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  • 1985-1989  (6)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 1548-1555 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have studied the various rates of formation and decay of ZnHg using a frequency doubled dye laser at 307.6 nm as a pump source for the zinc 3 P1 state. More specifically we have measured the rate of decay of the atomic 3 P1 state, the rate of three-body formation of excited ZnHg, the spontaneous emission coefficient of excited ZnHg, the rate of quenching of ZnHg by Hg atoms and the rate of biexcimer quenching. We have also carried out new measurements of the spectrum of excited ZnHg and of the intrinsic stimulated emission cross section.
    Type of Medium: Electronic Resource
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  • 2
    facet.materialart.
    Unknown
    Amsterdam : Periodicals Archive Online (PAO)
    Population research and policy review. 7:2 (1988:May) 189 
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Infection 17 (1989), S. 347-354 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung β-Laktamasen spielen in der bakteriellen Resistenz eine entscheidende Rolle; dies bestätigte sich erneut mit dem Auftreten von Breitspektrum-β-Laktamasen. Nach Erstentdeckung in der Bundesrepublik wurde SHV-2 in vier Kontinenten nachgewiesen; in mindestens 26 französischen Krankenhäusern trat CTX-1 (TEM-3) auf. Mehr als 12 weitere Enzyme wurden identifiziert. Die Bedeutung dieser neuesten Resistenz-Form wurde wahrscheinlich unterschätzt, da die meisten Stämme von Enterobakterien (vor allemKlebsiella pneumoniae nach Ergebnissen der MHK-Bestimmungen oder Hemmhofdurchmesser gegen Oxyimino-β-Laktame empfindlich zu sein schienen. Zwei Empfindlichkeitsmuster (CTX, CAZ) lassen sich mit dem Doppel-Blättchen-Synergismus-Test von Amoxicillin/Clavulansäure und Oxyimino-β-Laktamen ohne Schwierigkeiten nachweisen. In den Krankenhäusern haben sich Breitspektrum-β-Laktamasen ausgebreitet, die bei nosokomialen Enterobakterien-Stämmen (aus Urin-, Blut-, Wund- und Sputumkulturen), vorwiegend aus Intensivstationen, zu finden sind. Bei Ausbrüchen vonKlebsiella pneumoniae-Infektionen fanden sich zahlreiche Serotypen. Untersuchungen zur Verteilung der Breitspektrum-β-Laktamasen in Frankreich zeigten, daß CTX-1 (TEM-3) unter zehn Spezies verbreitet ist, während sich die Enzyme vom Typ SHV (SHV-2, SHV-3, SHV-4) vorwiegend inKlebsiella pneumoniae nachweisen lassen. BeiEscherichia coli bildeten die meisten Stämme Enzyme vom Typ CAZ. Manche Isolate bildeten zwei Breitspektrum-β-Laktamasen. Breitspektrum-β-Laktamasebildung durchKlebsiella pneumoniae, Salmonella undEscherichia coli wurde in Tunesien vor allem in Isolaten aus der Pädiatrie nachgewiesen; am häufigsten fand sich SHV-2, kürzlich wurden aber auch CTX-1 und zwei andere Typen mit isoelektrischem Punkt von 6,35 und 5,4 (Phänotyp CTX) identifiziert. Da diese Enzyme durch Plasmide kodiert sind, breitete sich dieser Resistenzmechanismus in Frankreich für CTX-1 zusammen mit anderen Resistenzmarkern aus (z. B. Resistenz gegen Netilmicin, Amikacin), was für SHV-2 nicht der Fall war. Bei Enterobakterien-Isolaten aus Tunis, vor allem den erstenSalmonella wien-Isolaten, war die Übertragbarkeit von Breitspektrum-β-Laktamasen offensichtlich seltener. 1988 wurde übertragbare Resistenz gegen andere Antibiotika wie Aminoglykoside festgestellt. Es scheint sehr unwahrscheinlich, daß die Verwendung neuerer Antibiotika das Auftreten von Breitspektrum-β-Laktamasen begünstigt.
    Notes: Summary β-lactamases play a major part in resistance, as recently redemonstrated by the emergence of extended spectrum β-lactamases. Since its discovery in FR Germany, SHV-2 has been reported from four continents and CTX-1 (TEM-3) was established in at least 26 French hospitals. More than 12 other enzymes have been individualized. The newest aspect of resistance was probably underestimated because most strains of enterobacteria (mainlyKlebsiella pneumoniae) appeared susceptible to oxyimino-β-lactams as suggested by MICs or diameters of inhibition zone sizes. The double-disk synergy test between amoxicillin/clavulanic acid and oxyimino-β-lactams was useful to easily detect two susceptibility patterns (CTX, CAZ). Extended spectrum β-lactamases isolated among nosocomial isolates of enterobacteria (urines, blood, wound, sputum cultures) mostly from intensive care units have spread through hospitals. If outbreaks were described, numerous serotypes were identified inKlebsiella pneumoniae. In France the distribution of extended spectrum β-lactamases showed that CTX-1 (TEM-3) was well distributed among ten species unlike SHV-type enzymes (SHV-2, SHV-3, SHV-4) preferentially detected inKlebsiella pneumoniae. A majority of strains produced CAZ-type enzymes inEscherichia coli. Some isolates produced two extended spectrum β-lactamases. In Tunisia extended spectrum β-lactamase producing strains were mainly identified among pediatric isolates ofKlebsiella pneumoniae, Salmonella andEscherichia coli; SHV-2 was predominant but recently CTX-1 and two other types with an isoelectric point of 6.35 and 5.4 (phenotype CTX) were individualized. Because plasmid-encoded, this mechanism was spreading in France among enterobacteria with other resistance markers (e.g. netilmicin, amikacin) for CTX-1 unlike SHV-2. The transferability of extended spectrum β-lactamases appeared to occur less frequently from isolates of enterobacteria issued from Tunis and particularly for the first isolates ofSalmonella wien. The transmissible resistance to other antibiotics such as aminoglycosides was demonstrated in 1988. It seems highly likely that the use of newer antibiotics favors the appearance of extended spectrum β-lactamases.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 224 (1986), S. 529-535 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several varieties of ocular pathology are associated with acquired cutaneous hypomelanosis (leukoderma; vitiligo). Our current study was undertaken to investigate the relationship between ophthalmologic disorders and a specific depigmentary phenomenon, the vitiligolike leukoderma of cutaneous melanoma. Over the past 14 years, eight patients with cutaneous melanoma and widespread areas of hypopigmentation were identified at the Pigmented Lesion Clinic of the Massachusetts General Hospital. The seven patients who underwent ophthalmologic examination had pigment-related ocular abnormalities. Among these were inflammations of the uveal tract in three patients, heterochromia in two, halo nevi of the choroid in one, and hypopigmentation and/or atrophy of the retinal pigment epithelium or choroid in four. Our findings demonstrate that ocular disease may be a component in a syndrome consisting also of cutaneous melanoma and vitiligolike leukoderma and suggest the need for complete ophthalmologic examinations in patients with melanoma and leukoderma.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 527-529 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 210 strains ofEnterobacteriaceae which were isolated in four hospitals and which showed reduced susceptibility to cefotaxime, high synergy was demonstrated between amoxicillin (20µg) + clavulanate (10µg) and cefotaxime (30µg) using a simple double-disk test. Isoelectric focusing on gel and specific iodometric detection using ceftriaxone identified four extended broad-spectrumβ-lactamases (isoelectric points 7.6, 6.3, 7.0 and 5.9) produced by the strains.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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