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  • 1
    ISSN: 1432-0533
    Keywords: Immunohistochemistry ; Medulloepithelioma ; Cytoskeletal proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four examples of human cerebral medulloepithelioma were studied immunohistochemically with a panel of antibodies and antisera to neuronal and glial proteins. The tumors, in addition to primitive medullary epithelium, contained areas of neuroblastic, ganglionic, astrocytic, ependymoblastic and ependymal differentiation, and, in one tumor, areas resembling polar spongioblastoma. Tumor cells throughout the primitive medullary epithelium displayed focal immunocreactivity for vimentin, glial fibrillary acidic (GFA) protein and for the neuron-associated class III β-tubulin isotype. Neuroblasts showed immunoreactivity for the class III β-tubulin isotype, microtubule-associated protein 2 and neuron-specific enolase. Immunoreactivity for neurofilament epitopes and synaptophysin was detected in areas of ganglionic differentiation and coincided with the demonstration of neurofibrils in Bielschowsky's silver impregnations. Vimentin was the only marker detected in ependymoblastic and ependymal rosettes or in areas of polar spongioblastoma, as well as in mesenchymal, cells. The results indicate that, even in very primitive neoplastic neuroepithelium, immunocytochemical evidence of early commitment of some of the cells to a neuronal or glial lineage can be demonstrated. The neuron-associated class III β-tubulin isotype appears to be one of the earliest markers indicative of neuronal differentiation in normal and neoplastic primitive neuroepithelium.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 78 (1989), S. 472-483 
    ISSN: 1432-0533
    Keywords: Astroblastoma ; Electron microscopy ; Immunohistochemistry ; Organ culture ; Tanycytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two examples of cerebral astroblastoma have been studied by electron microscopy and immunohistochemistry, one of them having been maintained in vitro in an organ-culture matrix system for 8 months and the explants studied by light and electron microscopy at different time intervals. The fine structural characteristics were those of a glial cell type with features intermediary between those of astrocytes and ependymocytes. They recapitulated the structure of the tanycyte, a glial precursor cell which is normally found scattered along the ependymal lining of the embryonal and neonatal mammalian brain, but is distinct from epithelial ependymocytes. The possible origin of some astroblastomas from such a cell would account for a number of characteristics in this enigmatic type of glioma.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0533
    Keywords: S-Antigen ; Monoclonal antibody ; Pineal gland ; Pineocytoma ; Pineoblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 2671-2694 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This article presents a review of the state of the art of research and development on Hg1−xCdxTe -Hg1−yCdyTe (0≤x,y≤1) heterostructures important for applications in the modern infrared detection technique. It deals with the fundamental physical properties, epitaxial growth methods, and applications of these structures. The most important experimental results relevant to this subject are described and discussed. Following a short survey of the physical properties of Hg1−xCdxTe, the travelling heater method for growing bulk crystals of Hg1−xCdxTe has been described and compared with the epitaxial growth techniques used to prepare thin films and layered structures of this compound. Some important aspects of substrate preparation procedures related to CdTe wafers have been discussed. Then the most important problems regarding the liquid-phase, vapor-phase, and molecular-beam-epitaxy methods of Hg1−xCdxTe -Hg1−yCdyTe (0≤x,y≤1) heterostructures have been studied. A comprehensive discussion of technology and the parameters of different heterostructure photodiodes made of Hg1−xCdxTe with electrically passive and electrically active heterointerfaces has been presented. The review is concluded with an overview of research problems relevant to HgTe-CdTe superlattices and the surfaces and heterointerfaces of Hg1−xCdxTe.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 1396-1398 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Thermal desorption experiments concerning Te deposits on GaAs (100) surfaces have been performed using quadrupole mass spectrometry. The results give evidence that near the GaAs surface two regions of different Te adsorption can be distinguished. The first region nearest to the substrate surface consists of Te adparticles, which are chemisorbed to the substrate reevaporating at temperatures above 510–520 °C. The adparticles of the second physisorbed region begin to desorb at 350–360 °C, which is still considerably higher than the desorption temperature of the bulk Te deposits. The approximate thicknesses of these two regions are 1–2 monolayers and 3–10 monolayers of Te, respectively.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Serotonin ; Receptor hypersensitivity ; Anxiety ; Cortisol ; Panic disorder ; MCPP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0630
    Keywords: 68.55 ; 81.10 ; 85.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract A simple selection rule for epitaxial growth techniques, which is based on morphological stability of the substrate surface is proposed. According to this rule a certain growth technique should be used for preparing a specific device structure of a three-dimensional monolithically integrated optical or electronic circuit. The formulae for morphological stability functions for LPE, MO, VPE, and MBE growth techniques are given. Calculations performed for the GaAs/Al x Ga1−x As material system by using the linear morphological stability theory of Mullins and Sekerka suggest that from the point of view of morphological stability the most suitable growth technique for fabrication of three-dimensional monolithically integrated optical and electronic device structures is the MBE technique.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Transverse energy distributions have been measured for collisions of 10 GeV/nucleon Si with targets of Al, Cu and Pb using a combination of a NaI wall and a uranium based sampling calorimeter. The measured cross sectionsdσ/dE T anddE T /dη are consistent with full stopping and an increase, with increasing values ofE T , of energy flow into large angles.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 323 (1986), S. 91-96 
    ISSN: 1434-601X
    Keywords: 20.25.40 Fq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Cross sections of (n, p), (n, α), and (n, 2n) reactions on molybdenum isotopes have been measured, in the neutron energy range from 13 MeV to 17 MeV, and interpreted in terms of evaporation from the compound nucleus and preequilibrium emission.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cancer and metastasis reviews 5 (1987), S. 343-365 
    ISSN: 1573-7233
    Keywords: embryonal tumors ; central nervous system ; growth factors ; indoleamines ; receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While the embryonal central neuroepithelial tumors present complex conceptual and clinical problems, advances in cell type identification by special neurohistological, immunohisto- and immunocytochemical techniques have permitted discrimination of distinct cytomorphogenetic entities. These are based in part on their resemblance to the normal phases of neurocytogenesis. Four of these tumors, medulloepithelioma, desmoplastic infantile ganglioglioma, pineoblastoma and medulloblastoma, are designated as multipotential in light of their capacity to undergo divergent differentiation. Cytomorphogenetic, clinical and experimental data implicate fetal neural cell targets for transformation and raise the possibility that aberrant developmental regulatory mechanisms may contribute to the biologic behavior of these tumors. Growth factors and some neuroregulatory neurotransmitters (such as serotonin) are known to act as modulators of normal neuromorphogenesis. They could play a regulatory role in central neuroepithelial tumors on the hypothesis that the aberrant behavior of the embryonal neoplasms could either be modified by fuctional receptor responses or result from abnormal receptor responses to these substances. Future challenges include 1) the definition of new cytomorphogenetic entities and subgroups of the currently defined forms of embryonal CNS tumors based on the presence of specific growth factors and neuroregulatory neurotransmitters, or their receptors, 2) the characterization of neoplastic receptor responses mediating any modulatory role of the presently known growth factors or neuroregulatory neurotransmitters on the growth and maturation potential of the embryonal central neuroepithelial tumors and 3) the further definition of developmental, stage-specific modulators that might be operative in these tumors.
    Type of Medium: Electronic Resource
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