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  • 1
    Electronic Resource
    Electronic Resource
    Partial ornithine transcarbamylase deficiency in females: diagnosis by an immunohistochemical method (1987)
    Springer
    European journal of pediatrics 146 (1987), S. 370-372 
    Details
    ISSN: 1432-1076
    Keywords: Ornithine transcarbamylase deficiency ; Heterozygote ; Immunohistochemical analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Females heterozygous for the X-linked urea cycle disorder, ornithine transcarbamylase (OTC) deficiency have a significant risk of developing hyperammonaemia. Diagnosis of this genetic defect in a proband is the essential starting point for family studies. By an immunohistochemical analysis of the liver specimens fixed in 10% formalin, we confirmed heterozygous status for OTC deficiency in two female patients, a 15-year-old girl and a 2-year-old girl, who died of hyperammonaemia. Since most affected males lack cross reactive materials (CRM), an immunochemical analysis should be useful for the diagnosis of most heterozygous females.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444940
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  • 2
    Electronic Resource
    Electronic Resource
    Bonding mechanism between silicon carbide and thin foils of reactive metals (1985)
    Springer
    Journal of materials science 20 (1985), S. 3976-3982 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Pressureless-sintered SiC pieces and SiC single crystals were joined with foils of reactive metals at 1500° C (1773 K) for titanium and zirconium foils or at 1000° C (1273 K) for Al/Ti/Al foils. Bend testing at various temperatures up to 1400° C (1673 K), optical and electron microscopy, and electron-probe X-ray microanalysis studies were carried out on the specimens. From the results, it was concluded that the fairly high bond strength of titanium-foil joined SiC specimens might be attributed to the formation of a Ti3SiC2 compound, since good lattice matching between SiC and Ti3SiC2 was obtained in the SiC single crystals. Also in the Al/Ti/Al-foil joined SiC, high bond strength was obtained, but it decreased steeply at 600° C (873 K) because of a retained aluminium phase. The bond strength in the zirconium-foil joined SiC was low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00552387
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  • 3
    Electronic Resource
    Electronic Resource
    Time relationship between ambient temperature change and antigen stimulation on immune responses of mice (1989)
    Springer
    International journal of biometeorology 33 (1989), S. 19-23 
    Details
    ISSN: 1432-1254
    Keywords: Temperature change ; Immune response ; Male mice ; Corticosterone ; Physiological adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract We investigated the time relationship between ambient temperature change and antigen stimulation on immune responses to sheep red blood cells (SRBC) and polyvinylpyrrolidone (PVP) in mice. In the case of a shift from comfortable (25°C) to cold (8°C) temperatures, suppression in the number of splenic plaque-forming cells (PFC) took place mainly when the shift was done between 1 day before and 2 to 4 days after immunization. The suppression of the PVP response lasted for up to a maximum of 6 days when mice were transferred 1 day before immunization. In the case of a temperature shift from 25° to 36.5°C, the suppressive effect was found when the temperature shift was done between 4 days before and 2 days after immunization. The effect lasted longer than that of the temperature shift to cold, i.e., at least 9 days after the temperature shift. Blood corticosterone levels after the temperature shifts corresponded to changes in the immune responses: elevation of the blood corticosterone levels was observed for only the first 3 days after a temperature shift to 8°C but for 10 days after a temperature shift to 36.5°C during the period time of the experiment. These result suggested that blood corticosterone level contributes to the duration of the effects of temperature shifts on immune responses of mice. Furthermore, it appeared that the early stage of the immune response is more susceptible to temperature shifts than the later stage. To explain these results, the terms “effective period” in the course of physiological adaptation to changed ambient temperature and “susceptible period” in the course of the immune response, were proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01045892
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of the light-dark cycle and its inversion on the susceptibility of mice to lead acetate (1987)
    Springer
    International journal of biometeorology 31 (1987), S. 95-107 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract The effects of the light-dark (LD) cycle and its inversion on the susceptibility of mice to lead were investigated. Groups of mice were injected once with a high (200 mg Pb/kg body weight) or low (10 mg Pb/kg body weight) dose of lead acetate at one of four-hourly intervals, i.e., 09.00 h, 13.00 h, 17.00 h, 21.00 h, 01.00h, and 05.00 h, on the days before and after a phase shift in the LD cycle. The main indices used to measure the susceptibility of the mice were dying rate and percent mortality of ICR mice following injection together with the Pb concentration (Pb-B) and δ-aminolevulinic acid dehydratase (ALAD) activity in the blood. In the present study, we ascertained the following facts: (1) Dying rate (time to death following injection) and Pb-B exhibited a circadian rhythm with a peak initiated by injection in the dark period. (2) Injection with a low dose of lead within a few days after an LD inversion significantly decreased the level of ALAD activity and increased the Pb in the blood in comparison with control animals kept under a non-inverted LD cycle. Both the dying rate and the percent mortality following a high dose of lead, however, were hardly affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02202929
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  • 5
    Electronic Resource
    Electronic Resource
    Abstracts of the Twenty-Fourth Annual Meeting of the Japanese Society of Biometeorology, Tsukuba, 2–3 December, 1985 (1987)
    Springer
    International journal of biometeorology 31 (1987), S. 339-365 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02188946
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  • 6
    Electronic Resource
    Electronic Resource
    A new model of Type 2 (non-insulin-dependent) diabetes mellitus in spontaneously hypertensive rats: diabetes induced by neonatal streptozotocin treatment (1986)
    Springer
    Diabetologia 29 (1986), S. 808-811 
    Details
    ISSN: 1432-0428
