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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 431-436 
    Details
    ISSN: 1420-9071
    Keywords: CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940539
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of the bile-acid sequestrant colestipol on postprandial serum bile-acid concentration: evaluation by bioluminescent enzymic analysis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 3 (1989), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chronic ingestion of bile-acid sequestrants has been shown to decrease the serum cholesterol concentration and coronary events in hypercholesterolaemic patients. To develop improved sequestrants, a rapid, convenient method for testing the bile-acid binding efficacy of sequestrants is needed. Serum bile-acid concentrations could be used to detect bile-acid binding by an administered sequestrant, since the serum bile-acid concentration is determined largely by the rate of intestinal absorption in healthy individuals. To test this, serum bile-acid concentrations were measured at frequent intervals over 24 h in five otherwise healthy hypercholesterolaemic subjects during the ingestion of three standard meals, with or without the addition of 5 g colestipol granules administered 30 min before each meal.Total serum bile-acid concentration was measured with a previously reported bioluminescent enzymic assay, that uses a 3α-hydroxysteroid dehydrogenase, an oxido-reductase, and a bacterial luciferase co-immobilized on to Sepharose beads. Bile acids in 1 ml of serum were isolated by solid-phase extraction chromatography with reversed-phase C18 cartridges.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1989.tb00189.x
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  • 3
    Electronic Resource
    Electronic Resource
    A Nd and Sr isotopic study of the Ivrea zone, Southern Alps, N-Italy (1987)
    Springer
    Contributions to mineralogy and petrology 97 (1987), S. 31-42 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ivrea zone represents a tilted cross section through deep continental crust. Sm-Nd isotopic data for peridotites from Baldissero and Balmuccia and for a suite of gabbros from the mafic formation adjacent to the Balmuccia peridotite provide evidence for an event of partial melting 607±19 Ma ago in an extended mantle source with ɛ 607 Nd =+0.4±0.3. The peridotites are interpreted as the corresponding melt residue, the lower part of the mafic formation as the complementary melts which underwent further differentiation immediately after extraction. The Finero body represents a complex with layers of phlogopite peridotite, hornblende peridotite, and amphibole-rich gabbro. The isotopic signatures fall into two groups: (1) highly radiogenic Nd and low-radiogenic Sr characterize the phlogopite-free, amphibole-rich rocks, whereas (2) low-radiogenic Nd and highly radiogenic Sr is found in ultramafics affected by “phlogopite metasomatism”. Phlogopite metasomatism in the Ivrea zone is dated by a Rb-Sr whole rock isochron yielding 293±13 Ma. It was fed by K-rich fluids which were probably derived from metasediments. The high initial ɛ 293 Nd value of about +7.5 for phlogopite-free samples indicates a high time-integrated Sm/Nd ratio in the Finero protolith 293 Ma ago. Sm-Nd analyses of metapelites from the paragneiss series yield Proterozoic “crustal residence ages” of 1.2 to 1.8 Ga. Internal Sm-Nd isochrons for three garnetiferous rocks show that closure of garnet at temperatures around 600° C or even lower occurred about 250 Ma ago.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375212
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  • 4
    Electronic Resource
    Electronic Resource
    Petrogenesis of the magmatic complex at Mount Ascutney, Vermont, USA (1988)
    Springer
    Contributions to mineralogy and petrology 98 (1988), S. 408-416 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ascutney Mountain complex of eastern Vermont, USA, is a composite epizonal pluton of genetically related gabbro to granite intrusives. Nd isotopic data are reported for mafic rocks, granites, and nearby country rock. The parental mafic magma producing the complex 122 m.y. ago had 87Sr/86Sr=0.7039, 143Nd/144Nd=0.512678 (ɛ Nd=+3.8) and δ 18O=6.1‰, indicating a mantle source with time-integrated lithophile element depletion. Uniform initial radiogenic isotope ratios for granites, which are undistinguishable from those for the most primitive gabbro, suggest that the granite magma evolved from the mafic magma without crustal contamination and that the increase in δ 18O, to about 7.8‰, is the result of fractional crystallization. Mafic rocks show a large range in initial 143Nd/144Nd ratio, from about 0.51267 to 0.51236 (ɛ Nd= +3.7 to −2.5), which is correlated with elevated 87Sr/86Sr ratios and δ 18O. These data substantiate the production of mafic lithologies by fractional crystallization of the parental magma accompanied by assimilation of up to about 50% crust. The local country rocks include gneiss and schist and assimilation involved representatives of both rock types. The isotopic and chemical relationships preclude derivation from a single batch of magma undergoing contamination and indicate that a large magma body at depth evolved largely by fractionation with batches of melt issued from this chamber being variably contaminated at higher levels or at the level of emplacement. The Precambrian gneisses of the Chester dome and overlying lower Paleozoic schists have essentially identical Nd isotope systematics which suggest a crustal formation age of about 1.6. b.y. The parental sediments for the schists were apparently derived from a protolith similar to the gneissic basement without appreciable Sm/Nd fractionation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372361
