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  • 1
    Electronic Resource
    Electronic Resource
    Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions (1985)
    Springer
    Inflammation research 16 (1985), S. 76-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983105
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine metabolism after adverse reactions due to d-tubocurarine administration (1987)
    Springer
    Inflammation research 21 (1987), S. 54-61 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated histamine release in five female patients, submitted for gynaecological surgery, after intravenous administration of the neuromuscular blocking agent d-tubocurarine. In these patients we measured the plasma levels of histamine and its metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, making use of mass fragmentographic methods. The newly developed determination of plasma Nτ-methylimidazoleacetic acid had a within-day coefficient of variation of 2.7% (n=10). Normal values of Nτ-methylimidazoleacetic acid in plasma ranged from 41.3–75.6 nmol/l (n=13). All five patients developed anaphylactoid reactions: two patients showed severe systemic reactions, one patient a minor systemic reaction and two had skin reactions only. Plasma histamine and Nτ-methylhistamine levels appeared to be the most reliable biochemical parameters for confirming both the occurrence and severity of an anaphylactoid reaction. In comparison with plasma histamine, the determination of plasma Nτ-methylhistamine is less hampered by artefacts caused by blood collection and plasma preparation. Together with the fact that the increase in plasma Nτ-methylhistamine levels after anaphylactoid reactions lasts much longer than the increase in plasma histamine levels, this leads to the conclusion that the determination of plasma Nτ-methylhistamine is a useful retrospective parameter for histamine release in this type of pathological state. The plasma Nτ-methylimidazoleacetic acid levels fluctuated considerably, showing only a significant increase after administration of d-tubocurarine in the two patients who had severe anaphylactoid reactions. This parameter is, therefore, less useful in such studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974921
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: Influence of histamine-rich food (1989)
    Springer
    Inflammation research 27 (1989), S. 205-207 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, we have determined and correlated the excretion of the 2 most important histamine metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, in 24-hour urine and morning urine samples of 14 normal healthy persons. We found no significant difference between morning urine and 24-hour urine samples, provided that the subjects were on a histamine-poor diet for at least 24 hours. We also studied the influence of the consumption of histamine-rich foodstuffs on the reliability of these parameters. The morning urinary Nτ-methylhistamine excretion is less affected by histamine-rich foodstuffs and therefore proposed to be the most reliable parameter for endogeneous histamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222240
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  • 4
    Electronic Resource
    Electronic Resource
    Histamine in late asthmatic reactions following house-dust mite inhalation (1985)
    Springer
    Inflammation research 16 (1985), S. 252-255 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the role of histamine in the late asthmatic reaction (LAR) following house-dust mite (HDM) inhalation, we studied, with hourly intervals, urinaryN τ-methylhistamine (an important metabolite of histamine) in 14 allergic asthmatic patients before and after broncho provocation with HDM. Four patients showed an early asthmatic reaction (EAR), while 10 patients developed a LAR as well. In the hour following the EAR a significant increase in urinaryN τ-methylhistamine was observed as compared to the control day (0.01〈p〈0.05). During the LAR no increase of this metabolite was detected in the urine of the patients. Additionally, histamine was measured in broncho alveolar lavage fluid (BAF) obtained from 6 patients during the HDM-provoked LAR and compared to histamine levels in BAF from patients without a LAR, following broncho provocation. In the LAR group higher histamine levels were found than in the other patient and control groups. For the whole patient group no correlation was found between the degree of bronchial obstruction during the LAR and the BAF histamine values. No difference was found inN τ-methylhistamine in BAF between patients with LAR and controls. Thus histamine metabolite studies in the urine failed to provide evidence of involvement of histamine in the LAR, while further data are needed to interpret the results of local sampling in the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983153
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of isoprenaline and terbutaline on urinary excretion of histamine and its two main metabolites in systemic mastocytosis (1986)
    Springer
    Inflammation research 18 (1986), S. 269-272 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Both short-term and long-term effects of the β-sympathomimetic drugs isoprenaline and terbutaline on the urinary excretion of histamine and its two main metabolites were evaluated in patients with systemic mastocytosis. In a short-term study isoprenaline and terbutaline were given intravenously during five hours to three and two patients, respectively. Compared with placebo infusion Nt-methyl-histamine excretion fell during terbutaline administration, whereas during isoprenaline no changes were observed. In a long-term study three patients received a treatment with orally administered terbutaline for 24 days. In one patient a slight reduction of the excretion of the histamine metabolites was found. In another patient the excretion of histamine and its metabolites, decreased especially during the eight days observation period after the end of the treatment. In this study we saw occasionally large and rapid changes occurring simultaneously in all three urinary parameters of histamine release. In conclusion, terbutaline can reduce histamine release in systemic mastocytosis. However, because of the small symptomatic and biochemical effects found in our patients, the clinical significance of β-sympathomimetic drug treatment in this disease has yet to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01988039
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  • 6
    Electronic Resource
    Electronic Resource
    Age dependent normal values of histamine and histamine metabolites in human urine (1988)
    Springer
    Inflammation research 23 (1988), S. 307-310 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We collected morning urine samples from normal healthy persons, who had not yet breakfasted, in the age range of 2–61 years and measured urinary excretion of histamine and its metabolites Nτ-methylhistamine and Nτ-methylimidazoleacetic acid. The values obtained (expressed in terms of urinary creatinine excretion), were age dependent up to the age of 12. Thereafter, values stabilized and were no longer are dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02142572
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of oral slow-release terbutaline on early morning dyspnoea (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 159-162 
    Details
    ISSN: 1432-1041
    Keywords: terbutaline ; asthma ; slow-release formulation ; early morning dyspnoea ; side-effects ; serum terbutaline level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight male patients with partly reversible airflow obstruction, who had a diurnal variation in peak expiratory flow rate (PEFR) of more than 20% were treated with placebo and slow-release terbutaline tablets (5 mg at 08.00 hours and 10 mg at 20.00 hours) for 8 days. On Day 8 of each period, PEFR and serum terbutaline were measured at 4 and 2-h intervals, respectively. PEFR on the terbutaline day showed a significant increase at 08.00, 12.00, 24.00, 04.00 and 08.00 hours as compared to the placebo day. Slow-release terbutaline prevented early morning dyspnoea. The serum concentration was 3.3 ng/ml during the day and 3.5 ng/ml during the night. During terbutaline therapy the patients reported fewer complaints than during the placebo period. It was concluded that slow-release terbutaline tablets are suitable for twice daily treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609685
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