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  • 1985-1989  (5)
  • 1
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A number of criteria have been investigated to try to improve the uptake of radiolabelled antibodies by colorectal carcinoma xenografts. The in vivo behaviour of four antibodies was compared and found to vary. Two antibodies, 11-285-14 and 14-95-55, demonstrated specific uptake by the tumours. 11-357-5 was lost from the tumour after 72 h and the fourth antibody could not be iodinated without loss of activity. Neither increased time nor increased dose were shown to increase the uptake of antibody by tumours although the clearance of antibody from blood was shown to be more rapid than from tumour resulting in clearer backgrounds. Increased tumour:blood ratios were demonstrated by particular combinations of antibodies but the extent to which this occurred varied with the epitopes recognised. High carcinoembryonic antigen expressing xenografts did not show significantly higher uptake of antibody. This was shown to be due to the smaller size of these tumours and associated decreased vascularity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 9 (1985), S. 512-513 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 9 (1985), S. 648-651 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 9 (1985), S. 792-793 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'adénocarcinome du cardia est d'un pronostic particulièrement sévère car le traitement n'est souvent que palliatif. L'étude présentée par les auteurs concerne 736 cas de cancer du cardia opérés de 1960 à 1969. Cinquante-huit pour cent des malades présentaient des lésions avancées. Dans trente-six pour cent des cas il fut procédé à une résection (265 cas). Le taux de la survie à 5 ans fut au total de 4.5% atteignant 9.8% après résection radicale. Chez les malades qui présentaient des lésions avancées la survie fut plus longue après résection qu'après intubation (p〈0.001) alors même qu'étaient présentes des métastases péritonéales ou hépatiques. La mortalité postopératoire (30 jours) de la résection ne fut pas supérieure à la mortalité consécutive à l'intubation. Ce fait suggère que la résection doit toujours être entreprise quand elle est possible.
    Abstract: Resumen El adenocarcinoma del cardias gástrico tiene pésimo pronóstico y su tratamiento frecuentemente es sólo paliativo. El présente estudio revisa 736 casos de carcinoma del cardias del Registre de Cáncer de Birmingham entre 1960 y 1969. Cincuenta y ocho por ciento de los pacientes presentaba enfermedad avanzada. La resección radical fue realizada en 265 (36%). La supervivencia a 5 años ajustada por edad para la totalidad de los casos fue de 4.5% y para los sometidos a resección fue de 9.8%. En los pacientes con enfermedad avanzada la resección paliativa apareció asociada con una más prolongada supervivencia que la simple intubación (p 〈 0.001) y esta diferencia se mantuvo aún en presencia de metástasis hepáticas o peritoneales. No hubo diferencia en las tasas de mortalidad a 30 días para aquellos sometidos a resección paliativa o a intubación; se sugiere que se emprenda la resección los casos en que sea factible.
    Notes: Abstract Adenocarcinoma of the gastric cardia has the worst prognosis of all sites, and treatment is often palliative. This study has reviewed 736 patients with carcinoma of the cardia registered with the Birmingham Cancer Registry during 1960–1969. Fifty-eight percent of the patients presented with advanced disease. Radical resection was accomplished in 265 (36%). The age adjusted 5-year survival for all patients was 4.5% and 9.8% for those undergoing radical resection. In patients with advanced disease, palliative resection was associated with a longer survival than for those treated by intubation (p 〈 0.001) and this difference was maintained even in the presence of liver or peritoneal metastases. There was no difference in the 30-day mortality rates for those undergoing palliative resection or intubation and it is suggested that resection be undertaken whenever possible.
    Type of Medium: Electronic Resource
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