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  • 1985-1989  (4)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Stimulation of Histamine Receptors of Human Monocytoid and Hepatoma-Derived Cell Lines and Mouse Hepatocytes Modulates the Production of the Complement Components C3, C4, Factor B, and C2 (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 30 (1989), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influence of histamine (and the related agonists and antagonists) alone or in the presence of recombinant human interleukin 1α (IL-1α) and gamma interferon (IFN-γ) was studied on the production of complement components C3, C2, factor B, and C4 in vitro with human monocytoid cell line U937, hepatoma-derived cell line HepG2, and mouse hepatocytes. Both U937 and HepG2 cells responded to histamine through H1 and H2 histamine receptors. The effect of histamine on the biosynthesis and gene expression of complement proteins was predominantly enhancing via the H1 histamine receptors and inhibitory through the H2 receptors. The actual predominance of the histamine receptor involved (and the outcome of the ligand interaction) seemed to be greatly affected by the simultaneous activation of the cells by IL-1 or IFN-γ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1989.tb01207.x
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  • 2
    Electronic Resource
    Electronic Resource
    Action of histamine on PHA chemiluminescence response of blood mononuclear cells in autoimmune patients (1986)
    Springer
    Inflammation research 18 (1986), S. 254-257 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral blood mononuclar cells (PBMs) of patients suffering from autoimmune diseases showed significantly lower chemiluminescence response to PHA than the controls. High doses of histamine (10−5 M) inhibited the chemiluminescence while low doses caused a mild enhancement in all groups of patients. The preformed histamine content of the PMBs was not significantly higher in the patients than in the controls. Individually, a reverse correlation was found between the activity of the disease and the sensitivity of the cells to histamine. In very active cases, virtually no inhibition by histamine was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01988035
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of histamine on the T-cell colony formation of PHA-stimulated cells (1989)
    Springer
    Inflammation research 27 (1989), S. 215-217 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of histamine on T-cell colony formation was studied in human peripheral blood mononuclear cells. Histamine inhibited dose-dependently (10−4–10−6 M) the colony formation of PHA-stimulated T-cells. The inhibition was similar in normal controls and rheumatoid arthritis (RA) patients in spite of the fact that in RA the colony formation was significantly lower than in the normal controls. No increase of colony formation was observed at low concentrations (less than 10−7 M). Impromidine was less effective than histamine, and pyridylethylamine (PEA) was inactive. Cimetidine counteracted the effect of histamine while chlorpheniramine did not. The results show that colony formation may be inhibited through H2-receptors. This action may be of importance in cellular interactions in tissues with high local histamine concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222243
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  • 4
    Electronic Resource
    Electronic Resource
    The use of molecular probes in the study of the action of histamine on macrophages (1988)
    Springer
    Inflammation research 23 (1988), S. 328-330 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of histamine on the expressionin vitro of C2, factor B and C3 genes in murine resident peritoneal macrophages was investigated. By measuring the levels of specific mRNA and the amount of the biosynthetically labelled gene products, we found that histamine decreases the biosynthesis of C2 and factor B. However, histamine had virtually no effect on the biosynthesis of C3 in the same cells. To clarify the mechanism of these effects, the H1 agonists (2-pyridylethylamine (PEA)and 2-methylhistamine), the H2-agonists (impromidine and 4-methyl-histamine), the H1-antagonist (chlorpheniramine) as well as the H2-antagonist (cimetidine) were also tested. We found that the inhibitory effect of histamine on C2 and factor B is produced only through H2 receptors. With the combination of histamine agonists and antagonists an, inverse effect via H1-or H2-receptors was determined on the biosynthesis of C3. H1-receptor stimuli enhanced, and the stimulation of H2-receptors inhibited, C3 biosynthesis. All effects were pretranslational since the same results were obtained on mRNA and protein levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02142578
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    Paper (German National Licenses)
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