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Notes: [Auszug] BECAUSE of its proximity, the Sun inun-dates us with data and with theoretical problems. Few possess the diverse know-ledge of physics required to understand and lucidly explain these problems; in consequence, most recent books on general solar physics have been collections of chapters by ...

Notes: Summary Four monoclonal antibodies specific for somatostatin have been produced and characterized. These antibodies were used to assess the anatomical relationship of somatostatin-containing cells in the pancreas and gastrointestinal tract of man, baboon and rat with ten other peptide-containing endocrine cells. The peptides investigated were gastrin, cholecystokinin, motilin, secretin, neurotensin, gastric inhibitory polypeptide, gut-glucagon, pancreatic glucagon, pancreatic polypeptide and insulin. The only regions in which somatostatin cells were seen in close contact with another endocrine cell were in the pancreas and the gastric antrum. In the pancreas somatostatin cells were commonly seen in close contact with insulin, glucagon and pancreatic polypeptide cells and infrequent contact was demonstrable with the gastrin-immunoreactive cells in the antrum of both rat and man. In all other cases no evidence was obtained for a close anatomical relationship between somatostatin cells and the other enteroendocrine cells.

Notes: [Auszug] As the Sun rises towards its peak magnetic activity, solar oscillation observers mono-tonically increase their efforts as too, it seems, do authors of solar physics books. The past few years have seen several new monographs on aspects of the subject at advanced student and introductory research ...

Notes: Summary Calcitonin gene-related peptide-like immunoreactivity was demonstrated in in sensory nerve fibers in the epidermis and dermis as free nerve endings and around blood vessels and hair follicles of the human finger pad and arm skin. The vast majority of the calcitonin generelated immunoreactive fibers was shown to display also substance P-like immunoreactivity and a few fibers in the dermis were somatostatin positive. No fibers displaying both substance P and somatostatin-like immunoreactivity were found but a few substance P immunoreactive fibers in the dermis-epidermis region were found to contain also vasointestinal polypeptide-like immunoreactivity. In the sweat glands, abundant calcitonin gene-related peptide positive, but substance P negative, fibers were observed with a similar distribution pattern as the vasoactive intestinal polypeptide immunoreactive fibers and these fibers were suggested to be of sympathetic origin.

Notes: Summary The medulla oblongata and pons of colchicine treated rats were analyzed with a doublestaining technique using mouse monoclonal antibodies to somatostatin and rabbit polyclonal antibodies raised against methionine-enkephalin. Numerous cells reacted with both antisera but cells reacting with only one antiserum were also observed. Double-stained cells were most frequently encountered at all levels of the nucleus tractus solitarii, in a well defined group in the caudal medullary reticular formation, along the lateral ventral surface of the medulla oblongata, dorsolateral to the inferior olive and in the nucleus raphe magnus. These findings provide further examples of coexistence of two peptides and indicate the possibility that somatostatin-and enkephalin-like peptides are co-released.

Notes: Summary The β-cells of the pancreatic islets have been shown to contain γ-aminobutyric acid (GABA) together with insulin. Autoradiographic analysis indicated that high affinity GABA binding sites (GABA receptors) are not present in the pancreas. High affinity GABA uptake sites are present, not in β-cells, but in a few cells on the periphery of the islets. These observations cast doubt on the suggestion that GABA has a paracrine role in the pancreas.

Notes: Summary Somatostatin-like immunoreactivity was detected within the adrenal gland of the rat using specific monoclonal antibodies. Immunohistochemical studies demonstrated a few somatostatin-immunoreactive nerve fibers within the adrenal medulla. In addition, a large population of chromaffin cells in the cat adrenal medulla displayed intense somatostatin-like immunoreactivity. Similar cells were not observed in rat or guinea pig adrenal glands, although they were found in human material. The somatostatin-positive cells in the cat adrenal medulla often possessed short immunoreactive processes similar to those seen in somatostatin-immunoreactive paracrine cells of the gut. Characterization of the somatostatin-like immunoreactivity of the cat adrenal by high performance liquid chromatography and radioimmunoassay indicated that somatostatin-28 may account for over 90% of the observed immunoreactivity. It is suggested that somatostatin-28 may have a paracrine or endocrine role in the feline adrenal medulla.

Notes: Summary Neonatal and adult rat pancreatic islet cells were maintained in dissociated cell culture for up to three weeks. The unexpected occurrence of giant (40–50 μm) cells was noted, some of which reacted positively to an insulin antiserum, indicating the presence of insulin. The giant cells were amenable to study using the extracellular patch clamp technique, which was used to demonstrate a population of membrane channels gating outwardly directed current in these cells.

