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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 54 (1986), S. 91-98 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A spatio-temporal model of ganglion cell receptive fields is proposed on the basis of receptive field characteristics of cat retinal ganglion cells reported in our previous paper. The model consists of the linear and nonlinear mechanisms in the ganglion cell receptive field. The linear mechanism is assumed to be composed of antagonistic center and surround mechanisms. Then, by integrating these mechanisms we construct a spatio-temporal impulse response function of ganglion cell receptive field. Here we assume that spatio-temporal impulse response function may be factored into spatial and temporal terms. By Fouriertransforming the spatio-temporal impulse response function, we can obtain the spatio-temporal transfer function. Contrast sensitivity characteristics of X-and Y-cells in the cat retina may be explained by the transfer function.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 16 (1989), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nine periodontally affected subjects and eight healthy subjects were selected in order to examine the effect of initial periodontal treatment on occlusal sounds. Gingival Index, probing depth, tooth mobility and occlusal sound duration via an occlusal sound analyser were recorded at the baseline. The nine periodontal patients were then treated by plaque control, root planing with general scaling and were re-examined at 1 month and 3 months post-operatively.The following results were obtained:(i) The normal duration of an occlusal sound is less than 10 ms.(ii) Occlusal sounds of periodontal patients were of longer duration compared with the values in healthy subjects, but decreased and approached the normal value after treatment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 23 (1988), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The present study evaluated blastogenic responses and immunoglobulin production (IgG, IgM) by inflamed gingival lymphocytes from dogs. The excised tissues were cut finely, digested in collagenase for 60 min, then passed through a mesh, teased with a 24 G needle several times and centrifuged over a ficoll gradient. Responses to PHA, Con-A and PWM were assessed using peripheral blood lymphocytes (PBLs) and submandibular lymph node cells (SNLs) as controls. Blastogenesis was evaluated from the uptake of 3H-thymidine and the presence of IgG and IgM in culture supernatants was quantified using ELISA. The extraction procedure resulted in a mean 2.09 ± 0.44 × 105 lymphocytes per 100 mg tissue (wet weight). These cells had a mean viability of 84.4 ± 3.0%. The responses of PBLs and SNLs to PHA, Con-A and PWM were substantial, as expected, while the responses of gingival lymphocytes to any mitogen remained at the level of unstimulated lymphocytes. However, gingival lymphocytes produced and secreted IgG and IgM. IgG production by gingival lymphocytes was elevated when compared with those of PBLs and SNLs, while IgM production by gingival lymphocytes was less than PBLs and SNLs. The responses of PBLs and SNLs are not parallel to the response of gingival lymphocytes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 416 (1989), S. 153-157 
    ISSN: 1432-2307
    Keywords: Neoplasm metastasis ; Stomach neoplasms ; Meningioma ; Pancreatic neoplasms ; Thymoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two further two cases of the previously undescribed combination of tumour-to-tumour metastasis — gastric carcinoma metastatic to meningioma and pancreatic carcinoma to thymoma, are presented. The clinico-pathological characteristics of these cases are briefly discussed with a review of the literature.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1437-1596
    Keywords: 4-Hydroxymethamphetamine, metabolite of methamphetamine ; Analysis in body fluid, methamphetamine and 4-hydroxymethamphetamine ; 4-Hydroxymethamphetamin ; Amphetamin ; Methamphetamin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Pentadeuteriertes 4-Hydroxymethamphetamin (HMAMP-D5),1-(4-Hydroxyphenyl)-2-(methyl-D3-amino)propan-1,2-D2 wurde in hoher Ausbeute synthetisiert und als brauchbarer interner Standard im Rahmen der quantitativen Analyse von 4-Hydroxymethamphetamin, einem Hauptmetaboliten des Methamphetamins (MAMP) eingesetzt. Die gaschromatographisch-massenspektrometrische Untersuchung lieferte gut reproduzierbare Resultate. Weiterhin gelang die simultane Bestimmung von MAMP, Amphetamin(AMP), 4-Hydroxymethamphetamin(HAMP) und HMAMP in Körperflüssigkeiten bei Verwendung zweier interner Standards: HMAMP-D5 für HMAMP und HAMP, bzw. pentadeuteriertem Methamphetamin (1-Phenyl-2-(methyl-D3-amino)-propan-1,2-D2) für MAMP und AMP.
