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  • 1
    Electronic Resource
    Electronic Resource
    Codon-induced association of the isolated anticodon loop of tRNAPhe (1986)
    s.l. : American Chemical Society
    Biochemistry 25 (1986), S. 6372-6378 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00369a005
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of mistletoe (Viscum album L.) extracts on cultured tumor cells (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 594-599 
    Details
    ISSN: 1420-9071
    Keywords: Mistletoe extract ; cytotoxic substances ; hepatoma tissue culture ; human leukemia cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Bacterially fermented mistletoe preparations (BFMP) were tested on rat hepatoma tissue culture (HTC) cells and human leukemia Molt 4 cells. A dose-dependent inhibition of the growth rate of the cells was observed. For both cell lines, cytostatic concentrations, expressed in weight of fresh plant, were 0.5 mg/ml culture medium for oak BFMP and 1 mg/ml for apple tree BFMP. However, the action of the two preparations was markedly different on each cell line. Non-viable HTC cells were not stained by trypan blue while non-viable Molt 4 cells were fully colored by this reagent. A lysis of cellular membranes of HTC cells was observed by electron microscopy. Furthermore, oak BFMP inhibited the growth of virus transformed 3T3-SV40 cells more than that of non-transformed 3T3 cells. In contrast to BFMP, non-fermented extracts and a purified mistletoe lectin showed a greater inhibition of the growth of Molt 4 cells than of HTC cells. Samples withdrawn at different times during fermentation gradually lost their inhibitory effect on the growth of Molt 4 cells while their action on HTC cells increased up to the 4th day of fermentation. These results are discussed in relation to the cytotoxic substances of mistletoe already characterized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955552
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  • 3
    Electronic Resource
    Electronic Resource
    Hypothermia in Hodgkin's disease after exploratory laparotomy (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 552-555 
    Details
    ISSN: 1432-1440
    Keywords: Hodgkin's disease ; Hypothermia ; Exploratory laparotomy ; Corticosteroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypothermia is a rare complication of unknown origin in Hodgkin's disease which has been reported after the administration of antineoplastic agents, chlorpromazine and paracetamol. We report a highly febrile patient with stage IV-B Hodgkin's disease of mixed cellularity type who underwent exploratory laparotomy. Because of suspected septic shock high-dose prednisolone was given during surgery. Postoperatively the patient's body temperature fell progressively to 32.9° C and remained at less then 35.5° C for the following 5 days. There seems to be some functional disorder of thermoregulation in Hodgkin's disease. Physical factors during surgery or certain drugs, especially cytotoxics, corticosteroids, anesthetics or antipyretics may lead to prolonged hypothermia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736525
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  • 4
    Electronic Resource
    Electronic Resource
    Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis (1986)
    Springer
    Archives of dermatological research 279 (1986), S. 89-94 
    Details
    ISSN: 1432-069X
    Keywords: Autologous T cells ; Epidermis cells ; Proliferation ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clinically uninvolved skin in psoriasis (autologous mixed epidermal cell lymphocyte reaction, AMECLR). Age- and sex-matched individuals served as controls. We found that the AMLR in psoriasis (n=11) was similar to that in healthy controls (n=16); furthermore, cell proliferation was alike in the presence of either 5% AB-serum or autologous serum. By contrast, while the AMECLR in healthy controls (n=9) resembled that in psoriatics employing epidermal cells from univolved skin, epidermal cells from lesional sites (n=10) induced a significantly higher proliferation of autologous T cells in the AMECLR (P〈0.01). We conclude that the in vitro stimulation of T cells by non-T mononuclear leukocytes is normal in psoriasis and is not regulated by autologous serum. Lesional psoriatic epidermal cells, however, are more active in stimulating autologous T cell proliferation than cells from univolved psoriatic or normal epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417528
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and biological properties of .alpha.-mono and .alpha.-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan (1988)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 31 (1988), S. 30-36 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00396a007
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  • 6
    Electronic Resource
    Electronic Resource
    Hämorheologie und Akute Phase Reaktion nach Thrombendarteriektomie der extracraniellen Arteria carotis (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 379-384 
    Details
    ISSN: 1432-1440
    Keywords: Hemorheology ; Acute Phase Proteins ; Vascular Surgery ; Carotid Arteries ; Arterial Occlusive Diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 39 patients with hemodynamically significant stenoses of the internal carotid artery thrombendarterectomy was performed. Hemorheological properties and plasma protein levels were studied pre- and postoperatively over a period of 14 days. In comparison to age-matched healthy controls preoperative plasma viscosity, red cell aggregation, fibrinogen, haptoglobin and alpha-1-antitrypsin were significantly elevated. After surgical trauma there was an increase in fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin, whereas alpha-2-macroglobulin, immunglobulin A and immunglobulin G decreased significantly. Plasma viscosity, red cell aggregation, red cell filterability, fibronectin and immunglobulin M remained unchanged. We conclude that our patients showed a non specific chronic “hematological stress syndrome” with raised acute phase reactants and corresponding hemorheological changes preoperatively; despite postoperative acute phase reaction no further deterioration of the rheological parameters could be observed; this might be caused by a decrease of plasma proteins with high frictional ratios compensating the increase of acute phase proteins. Besides, tissue damage and consecutive acute phase reaction in carotid arterial surgery seem to be of relatively minor degree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737940
