ISSN:
0942-0940
Keywords:
Intracranial pressure
;
cerebrospinal fluid vasopressin
;
plasma vasopressin
;
hydrocephalus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The response of plasma and ventricular cerebrospinal fluid vasopressin concentration to short-time induced intracranial hypertension was studied in 8 patients with hydrocephalus, defined as ventricular enlargement on computerized tomography. In connection with measurement of conductance to cerebrospinal fluid outflow, the concentration of vasopressin in plasma and cerebrospinal fluid was measured during perfusion at a low (〈l0mmHg) and at a high (〉20 mmHg) intraventricular pressure level. Mean plasma vasopressin concentration was increased from 2.4±0.4pg/ml (SEM) during perfusion at the low pressure level to 4.2±0.8 pg/ml (p〈0.01) at the high pressure level. The cerebrospinal fluid concentrations of vasopressin at the low and high intraventricular pressure were 1.2 ±0.1pg/ml and 1.7±0.2 pg/ml (p〈0.05), respectively. However, only half of the patients responded to the increase in intraventricular pressure with an increase in cerebrospinal fluid vasopressin concentration exceeding 50%. The results of the present study suggest that an increase in the intracranial pressure might be a stimulus for vasopressin release in both the blood and the cerebrospinal fluid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01402305
Permalink