    Notes: Summary Pentodeuterated 4-hydroxymethamphetamine(HMAMP-d5),1-(4-hydroxyphenyl)-2-(methyl-d3-amino)-propane-1,2-d2 of high quality was prepared and proved to be a most useful internal standard for quantitative analyses of 4-hydroxymethamphetamine(HMAMP), a main metabolite of methamphetamine(MAMP). Highly reliable results were obtained by gas chromatography/mass spectrometry. Simultaneously we determined also MAMP, amphetamine (AMP), 4-hydroxyamphetamine(HAMP), and HMAMP in body fluids, using two internal standards, HMAMP-d5 for HMAMP and HAMP and pentodeuterated methamphetamine, 1-phenyl-2-(methyl-d3-amino)-propane-1,2-d2, for MAMP and AMP.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 98 (1987), S. 49-55 
    ISSN: 1437-1596
    Keywords: Tetrahydrofuran, in histologic materials ; Tetrahydrofuran, Nachweis in biologischem Material
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Der Einsatz und die Kombination von GC, GC/MS und Headspace-Variante ermöglicht die Routine-Analyse von Tetrahydrofuran (THF) in biologischem Material. Probleme mit der Headspace-Methode, die auf die beträchtliche Wasser- und Lipidlöslichkeit dieser Substanz zurückgehen, konnten durch eine Aussalz-Technik gelöst werden. Bei Konzentrationen von über 5 μg pro Probe wurde die Identifizierung massenspektrometrisch durchgeführt. Im Rahmen quantitativer Bestimmungen kam bei der GC Tetrahydropyran (Pentamethylen-oxid) bzw. bei der GC/SIM octadeuteriertes THF (TDF) als innerer Standard zum Einsatz. THF konnte bis zu 1 μg pro Probe mittels GC und bis zu 0,1 μg pro Probe mittels GC/SIM nachgewiesen werden. Bei Labortieren wurden Maximalspiegel von THF im Blut ungefähr 1 h nach oraler Applikation beobachtet; die Halbwertszeit lag bei etwa 5 h. Das Verteilungsverhältnis zwischen Gewebe und Blut war etwa 1,5–2 bei Fettgewebe und Niere bzw. praktisch übereinstimmend bei Gehirn, Leber, Milz und Muskulatur.
    Notes: Summary Routine analysis of tetrahydrofuran (THF) in biologic materials has become feasible using GC and GC/MS and the headspace method. Problems of the headspace method and this substance which has a high water-and lipid-solubility were overcome by using the salting-out technique. Identification was made by mass spectral examination, in case of concentrations over 5 μg per sample. For quantitative determinations, tetrahydropyran (pentamethylene oxide) was used as an internal standard in GC, and a stable isotopic substance, octadeuterated THF (TDF) in GC/SIM. THF was detected in 1 μg per sample by GC, and 0.1 μg per sample by GC/SIM. THF blood levels in laboratory animals reached their highest values about 1 h after the oral administration, and the half-life was about 5 h. Ratios of tissue levels to blood were ca. 1.5–2 in the adipose tissue and kidney, and fairly equal in the brain, liver, spleen, and muscle.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-1803
    Keywords: calcium entry ; myocardial cell injury ; membrane permeability ; calcium-activated neutral protease ; calcium-dependent phospholipases ; cyclooxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of Ca overload-induced myocardial cell injury under hypoxia was examined for the involvement of calcium-activated neutral proteases (CANP), calcium-dependent phospholipases (CDP) or prostaglandins with measuring45Ca entry, intake of biologically inert dye, nigrosin, into the cultured myocytes, as was useful for the quantification of sarcolemma permeability, and the release of creatine phosphokinase (CPK) to the culture medium. A Ca channel blocker, verapamil (1 and 10 μg/ml) or a Ca ionophore, A 23187 (0.5 to 4 μg/ml) dose-dependently decreased or increased both the Ca entry and nigrosin intake in accordance with the CPK release. Furthermore, the inhibitors against CANP, NCO-700 (2 and 20 μg/ml) that was demonstrated to permeate sarcolemma using14C-labelled reagent, against CDP, mepacrine (1 and 10 μg/ml) or against cyclooxygenase, indomethacin (1 and 10 μg/ml) caused no effect on the Ca entry, nigrosin intake nor CPK release under hypoxia. These results suggest that the Ca overdose into the myocardial cells potentiates their injury and it is not primarily related to the activation of CANP, CDP nor cyclooxygenase.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über unsere Studien zu Superinfektionen bei Infektionen der Atemwege, die von 1981–1984 behandelt wurden. Die isolierten Stämme vonStaphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis undStreptococcus faecium sowie von Glukose nicht fermentierenden gramnegativen Stäbchen wiePseudomonas aeruginosa waren resistent gegen Cephem-Antibiotika der dritten Generation. Es zeigte sich, daß diese Erreger in den Krankenhäusern weit verbreitet waren; sie wurden häufig aus Sputum, Lungenexzisaten und Herzblut isoliert. Untersuchungen zur Kolonisation des Sputums vor, während und nach der Therapie mit Cephem-Antibiotika der dritten Generation ließen eine Tendenz für das Auftreten dieser Bakterien im Anschluß an die Behandlung erkennen. Unter den grampositiven Kokken warS. faecium am resistentesten gegen diese Antibiotika,S. faecalis, S. epidermidis undS. aureus zeigten eine in der genannten Reihenfolge geringgradigere Resistenz. Die Inzidenz resistenter Isolate war 1984 höher als 1983, was auf eine jährliche Zunahme resistenter Bakterien schließen läßt.
    Notes: Summary This paper is a report on our studies on superinfections in respiratory tract infections treated during the years 1981–1984. The isolated strains ofStaphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis, Streptococcus faecium and glucose non-fermentative gram-negative rods such asPseudomonas aeruginosa were resistant to third-generation cephem antibiotics. These organisms proved to be widely distributed in hospitals and were frequently isolated from the sputum, excised lung and cardiac blood. The colonization of the sputum by bacteria in respiratory tract infections before, during and after treatment with third-generation cephem antibiotics revealed a tendency for these organisms to appear after treatment. Among the gram-positive cocci,S. faecium was most resistant to these antibiotics, followed byS. faecalis, S. epidermidis andS. aureus in that order. The incidence of resistant isolates in 1984 exceeded that in 1983, suggesting an annual increase in resistant bacteria.
    Type of Medium: Electronic Resource
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