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  • 7
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of muscarinic agonists (1987)
    Springer
    Psychopharmacology 93 (1987), S. 139-145 
    Details
    ISSN: 1432-2072
    Keywords: Arecoline ; Pilocarpine ; Oxotremorine ; Acetylcholine ; Muscarinic agonist ; Drug discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a two-lever, food-reinforced drug-discrimination paradigm separate groups of rats were trained to discriminate either arecoline, pilocarpine or oxotremorine from saline. The discriminative cues of all three agonists were potently blocked by scopolamine, but only by 30–60 fold higher doses of methylscopolamine. The three agonists all suppressed overall response rate. These rate-suppressant effects were not blocked by scopolamine in doses which blocked the discriminative cues. In generalization tests, arecoline elicited selection of the drug-appropriate lever in all groups of trained animals. Pilocarpine was discriminated as drug by all pilocarpine-trained animals and by a majority of oxotremorine-trained animals, but was not significantly discriminated by the arecoline-trained group. Oxotremorine was discriminated by all oxotremorine-trained animals but only by some pilocarpine-trained animals, and was not significantly discriminated by the arecoline-trained group. Morphine, haloperidol, chlordiazepoxide, pentobarbital and nicotine were not generalized to any of the training drugs. The discriminative stimuli produced by the training drugs are therefore specific and exhibit properties indicative of an origin at central muscarinic receptors but may not be identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179923
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of the scopolamine stimulus in rats (1988)
    Springer
    Psychopharmacology 95 (1988), S. 195-199 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Scopolamine cue ; Muscarinic agonists ; Muscarinic antagonists ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The discriminative stimulus properties of scopolamine, a potent antagonist at muscarinic receptors, were used for testing the discriminative effects of drugs known to act on cholinergic transmission. Rats were trained in a standard two-bar operant conditioning procedure with food as the reinforcer, according to a FR10 schedule. The training dose of scopolamine was progressively reduced from 0.25 mg/kg SC to the low dose of 0.062 mg/kg SC. Scopolarmine yielded an accurate discrimination in all the six rats tested. The generalization gradient resulted in an ED50 of 0.027 mg/kg. The scopolamine cue lasted for 1 h and was of central origin, since it was not mimicked by scopolamine methylbromide. The scopolamine stimulus generalized to atropine and trihexyphenidyl (respective ED50 values 2.20 and 0.21 mg/kg SC). Atropine depressed rate of responding, while trihexyphenidyl did not. Antagonism experiments with both direct agonists at the muscarinic receptor (arecoline and oxotremorine) and indirect agonists, i.e., inhibitors of the acetylcholine esterase [physostigmine and tetrahydroaminoacridine (THA)], led to inconsistent results. Increasing the doses of the agonists in order to block the scopolamine cue may be limited by their rate suppressant effect on responding. Based upon previously published results, it is suggested that the muscarinic agonist cue is more useful than the antagonist cue for investigating muscarinic transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174509
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacological characterization of the physostigmine stimulus in rats (1988)
    Springer
    Psychopharmacology 95 (1988), S. 553-555 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Physostigmine ; M1 receptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to discriminate 0.10 mg/kg SC physostigmine from saline in a two-lever food-reinforced task. There was generalization to the acetylcholine esterase inhibitor THA as well as to the muscarinic receptor agonists arecoline, oxotremorine and RS 86, but not to neostigmine or nicotine. The physostigmine cue was blocked by SC scopolamine hydrobromide and by ICV pirenzepine, but not by scopolamine methylbromide or by mecamylamine. These antagonism studies suggest that the discriminative cue elicited by physostigmine might be mainly mediated by central M1 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172975
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  • 10
    Electronic Resource
    Electronic Resource
    186. Gallengangs-Residualstein: endoskopische Sphincterotomie (EST) und Steinextraktion (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 840-840 
    Details
    ISSN: 1435-2451
    Keywords: Residual biliary concrement ; Endoscopie sphincterotomy (EST) ; Stone extraction ; Late results ; Residualstein ; Endoskopische Sphincterotomie ; Steinextraktion ; Langzeitergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 185 Patienten (8/74 bis 12/86) im Alter von 19–85 J. (Median 66 J.) wurde wegen Residualsteins bei noch liegendem T-Drain die EST vorgenommen. EST und Steinextraktion gelangen bei je 93%. Alle Komplikationen (9,3%) waren leicht und konservativ beherrschbar. Die Letalität nach EST war 0, nach offener 2. Revision 1,8%. 34% waren zur Zeit der EST unter 50 J. alt. Kontrollen 2,5 bis 9 J. nach EST ergaben Beschwerdefreiheit bei 95%, AP-Erhöhungen bei 7%, sonographisch Aerobilie bei 20%. Das Risiko der Spät-Cholangitis nach EST ist nach wie vor unbekannt. Beobachtungen über 3–4 Jahrzehnte und leberhistologische Befunde sind erforderlich.
    Notes: Summary In 185 patients (August 1974 to December 1986), aged 19–85 years (median 66 years), with indwelling T-tube drains, endoscopic sphincterotomy was performed for residual biliary concrements. EST and stone extraction both had a success rate of 93%. All complications (9.3%) responded to conservative therapy. Lethality was 0% for EST and 1.8% for open biliary revision. At the time of EST, 34% were under 50 years of age. Follow-up at an interval of 2.5–9 years after EST indicated no pain in 95%, elevated AP in 7%, and sonographic aerobilia in 20%. The risk of late cholangitis is still unknown. Follow-ups over a period of 4–5 decades and histological examination of liver biopsies are essential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297970
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