 to normal human plasma concentration) to serum-free medium containing delipidated and deionized bovine serum albumin (BSA), iron saturated transferrin and erythropoietin. The results demonstrate that all lipoproteins markedly increased the CFU-e and BFU-e proliferation after 7 and 14 days of incubation, respectively. Moreover, the lipoproteins induced a shift towards a lower threshold concentration of erythropoietin. Serumlike conditions were obtained if LDL and the mixture of lipoproteins were added to serum-free medium. Furthermore, in the serum-free cultures a maturation to the mature erythrocyte could be found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320536
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    Paper (German National Licenses)
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