ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Specimens of gingiva from 78 lesions taken from 52 patients with chronic periodontitis and gingiva from clinically healthy subjects or subjects with gingivitis were obtained. The patients and control subjects were placed into three groups according to age. The numbers of IgE-bearing cells and other classes of immun-oglobulin-bearing cells were counted, and the ratios of those cells to the total numbers of infiltrating cells were determined. There was a predominance of IgG-bearing cells, followed by IgA-bearing cells; the numbers of IgM- and IgE-bearing cells were small. IgE-bearing cells were observed in gingivaI specimens with a small infiltration. In moderately and severely infiltrated lesions, IgE-bearing cells were observed most frequently in the specimens, and the ratio of IgE-bearing cells to total inflammatory cells was significantly elevated. These findings show that local IgE synthesis is highest in the gingiva of young patients with periodontitis and supports the concept that a hypersensitivity reaction mediated by IgE may play a role in periodontitis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1987.tb01601.x
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