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  • 1
    Electronic Resource
    Electronic Resource
    Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid (1988)
    Springer
    European journal of pediatrics 148 (1988), S. 267-269 
    Details
    ISSN: 1432-1076
    Keywords: Valproic acid ; Hyperammonaemia ; Aminoacidaemia ; Mitochondrial dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum amino acid pattern, blood ammonia, and serum valproic acid (VPA) levels were estimated in 75 epileptic children with and without VPA therapy. The incidence of patients with hyperammonaemia (〉60 μmol/l) in patients treated with only VPA or with a combination of VPA and other antiepileptic drugs was 19% and 20% respectively. Hyperammonaemia was not observed in patients receiving other drugs. Elevated levels of serum glycine, alanine and serine were more common in epileptic patients treated with VPA alone and with VPA in combination with other drugs than in patients receiving other drugs. A significant positive correlation was found between the serum levels of glycine and alanine, of glycine and serine, and of serine and alanine. These findings may indicate a mitochondrial dysfunction caused by VPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441418
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16 (1987)
    Springer
    Human genetics 〈Berlin〉 76 (1987), S. 20-26 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mapping of human aldolase A (ALDOA) gene was performed by molecular hybridization techniques using a panel of human-mouse cell hybrids and sorted fractions of human metaphase chromosomes besides in situ hybridization. For the purpose, three kinds of DNA probes derived from the coding region (probe-1), the 3′ noncoding region (probe-2), and the coding and 3′ noncoding regions (probe-3) of human aldolase A cDNA clone, pHAAL116-3, were selectively employed. The results of RNA and DNA blot analyses indicated that the human ALDOA gene is located on chromosome 16. The in situ hybridization experiment also indicated that the ALDOA gene was localized to 16q22–q24.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283044
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution of tetrodotoxin in various organs of the starfish Astropecten polyacanthus (1987)
    Springer
    Marine biology 96 (1987), S. 385-390 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tissues of various organs of the starfish Astropecten polyacanthus collected in the Hiroshima Prefecture from April 1985 to June 1986 were analyzed for lethal potency by the assay method for tetrodotoxin. The ovary showed the highest potency (47 to 1 450 MU g-1), followed by the digestive organs (〈10 to 960 MU g-1) and the exoskeleton including spines and tube-feet (〈10 to 170 MU g-1). The pyloric caecum and testis were less toxic. Overall toxicity was remarkably higher in females (2 060±382 MU, mean±SE) than in males (1 106±214 MU).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412522
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  • 4
    Electronic Resource
    Electronic Resource
    On the adhesion between Hydroxyl-Terminated Polybutadiene Fuel-Binder and Ammonium Perchlorate. Performance of bonding agents (1985)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 10 (1985), S. 176-180 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A simple method to evaluate the adhesive force between solid oxidizer and polymeric fuel-binder is presented. As an illustration, hydroxyl-terminated polybutadiene (HTPB) sticks including several different bonding agents are bonded on ammonium perchlorate (AP) single crystals, and stress-strain history until rupture occurs is obtained by applying uniaxial tensile stress perpendicularly to the adhesion surface. Further, whether each bonding agent reacts with AP or not was analysed with pursuing infrared absorption spectra. The hypothesis that the interfacial adhesive force arises from hydrogen bonding force is proposed.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19850100604
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    Paper (German National Licenses)
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