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Autosomal recessive polycystic kidney disease (1989)

Kaplan, Bernard S. ; Fay, J. ; Shah, Vanita ; [et al.]

Springer

Pediatric nephrology 3 (1989), S. 43-49

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ISSN: 1432-198X

Keywords: Polycystic kidneys ; Congenital hepatic fibrosis ; Hypertension ; Hyponatraemia

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The clinical features of 55 cases of autosomal recessive polycystic kidney disease (ARPCKD) have been reviewed. Each had evidence of ARPCKD. The outcomes of 87% were known; 24 had died. Twenty-four of 31 were seen between 1980 and 1986; 7 could not be traced. Forty-five percent presented under 1 month; 38% between 1 month and 1 year; and 9 cases over 1 year. Hyponatraemia occurred in 15 out of 19 aged less than 3 months; hypertension occurred in 65%; splenomegaly in 47% of those surviving more than 3 months. Portocaval shunts were done in 5 aged 2–12 years. Thirteen died of renal failure, 6 under 1 year, and 7 between 1 year and 13 years. Life-table survival rates calculated from birth revealed that 86% were alive at 3 months, 79% at 1 year, 51% at 10 years, and 46% at 15 years. Calculations based on patients who survived to 1 year of age showed that 82% were alive at 10 years and 79% at 15 years. These results reveal an improved prognosis for a condition once assumed to be fatal.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00859625

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Characterization of poly(3,3-bisethoxymethyl oxetane) and poly(3,3-bisazidomethyl oxetane) and their block copolymers (1989)

Murphy, E. A. ; Ntozakhe, T. ; Murphy, C. J. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 37 (1989), S. 267-281

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: The homopolymers, poly(3,3-bisethoxymethyl oxetane) (polyBEMO), poly(3,3-bisazidomethyl oxetane) (polyBAMO), and triblock copolymers based on these homopolymers and a statistical copolymer center block composed of BAMO and 3-azidomethyl-3-methyl oxetane AMMO were synthesized and characterized by differential scanning calorimetry, modulus-temperature, optical microscopy, membrane osmometry, and solution and melt viscosity. The values of K and a for the Mark-Houwink equation were found to be 7.29 × 10-3 mL/g and 0.80, respectively, for polyBEMO at 25°C using number-average molecular weights. Glass transition temperatures were in the range -25 to -40°C and melting temperatures were between 65 and 90°C for all polymers. The melting temperature was found to increase as expected with molecular weight. Melt viscosities of triblock copolymers with polyBAMO end blocks were at least an order of magnitude lower than those with polyBEMO end blocks and clear optically, suggesting that the polyBAMO-based triblock copolymers formed one phase in the melt, while the polyBEMO-based triblock materials (milk white) phase separated. The addition of filler raised the melt viscosity to a level between that predicted by the Guth-Smallwood and the Mooney equations.

Additional Material: 9 Ill.