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  • 5
    Electronic Resource
    Electronic Resource
    Tissue taurine content and conjugated bile acid composition of rhesus monkey infants fed a human infant soy-protein formula with or without taurine supplementation for 3 months (1988)
    Springer
    Neurochemical research 13 (1988), S. 311-316 
    Details
    ISSN: 1573-6903
    Keywords: Bile acids ; human infant formula ; taurine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concentrations of taurine in a number of brain regions and in other tissues of rhesus morkeys fed a taurine-free human infant formula for 3 months are substantially lower than in similar monkeys fed the same formula supplemented with taurine. Activities of enzymes involved in taurine biosynthesis were not different in the two groups except for liver cysteinesulfinic acid decarboxylase, which was greater in the monkeys fed formula alone. There was no difference in the biliary bile acid composition, but the proportion of bile acids conjugated with taurine was significantly greater in the monkeys fed formula supplemented with taurine. These results indicate that the effects of a taurine-deficient diet on infant primates are widespread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00972479
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  • 6
    Electronic Resource
    Electronic Resource
    Isotopic constraints on the origin of ultramafic and mafic dikes in the Balmuccia peridotite (Ivrea Zone) (1988)
    Springer
    Contributions to mineralogy and petrology 100 (1988), S. 261-267 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Balmuccia peridotite massif in the central Ivrea Zone constitutes an upper mantle slice which has been tectonically emplaced into the crust. It represents the residue from partial melting of undepleted mantle material and varies in composition from lherzolite to harzburgite and subordinate dunite. Dikes of websterite and gabbroic pods within the peridotite can be subdivided into an older Crdiopside suite and a younger Al-augite suite. Nd isotopic data on whole rocks of these lithotypes in combination with independent observations suggest that the dikes formed during a Hercynian event about 270 Ma ago. The rocks of the Cr-diopside dikes, in particular, display isotopic signatures similar to those of the lherzolite and represent fractionates from partial melts derived from the lherzolite wall rock. The Sm-Nd data of the pyroxenites and gabbros of the Al-augite suite, in contrast, scatter widely and suggest that partial melting of lherzolite was triggered or at least accompanied by introduction of fluids and/or liquid phases. These fluids or liquids carried exotic isotopic components from elsewhere in the crust-mantle complex, and deposited them within the rocks by metasomatic reactions. Two distinct types of metasomatism must have operated not only within the Balmuccia body, but also in the complex of Finero: The first type of metasomatism introduced mantle-derived volatiles and is responsible for formation of amphibole. The other type has a crustal source and led to formation of phlogopite, which occurs mainly within mantle rocks of Finero, but occasionally, within the Balmuccia body also.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00379737
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  • 7
    Electronic Resource
    Electronic Resource
    Precambrian crustal components, plutonic associations, plate environment of the Hercynian Fold Belt of central Europe: Indications from a Nd and Sr isotopic study (1988)
    Springer
    Contributions to mineralogy and petrology 98 (1988), S. 129-138 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Apparent crustal residence ages indicated by Nd model age data for metamorphic rocks, sediments and granitoids of the Hercynian Fold Belt of Europe vary from 1.3 Ga to 3.0 Ga, but are mainly in the range 1.4–1.7 Ga. 2 Ga basement inliers have been documented previously in northern Spain and islands off northwestern France but, in addition to these, old (∼2–3 Ga) model ages are found along the southern margin of the fold belt. These do not identify old inliers but are interpreted to represent Archeanearly Proterozoic crustal components recycled from a southern source. The Nd data, when considered together with the surface geology and recent single-grain zircon ion microprobe data, argue against a binary mixing of Archean components with new Palaeozoic crustal additions to generate the main 1.4–1.7 Ga model age population. Hercynian Europe comprise mainly recycled Proterozoic components although significant new Palaeozoic additions as well as Archean contributions are indicated. Nd and Sr isotopic data together with previous chemical and petrographic observations allow the recognition of a northern belt of continent margin I-type granitoids grading southwards to inner continent S-type plutons in the eastern half of the fold belt. This felsic plutonic association is used to infer a Hercynian plate configuration involving the attachment of the fold belt to a southern parent cratonic block that the model age data suggest may be of early Proterozoic-Archean age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402106