    Keywords: Hypertension ; streptozotocin ; animal model ; spontaneously hypertensive rats ; Type 2 (non-insulin-dependent) diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to develop an animal model of Type 2 (non-insulin-dependent) diabetes with persistent hypertension. Male spontaneously hypertensive rats were treated with 25.0, 37.5, 50.0, 62.5 or 75.0 mg/kg of streptozotocin given intraperitoneally at 2 days of age and maintained for 12 weeks. In the rats which received 50.0 mg/kg or more streptozotocin, overt hyperglycaemia gradually and consistently developed following incomplete recovery from an initial hyperglycaemia. Compared to vehicle-treated controls, body weight gain in these animals did not differ for the first 8 weeks; thereafter, it was slightly but significantly (p 〈 0.05) reduced. The animals treated with 25.0 or 37.5 mg/kg streptozotocin developed mild to moderate hyperglycaemia, but their body weight gain was similar to controls. The relationships between streptozotocin dose and metabolic responses (plasma glucose, glycosylated haemoglobin, urinary glucose, food intake, etc.) were clearly demonstrated. Systolic blood pressure rose with progressing age in both controls and streptozotocin-treated rats, irrespective of dosage or metabolic response. This new rat model of Type 2 diabetes associated with persistent hypertension may be useful in studying these combined effects on small and large vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873221
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  • 7
    Electronic Resource
    Electronic Resource
    Application of the symbolic mathematics system to the finite element program (1989)
    Springer
    Computational mechanics 5 (1989), S. 41-47 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The stiffness matrix of a 4-nodes insoparametric element for the two dimensional finite element analysis is evaluated using the symbolic mathematics systems, called REDUCE. The results are compared with those obtained by numerical integration. It is shown that there exist some differences between the numerical values of the stiffness matrix by symbolic and numerical integrations. The differences become smaller as the integration points of the numerical integration increases, which means that the results obtained by symbolic integration give accurate values. The stiffness matrix in elastic-plastic state is also evaluated using symbolic mathematics, and it is shown that the results agree with those obtained by numerical integration. It is pointed out that there is a possibility to decrease the CPU time by using the symbolic mathematics system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01046878
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  • 8
    Electronic Resource
    Electronic Resource
    High pressure infrared spectra of diaplectic anorthite glass (1987)
    Springer
    Physics and chemistry of minerals 14 (1987), S. 345-349 
    Details
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract Samples of synthetic diaplectic anorthite glass (38 GPa shock pressure), thermal glass and synthetic anorthite crystals were investigated using infrared spectral methods at one atmosphere and high pressures (near 4 GPa). Band positions and pressure derivatives for the Si-O asymmetric modes in the region 1,300–900 cm−1 indicate that the diaplectic glass has more structural similarities with the crystalline material than with thermal glass even though the overall infrared spectral characteristics suggest a glassy state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309808
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  • 9
    Electronic Resource
    Electronic Resource
    Early development of nephropathy in a new model of spontaneously hypertensive rat with non-insulin-dependent diabetes mellitus (1988)
    Springer
    Diabetologia 31 (1988), S. 291-296 
    Details
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; hypertension ; nephropathy ; urinary protein ; streptozotocin ; N-acetyl-β-D-glucosaminidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We designed the present study to clarify whether the development of nephropathy was accelerated by a combination of hypertension and non-insulin-dependent diabetes. Spontaneously hypertensive rats with non-insulin-dependent diabetes induced by neonatal streptozotocin treatment (25.0–75.0 mg/kg) were separated into severely or mildly diabetic groups according to their non-fasting plasma glucose levels at 12 weeks of age and the findings were compared with the data on a control group treated with citrate buffer alone. The natural courses of urinary excretion rate of total protein, the molecular composition by sodium dodecyl sulfate polyacrylamide gel electrophoresis with laser desitometer and N-acetyl-β-D-glucosaminidase were measured in the three groups from 12 weeks until 36 weeks of age. Total urinary protein in the control group decreased with age (p〈0.05), while in the mildly diabetic group changes were nil; in the severely diabetic group, however, the excretion rates of total urinary protein and high molecular weight protein consistently and progressively increased with age (p〈0.05). The low molecular weight protein continuously decreased with age in the mildly diabetic and control groups (p〈0.05), while in the severely diabetic group there was no decrease after 28 weeks of age. The urinary N-acetyl-β-D-glucosaminidase markedly increased (p〈0.05) in the severely diabetic group throughout the period compared with findings in the control group, but drastically decreased (p〈0.05) in the mildly diabetic group with age. There were significant correlations between the mean glycosylated haemoglobin levels and all the urinary parameters measured (p〈0.05). These observations suggest that development of nephropathy is accelerated by the glycaemic level in hypertensive rats. This new model should be appropriate for studying the combined effects of hypertension and diabetes mellitus on the kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277410
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  • 10
    Electronic Resource
    Electronic Resource
    Raman microprobe study of synthetic diaplectic plagioclase feldspars (1989)
    Springer
    Physics and chemistry of minerals 16 (1989), S. 436-441 
    Details
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract Raman microprobe spectra were made on three post shock, diaplectic plagioclase feldspars. Optical and X-ray diffraction studies indicated that feldspars maintained a partially or totally crystalline state after having passed through the mixed phase zone of Hugoniot response to shock waves (15–38 GPa). The appearance of uniquely glass-type spectra occurs at different shock pressures for each specimen according to its atomic structural arrangement, below 38 GPa for mosaic structured labradorite, near 40 GPa for anorthite and above 50 GPa for the highly ordered low albite. The diaplectic anorthite and labradorite glasses give spectra which indicate the presence of two glass types. Shifts in the band envelope frequencies compared to spectra of fused glass and statically pressure densified glass suggest that these glasses have specific structural arrangements. These differences suggest that the shock and fusion glass-forming processes are not exactly identical. The results from material shocked in the mixed phase region of Hugoniot response show that the phase transitions are effected at different pressures depending upon the feldspar structural type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197013
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