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  • 1
    Electronic Resource
    Electronic Resource
    Prevention of rotavirus infection by oral administration of cow colostrum containing antihumanrotavirus antibody (1985)
    Springer
    Medical microbiology and immunology 174 (1985), S. 177-185 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After immunizing 8-month pregnant Holstein cows with human rotavirus, Wa strain, cow colostrum containing neutralizing antibody to human rotavirus, designated as Rota colostrum, was obtained. After randomly grouping 13 infants from a single orphanage, 6 infants received 20 ml of Rota colostrum every morning and 7 control infants received 20 ml of market milk. One month later, rotavirus associated diarrhea was observed in 6 of the 7 infants given milk and 1 out of the 6 infants given Rota colostrum. Orally administered Rota colostrum significantly protected infants from diarrhea caused by rotavirus (P 〈 0.05). Two out of 5 Rota colostrum recipients who were free from diarrhea showed rises in complement fixation (CF) antibody titer after the rotavirus infection epidemic. Thus, Rota colostrum prevented the outbreak of diarrhea but did not prevent immunological responses to natural rotavirus infection. In the therapeutic trial Rota colostrum had no effect on duration of diarrhea, bowel movements or virus shedding in stool. However, there were no side-effects of Rota colostrum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123694
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of hypertonic conditions on protein synthesis in MA104 cells infected with human rotavirus (1985)
    Springer
    Medical microbiology and immunology 174 (1985), S. 211-220 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When a high NaCl concentration was used to decrease selectively the synthesis of cell proteins, the synthesis of most cellular polypeptides was greatly diminished relative to human rotavirus proteins. Thus, in the presence of 150 mM excess NaCl, 11 viral polypeptides were clearly identified. However, hypertonic conditions also reduced viral protein synthesis to a different extent with individual proteins. No significant changes in viral protein synthesis occurred during incubation under the hypertonic condition for up to 6 h, and infectious virus yields of MA104 cells incubated in the hypertonic medium did not differ from the yields of untreated MA 104 cells. These results indicate that hypertonic conditions provide a useful tool for qualitative studies of viral protein synthesis in human rotavirus infected cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123698
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Successful transplantation of soy bean agglutinin-fractionated, histoincompatible, maternal marrow in a patient with severe combined immunodeficiency and BCG infection (1985)
    Springer
    European journal of pediatrics 143 (1985), S. 291-294 
    Details
    ISSN: 1432-1076
    Keywords: Severe combined immunodeficiency ; HLA-haplotype mismatched bone marrow transplantation ; Soy bean agglutinin ; BCG infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A successful transplantation of soybean agglutinin (SBA) and sheep red blood cell (SRBC)-fractionated, maternal marrow in a patient with severe combined immunodeficiency (SCID) is reported. The engraftment of HLA-haplotype mismatched marrow cells was obtained without apparent graft versus host disease (GVHD). With immunological reconstituion the patient recovered from a BCG infection, which might have been caused by a BCG inoculation before his bone marrow transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442303
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  • 4
    Electronic Resource
    Electronic Resource
    Serum bile acids and their conjugates in breast-fed infants with prolonged jaundice (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 37-40 
    Details
    ISSN: 1432-1076
    Keywords: Serum bile acid ; Breast milk jaundice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum bile acids and their conjugates were analysed in 20 breast-fed infants with prolonged jaundice. The mean total bile acid levels in serum were increased in the breast-fed infants with jaundice, as compared with those in either breastor bottle-fed infants without jaundice. However, there were no significant differences between the groups. All the breast-fed infants examined, regardless of association with jaundice, had a bile acid pattern dominated by taurine conjugates (the ratio of glycine- to taurine-conjugated bile acid, G/T ratio, less than 1.00). In contrast, the bottle-fed infants without jaundice had a pattern dominated by glycine conjugates (G/T ratio, more than 1.00). Among the breast-fed infants with jaundice, the mean G/T ratio in those who had serum bilirubin levels over 10 mg/100 ml was significantly lower than that in those who had serum bilirubin levels of less than 10 mg/100 ml. The altered bile acid metabolism might be associated with the pathology of breast milk jaundice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491922
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  • 5
    Electronic Resource
    Electronic Resource
    Significance of serum lipoprotein-X and gammaglutamyltranspeptidase in the diagnosis of biliary atresia. A preliminary study in 27 cholestatic young infants (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 54-57 
    Details
    ISSN: 1432-1076
    Keywords: Lipoprotein-X ; γ-Glutamyltranspeptidase ; Biliary atresia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As simple and nonsurgical means of differentiating biliary atresia (BA) from intrahepatic cholestasis of unknown origin (IC), liver function tests including serum lipoprotein-X (LP-X) and γ-glutamyltranspeptidase (GGTP) were done and evaluated for their usefulness in the diagnosis of 27 cholestatic Japanese young infants. Except for LP-X and GGTP levels (P〈0.01, P〈0.001), there were no significant differences between the BA (n=11) and IC (n=13) groups. When values of mean plus 4 standard deviations were used to differentiate BA from IC (89 mg/100 ml for LP-X and 194 IU/l for GGTP), all BA patients gave positive results for either the crtical LP-X of GGTP values. On the other hand, all IC patients gave negative results for both levels, although patients with a paucity of intrahepatic biliary ducts (n=3) were also positive for either the critical LP-X or GGTP values. The combination test with serum LP-X and GGTP is recommended for helping to differntiate BA from IC in cholestatic young infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441853
