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  • 1
    Electronic Resource
    Electronic Resource
    Contact allergy to a cyclohexanone resin in humans and guinea pigs (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 18 (1988), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 5 patients with allergic contact dermatitis caused by various paints were demonstrated to be sensitive to a cyclohexanone resin (C-R) present in the paints. Sensitization studies in guinea pigs with C-R and cyclohexanone showed one batch of C-R to be a sensitizer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1988.tb05489.x
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  • 2
    Electronic Resource
    Electronic Resource
    Certain Human Gpl20-HIV Antibodies React with Anti-CD4 Antibodies (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 27 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: HIV+ human sera contain antibodies against most HIV proteins, including the envelope glycoprotein Gpl20. Some of these antibodies may have an epitope that sterically resembles the CD4 region to which the Gp120 molecule binds. Amongst 58 HIV+ sera tested, we found three with the capacity to block the binding of anti-CD4 monoclonal antibodies to CD4+ cells. The serum with the highest blocking capacity was selected for further analysis. The inhibitor was shown to be an antibody that binds to the Gp120 molecule as well us to the anti-CD4 monoclonal T4.2. These CD4-mimicking antibodies were shown not to interfere with CD4-dependent reactions in vitro. Virus neutralizing experiments in vitro could not show any neutralizing effect with these antibodies alone. The HIV+ individual providing this antibody is still healthy, although HIV since 1983.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb02328.x
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  • 3
    Electronic Resource
    Electronic Resource
    A Prospective Study of Immunoglobulin Changes in Relation to Human Immunodeficiency Virus Infection in a Cohort of Homosexual Men (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 29 (1989), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Changes in IgG levels and patterns in association with human immunodeficiency virus, (HIV) infection were characterized in a prospective investigation by studying serum electrophoresis and antibodies to HIV at least once a year in 144 homo/bisexual (HS) men during a 4-year period. Initially, 25 men (17.4%) were HIV-positive, and this increased to 44 at the end of the study period. HIV-negative men had IgG levels of 11.2 ± 2.2 g/l. In the 19 HIV seroconverters the mean IgG level rose with time according to the equation IgG = 0.054×+ 12.56 (x= months after the last HIV-negative test). Oligoclonal IgG bands were found in three of the 19 seroconverters (16%) prior to conversion and in 2/16 (13%), 5/13 (38%), 7/11 (64%), and 3/8 (38%) 1,2, 3, and 4 years after conversion, respectively. Of the 25 initially HIV-positive men, five have developed acquired immunodeficiency syndrome (AIDS) during the 4.5 year follow-up. At the first investigation these five men had higher mean IgG levels (16.0 ± 2.7 g/l) than the 20 men who have remained healthy (14.6 ± 2.8 g/l), and all live had oligoclonal bands as compared to 9/20 of those who did not develop AIDS. Oligoclonal IgG bands reflect the IgG increase and seem to indciate long-standing HIV infection and a poor prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1989.tb01162.x
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison among five mutagenicity assays in workers producing polyurethane foams (1988)
    Springer
    International archives of occupational and environmental health 60 (1988), S. 175-179 
    Details
    ISSN: 1432-1246
    Keywords: Isocyanates ; Amines ; Occupational exposure ; Cytogenetic testing ; Mutagenic assays
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-two male individuals exposed to isocyanates and amines during the production of plastic foams and 20 male referents were studied by cytogenetic methods (chromosomal aberrations, sister chromatid exchanges and micronuclei in lymphocytes) and by urinary mutagenic assays (thioether concentrations and mutagenic activity with Salmonella TA98 and E. Coli WP2 uvrA). The occupational exposure was monitored by measurements of toluene diisocyanate and N-methylmorpholine in work-room air. The levels were below the current Swedish hygienic standards. Although all parameters, except the sister chromatid exchanges, showed increased mean values for the exposed group compared to the referents, only the urinary thioether concentrations differed significantly. The study was, however, non-conclusive with regard to a genetic effect of the occupational exposure as measured by the cytogenetic parameters. This may be due to the low exposure level. In the micronuclei frequencies there was a significant effect of age. Smoking significantly affected the SCE frequencies, the thioether concentrations and the mutagenic activities in the Salmonella assay. There were statistically significant correlations between the urine specimens collected during one working day and the following morning with regard to the mutagenic activities in the Salmonella and E. coli assays, and in the thioether concentrations as well. The association between the different cytogenetic and urinary mutagenic assays were weak but there were several statistically significant correlation coefficients, indicating that the variables may have a common metabolic background.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378694
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  • 5
    Electronic Resource
    Electronic Resource
    Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children (1989)
    Springer
    Diabetologia 32 (1989), S. 387-395 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; islet cell antibodies ; thyroid peroxidase antibodies ; thyroglobulin antibodies ; H+, K+-ATPase antibodies ; case-control study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with the disease. Nearly all (389/405, 96%) children (0–14 years) in Sweden, who developed diabetes during one year, were therefore studied to compare islet cell, thyroid peroxidase, thyroglobulin, and gastric H+, K+-ATPase antibodies with 321 age, sex, and geographically matched, but non-related, control children. Islet cell (cytoplasmic) antibodies were found in 81% (316/389) of the patients and in 3% (9/321) of the control children (p〈0.001). The median islet cell antibody levels were 70 (range 3–8200) Juvenile Diabetes Foundation (JDF) Units in the islet cell antibody positive patients, and 27 (range 17–1200) JDF Units in the control children (NS). Autoantibodies against thyroid peroxidase (8%), thyroglobulin (6%), and gastric H+, K+- ATPase (3%) were all increased in the patients compared with the control children, being 2% (p〈0.001), 2% (p〈0.01), and 0.3% (p〈0.01), respectively. During an observation time of 20–34 months, two of the nine islet cell antibody positive control children developed Type 1 diabetes, after 8 and 25 months respectively, while the others remained healthy and became islet cell antibody negative. None of the islet cell antibody negative control children developed diabetes during the same time of observation. This first investigation of an unselected population of diabetic children and matched control children shows: that islet cell antibodies are strongly associated with newly diagnosed childhood diabetes, that other autoantibodies are more frequent among diabetic children than control children, and that the frequency of islet cell antibodies in the background population of children is higher than previously documented, and could also be transient, underlining that factors additional to islet cell antibodies are necessary for the later development of Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277264
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  • 6
    Electronic Resource
    Electronic Resource
    Vibrational spectra, phase transitions and conformers of 1,4-dichlorobut-2-yne (1987)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 18 (1987), S. 461-471 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman and IR spectra of 1,4-dichlorobut-2-yne (DCB) as a liquid at various temperatures and as an amorphous and as metastable and stable crystalline solids at low temperatures have been recorded in the 4000-20 cm-1 range. Additional IR and Raman spectra of a high-pressure crystalline phase were obtained at ca 17 kbar pressure.The broad unsymmetrical bands of DCB in the liquid and in the amorphous solid below 500 cm-1 suggest nearly free rotation in these phases at all of the temperatures investigated. Below ca 190 K a crystal containing the anti and above 190 K a crystal containing the gauche conformer of DCB were formed; the latter crystal is believed to be thermodynamically more stable at all temperatures. Only one high-pressure crystal with molecules in the anti conformation was formed at room temperature. A phase transition reported at 232 K in the liquid, involving a conversion to an anti conformer, was not detected.Complete vibrational assignments for both anti and gauche conformers are presented, supported by force constant calculations.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250180703
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