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Digitale Medien

Karyotype instability of Chinese hamster cells during in vivo tumor progression (1987)

Bartholdi, Marty F. ; Ray, F. Andrew ; Cram, L. Scott ; [weitere]

Springer

Somatic cell and molecular genetics 13 (1987), S. 1-10

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Details

ISSN: 1572-9931

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract The extent of karyotype instability in spontaneously transformed Chinese hamster cells was determined after tumor formation by cytogenetic analysis of karyotype heterogeneity. The degree of karyotype heterogeneity among tumors formed in nude mice correlated with tumor latent period. The karyotypes of tumors formed after a short latent period by cells of high tumorigenic potential were similar to each other and to the injected cells. The karyotypes of tumors from cells of low tumorigenic potential and long latents periods were diverse, however. No chromosome aberration was common to every tumor. These results suggest that preneoplastic cells whose phenotypes are not directly capable of tumor formation can progress in vivo and that karyotype instability plays an important role in providing cell variants for tumor progression.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02422294

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