ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The fragmentation of two penicillins, ampicillin and amoxicillin, and their principal metabolites has been studied by a combination of liquid chromatography/thermospray mass spectrometry and tandem mass spectrometry. A high-resolution tandem mass spectrometer was used to obtain chemical ionization, fast-atom bombardment, and collision-induced dissociation mass spectra. Structural information and fragmentation mechanisms have been deduced from ions in the mass and collision spectra. This knowledge is useful in the analysis and identification of metabolites of ampicillin and related drugs in human body fluids.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200160175
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