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  • 6
    Electronic Resource
    Electronic Resource
    The effects of forsterite film on total loss of grain-oriented 3% silicon iron (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 4214-4216 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Two types of mill glass, one of which is conventional and the other is characterized by its irregular surface morphology and stronger tension, were prepared on the surface of high permeability 3%Si-Fe sheets in order to clarify the effects of the mill glass on core loss and domain structure. The results are twofold. Firstly, the mill glass of the latter type was, by itself, found to reduce the total loss in the induction range of 1.7 T. Secondly, considerable change in magnetization, characterized by its heavily constricted curve occurred, and corresponding change in the domain structure was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.334617
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  • 7
    Electronic Resource
    Electronic Resource
    Patterns of polypeptide synthesis in human rotavirus infected cells (1986)
    Springer
    Archives of virology 90 (1986), S. 29-40 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Polypeptide analysis of three strains of human rotavirus (KUN, Wa and MO) were conducted using a hypertonic culture which suppressed host protein synthesis and unmasked rotavirus specific protein synthesis. As a result, eleven human rotavirus specific polypeptides (Vp 1–Vp 11) were detected by pulselabeling infected cells with [14C]-leucine. Among the 11 polypeptides, three polypeptides (Vp 7, Vp 10 and Vp 11) underwent post-translational processing, and two (Vp 7 and Vp 10) were glycosylated. Six polypeptides (Vp 1, 2, 3, 4, 6 and 7) were identified as viral structural proteins. Comparisons of three strains of different serotypes revealed that their polypeptide profiles differed from each other in electrophoretic mobility; in particular, profiles of the glycosylated polypeptide, Vp 7, were distinct among the three strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314142
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  • 8
    Electronic Resource
    Electronic Resource
    Evidence for endocytosis-independent infection by human rotavirus (1987)
    Springer
    Archives of virology 97 (1987), S. 93-99 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of five lysosomotropic drugs (NH4Cl, chloroquine, methylamine, amantadine and dansylcadaverine) and cytochalasin B on human rotavirus (HRV KUN strain) and vesicular stomatitis virus (VSV Indiana strain) infection in monkey MA 104 cells were examined. These drugs had little effect on HRV yield but greatly reduced VSV yield. The results strongly suggest that HRV does not require endocytotic activity and intracellular acidic vesicles for the initial stage of infection and support our postulate that HRV enters the target cell by direct penetration of its nucleoid through the cell membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310737
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of trypsin and chymotrypsin on polypeptides of human rotavirus KUN strain (1987)
    Springer
    Medical microbiology and immunology 176 (1987), S. 65-73 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In view of the fact that trypsin enhances the infectivity of human rotavirus and decreases its hemagglutination, the trypsin-mediated structural modification of the viral polypeptides was analysed, using the KUN strain, a cultivable human rotavirus isolate, grown in the absence of trypsin. A major polypeptide sensitive to trypsin treatment was Vp4 with a molecular weight of 80,000, being cleaved into three polypeptides with molecular weights of 54,000 (P54), 30,000 (P30), and 24, 000 (P24). Vp4 was also sensitive to chymotrypsin treatment, generating cleavage products different from those obtained with trypsin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200676
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  • 10
    Electronic Resource
    Electronic Resource
    Two modes of human rotavirus entry into MA 104 cells (1985)
    Springer
    Archives of virology 85 (1985), S. 25-34 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Entry of the KUN strain of human rotavirus into MA 104 cells was studied by electron microscopy. Virus particles attached to the cell membrane appeared to be almost exclusively double-shelled virions. These attached virions followed two distinct pathways into the cytoplasm depending on pretreatment with trypsin. Using infectious rotavirus which had been pretreated with trypsin, the viral nucleoids passed directly into the cytoplasm within 5 minutes after inoculation, through dissolution of the viral capsid and cell membrane. Using non-infectious rotavirus that had not been pretreated with trypsin, phagocytosis or pinocytosis occurred in which virions were sequestered into lysosomes 20 minutes after virus attachment to the cell membrane. After being sequestered, uncoating of the rotavirus virions within lysosomes was seen, but it did not result in release of the genome. On the basis of these observations it was concluded that when virions were pretreated with trypsin, virus replication occurred following the direct passage of viral nucleoids into the cell cytoplasm. However, mere phagocytosis of virus particles into cell lysosomes, which occurred when trypsinuntreated virus was used, does not appear to be related to rotavirus replication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317003
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