Notes: Abstract We describe the instrumental corrections which have to be incorporated for reliable correction and deconvolution of images obtained in the 16–22 keV and 22–30 keV energy bands of the Hard X-Ray Imaging Spectrometer (HXIS) aboard the Solar Maximum Mission (SMM). These corrections include amplifier gain and collimator hole size variations across the field of view, amplifier/filter efficiency, variation in effective collimator hole size and angular response with photon energy, dead-time, and hard X-ray plate transmission. We also emphasise the substantial Poisson noise in these energy bands, and describe the maximum entropy deconvolution/correction routine we have developed to establish the spatial structure which can be reliably inferred from HXIS data. Next we discuss the results of application of our routine to the three impulsive flare phases reported by Duijveman et al. (1982) as exhibiting hard X-ray ‘footpoints’, namely 1980, April 10, May 21, and November 5. Our main conclusions are: (1) Maximum entropy smoothing and Poisson noise data perturbations do not remove the main footpoint features in 16–30 keV nor change their basic morphology. However the results emphasise the asymmetry in footpoint size in the May 21 flare and confirm its possible presence in April 10. They also reveal the 3rd weak distant footpoint in the May 21 flare at an earlier time than found by Duijveman et al. When the 16–22 and 22–30 keV bands are analysed separately, however, it is found that the footpoints are much less visible above noise in the harder band - i.e. the footpoint spectra are steep. In the April 10 and November 5 flares they are steeper than either the spectrum of intervening pixels or the spectrum at higher energies measured for the whole flare by the SMM Hard X-Ray Burst Spectrometer (HXRBS). (2) The footpoint contrast with surroundings is less than found by Duijveman et al., despite image deconvolution, because of the maximum entropy smoothing of noise. (3) The 16–30keV HXIS footpoint fluxes in the three flares are respectively 28%, 17%, and 15% of the simultaneous HXRBS flare power-law spectrum extrapolated into this energy range. (4) Where Poisson noise is taken into account we find, by cross-correlating pixel count rates, that footpoint synchronism was either not provable at all, or substantially less close than reported by Duijveman et al. Next we considered the implications of these results for models of the footpoint emission. Contrary to Duijveman et al. we do not consider the HXIS ‘footpoint’ data as supporting a conventional thick target beam interpretation since: (A) The footpoint photon (and electron) fluxes are much less than expected from HXRBS extrapolation. This result casts doubt on recent models of chromospheric heating by electron beams which usually assume all of the HXRBS emission to come from HXIS footpoints. (B) The footpoint spectra for the April 10 and November 5 flares are much softer than the HXRBS spectrum and than the spectrum of intervening pixels, contrary to thick target predictions. (C) Contrary to Duijveman et al. footpoint synchronism does not demand an unreasonable Alfvén speed and so does not require non-thermal particles. In spite of these objections we also re-considered the constraints placed on the acceleration site conditions in a beam interpretation by return current stability and footpoint contrast in the summed 16–30 keV range. Using the smoothed maximum entropy contrast and taking explicit account of coronal thermal emission, we find maximum densities somewhat larger than Duijveman et al. estimated, and much higher maximum values of T e /T i . Regarding thermal interpretations we found: (a) Models involving continuous production of short-lived hot kernels in the arch top with Maxwellian tail electrons escaping to the footpoints could explain the 16–30 keV contrast with a rather higher energetic efficiency than a pure beam model. However, whatever the temperature distribution of hot kernel production, the model predicts footpoints harder than the arch summit, contrary to HXIS data. (b) A model with hot kernels produced in one limb of an arch can explain the asymmetry in footpoint size observed in May 21, and probably April 10, and is energetically even more efficient than (a) but is also inconsistent with the spectral data. (c) Finally we point out that HXIS footpoint data may be consistent with a purely geometric interpretation in an almost uniform arch filled with hot plasma.

Notes: Abstract It has often been stated, but never rigorously proven, that interpreting observed hard X-ray emission in terms of a thick-target source gives a lower limit to the flux of electrons which have to be injected into the source. The truth of this statement, for theburst-integrated emission, is rigorously established here. Also an explicit inversion for the injected electron flux in terms of the photon spectrum is given, for the case where all electrons traverse a single value of column density. This generalises the previous results for the thick- and thin-target limits. The use of the standard thick-target formalism for the interpretation of instantaneous (as opposed to burst-integrated) photon fluxes is also discussed. By considering the specific case of the thick-target trap model, it is shown that use of this formalism can either under-estimate or over-estimate the injected electron flux, at different times in the same event, but that integration of the inferred electron fluxes over the event nevertheless yields the true, burst-integrated electron flux.