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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 619-626 
    ISSN: 1432-1440
    Keywords: Non-Hodgkin's lymphoma high grade malignancy ; Anaplastic centrocytoma ; Kiel classification ; Symptomatology ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An analysis of 173 cases of non-Hodgkin's lymphoma (NHL) admitted to our hospital from January 1973 to January 1983 is presented. Of the 173 cases, 124 patients suffered from NHL of high grade malignancy according to the Kiel classification (37 centroblastic lymphoma (CB), 30 immunoblastic lymphoma (IB), 43 lymphoblastic lymphoma (LB), 14 NHL high grade malignancy unclassifiable). In addition, 26 patients with secondary high grade malignant NHL were included in the analysis (14 secondary CB, 10 secondary IB, 2 secondary LB). Also investigated were 23 patients with anaplastic centrocytic lymphoma (CC) (20 primary CC, 3 secondary CC), an entity originally classified as low grade malignant lymphoma, but showing a poor outcome and need for aggressive therapy. Symptoms at presentation of all patients are described. Of the 173 patients, 71% had an advanced stage of the disease at the time of diagnosis (Ann Arbor stage III or IV). B-symptoms were observed in 81%. Extranodal involvement, (exceptive bone marrow involvement), determined by clinical examination was seen in 55%. Survival of patients changed significantly after replacing initial radiotherapy with aggressive chemotherapy (P〈0.001). Improvement of survival statistics was due to the better outcome of patients with localized stages (Ann Arbor stages I and II) as compared to those with generalized disease (P〈0.002). Prognostic factors influencing survival were elevation of lactic dehydrogenase (P〈0.0001) and response to therapy (P〈0.0001). Histological subtypes according to the Kiel classification also showed prognostic relevance. The outcome of patients was significantly influenced by the therapeutic modalities administered.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 489 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0584
    Keywords: CHOP-Chemotherapy-first line treatment ; Kiel-classification ; unfavorable prognosis NHL ; prognostic factors ; risk factor score
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 58 NHL-patients (9 large cell centrocytic, 18 centroblastic, 16 immunoblastic, 15 lymphoblastic lymphomas) were treated immediately after diagnosis with CHOP-chemotherapy regardless of the extent of disease. Because of the advanced age of the majority of patients (median age 61 years, range 22–85 years) a reduced dose in the first two cycles was administered. Statistically significant prognostic variables influencing survival were the following: histologic subtypes according to the Kiel-classification (p〈0,05), B-symptoms (p〈0,001), blood sedimentation rate (p〈0,02) and LDH (p〈0,0005). With regard to prognosis there was no difference between patients over 60 years of age and younger ones (p〈0,4). Patients achieving complete remission survived significantly longer (p〈0,0001). Ann Arbor stages were of limited value, since patients with CS II disease and accumulation of risk factors (B-symptoms, abdominal disease, bulky tumor masses) showed a poorer outcome than patients with CS III who did not have these risk factors. A risk factor score summarizing features influencing prognosis is described and might be a useful tool in stratifying the heterogenous group of NHL with unfavorable prognosis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 374 (1989), S. 95-98 
    ISSN: 1435-2451
    Keywords: Chronic, idiopathic, thrombocytopenic purpura ; Splenectomy ; Cortison-non-responder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Zeitraum von 1978 bis 1987 unterzogen sich 11 Männer und 16 Frauen mit einem Altersmedian von 35 Jahren (14 Jahre bis 85 Jahre) einer therapeutischen Splenektomie wegen chronisch-idiopathischer, thrombocytopenischer Purpura. Kein Patient verstarb postoperativ im Rahmen des stationären Aufenthaltes. 77,8 (21 Patienten) verblieben in einer dauerhaften Remission. Nur 6 Patienten - davon 4 Cortison-NonResponder - rezidivierten und benötigten weiterhin konservative Therapie.
    Notes: Summary In the period between 1978 to 1987 16 female and 11 male patients with a median age of 35 years (range: 14 years to 85 years) underwent splenectomy for ITP. There was no lethality in the postoperative period. 77.8% of all patients are in a complete remission, only 22.2% showed a recurrence and need further conservative therapy.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Kinematics predicts the severe suppression of low-energy (〈1 GeV) secondary antiprotons in the Galactic cosmic rays. Thus the observation several years ago of a finite flux of low-energy antiprotons could not be explained with existing models of cosmic ray propagation, which led to a plethora of theoretical speculation. We have recently flown a balloon-borne instrument to measure the energy spectrum of cosmic-ray $$\bar p's$$ , and have found no antiprotons in the energy interval 200–640 MeV (corrected to the top of the atmosphere). This yields an upper limit to the $$\bar p/p$$ ratio of 5.5×10−5 (90% confidence level), well below and hence contradicting the earlier result.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 19 (1988), S. 289-294 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Test Methods and Dimensioning of Tribologically Loaded PartsOwing to the complexity of tribological systems the testing of wear components is of particular significance. Here is an effort to show the advantages and disadvantages of product tests, component tests and model tests. Even with model tests good results for the products are attainable when relevant parameters are systematically varied. Hereto some examples are given.
    Notes: Wegen der Komplexität tribologischer Systeme ist die Prüfung verschleißbeanspruchter Bauteile von besonderer Bedeutung. Es werden die Vor- und Nachteile der Erzeugnisprüfung, der Bauteilprüfung und der Modellprüfung aufgezeigt. Auch mit Modellprüfungen kann man für die Praxis gute Ergebnisse erzielen, wenn man relevante Parameter systematisch variiert. Hierzu werden einige Beispiele gezeigt.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 20 (1989), S. 14-20 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Fretting Wear The characteristic feature of fretting wear compared with other types of wear lies in the intensive interactions between transfer of debris, mode of vibration and wear. In particular, the forms of wear are heavily dependent on the continued presence or removal of the resulting wear particles and on the accessibility to lubricants. The systematic treatment of the individual forms of wear facilitates the analysis in cases of damage. Despite the system dependence of wear, the methods of the test chain and of parameter variation makes it possible to achieve practical test results also with component and model tests. An example shows how the quality of tribologically stressed components can be systematically improved in this way.
    Notes: Das charakteristische Merkmal der Verschleißart Schwingungsverschleiß gegenüber anderen Verschleißarten ist die intensive Wechselwirkung zwischen Stofftransport, Schwingungsform und Verschleiß. Insbesondere die Verschleißerscheinungsformen werden stark vom Verbleib oder Abtransport der entstehenden Verschleißpartikel und den Schmierstoffzutrittmöglichkeiten beeinflußt. Eine systematische Behandlung der einzelnen Verschleißerscheinungsformen erleichtert die Analyse von Schadensfällen. Trotz der Systemabhängigkeit des Verschleißes bieten die Methoden der Prüfkette und der Variation der Parameter die Möglichkeit, auch mit Bauteil- und Modelltests praxisnahe Prüfergebnisse zu erzielen. In einem Beispiel wird gezeigt, wie man damit die Qualität tribologisch beanspruchter Bauteile systematisch erhöhen kann.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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