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  • 8
    Electronic Resource
    Electronic Resource
    Reorganization of the endoplasmic reticulum in epidermal cells of onion bulb scales after cold stress: Involvement of cytoskeletal elements (1989)
    Springer
    Planta 177 (1989), S. 273-280 
    Details
    ISSN: 1432-2048
    Keywords: Actin filament ; Allium ; Cold stress ; 3,3′-Dihexyloxacarbocyanine iodide ; Endoplasmic reticulum (reorganization) ; Microtubule ; Temperature (cold stress)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In the epidermal cells of onion (Allium cepa L.) bulb scales the endoplasmic reticulum (ER) can be subdivided into three domains: a peripheral tubular network, cisternae, and long tubular strands. The latter are the form in which the ER is moved in onion cells. During cold treatment the arrangement of the three domains changes drastically. The cisternae and long tubular strands disintegrate into short ER tubules which show rapid agitational motion. Long-distance movement is inhibited. The peripheral tubular ER network is presumably retained during cold treatment. Rewarming of previously chilled bulb scales initiates the reorganization of the ER into the three domains. The ER is partly relocated during recovery from cold treatment. Redistribution and reorganization of the ER is not affected by the microtubule-destabilizing herbicides oryzalin and trifluralin (5 μM). Cytochalasin D (2μM), however, inhibits not only the relocation of ER material, as is evident by the absence of long tubular ER strands, but also the movement of other cell organelles. The latter cluster on top of the cisternae in a manner which is characteristic of treatment with the actin-filament inhibitor. The array of actin filaments is similar in unstressed, cold-treated cells, and cells which recover from low temperatures in the presence of oryzalin or tap water alone. In the presence of cytochalasin D the actin filaments are severely fragmented. The results indicate that low temperatures most likely influence either the interaction of the force-generating system, probably myosin, with actin filaments, or the force-generating mechanism of the actomyosin-driven intracellular movement, but do not affect actin-filament integrity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00392816
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  • 9
    Electronic Resource
    Electronic Resource
    228. Hat der histologische Typ nach Lauren für die Planung des operativen Vorgehens zur kurativen Behandlung eines Magencarcinoms eine Bedeutung? (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 867-868 
    Details
    ISSN: 1435-2451
    Keywords: Stomach Cancer ; Lauren classification ; Prognosis ; Recurrence ; Magencarcinom ; Lauren-Klassifikation ; Prognose ; Rezidiv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beim Intestinalzelltyp unterscheidet sich die Rezidivrate bei einem Sicherheitsabstand von unter 20 mm (20,5%) nicht von einer Distanz über 20 mm (13,0%). Beim diffusen Typ kann eine Vergrösserung des Abstandes auf über 40 mm, die Rate von 26,5 auf 15,8% senken (n = 700, 1969–1985/31.12.86, RO). Bei Beachtung der Abstände nach oral und aboral beträgt für beide Typen die Rate eines lokalen Rezidivs 10%, die Prognose ist identisch (5-Jahresüberlebensrate bei diffusem/Intestinalzelltyp, pathologisches Stadium I 84,7/69,2%, II 62,6/65,9%, III 36,2/34,7%). Die Sicherheitsabstände sind besonders wichtig im Bereich von Oesophagus und Duodenum.
    Notes: Summary For the intestinal cell type of stomach cancer according to Lauren's classification, the local recurrence rate does not vary with a safety margin above or below 20 mm. However, enlargement over 40 mm can reduce the rate of local recurrence from 26.5% to 15.8% for the diffuse type (n = 700). With respect to the safety margin in oral and aboral resection lines, the rate is the same for both types (10%) as is the prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298012
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of low-temperature electron irradiation on the transition temperature of YBa2Cu3O7−δ superconductors (1988)
    Springer
    The European physical journal 71 (1988), S. 37-42 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Measurements of the complex susceptibility χ=χ′−iχ″ of electron-irradiated YBa2Cu3O7−δ show a strong influence of the electron irradiation dose, Φ·t on the transition temperatureT c . For irradiation doses of Φ·t=2.2·1019 e−/cm2 we find a damage rate of ΔT c /Δ(Φ·t)=−1.6·10−19 K/(e−/cm2). It is assumed that the decrease ofT c is mainly a bulk effect due to the production of atomic defects like vacancies and interstitials in the Cu−O−Cu chains and in the basal planes of the unit cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310841
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