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Lidar observations of substantial sodium depletion in the summertime Arctic mesosphere (1988)

Gardner, C. S. ; Senft, D. C. ; Kwon, K. H.

[s.l.] : Nature Publishing Group

Nature 332 (1988), S. 142-144

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Fig. 1 Average sodium density profile above Nordlysstasjonen, Svalbard during the period 10-15 July 1987. The data were smoothed using modified Hamming window with full-width-half-maximum = 6 km. Fig. 2 Sodium density profile above Nordlysstasjonen, Svalbard at 21:52 UT 7 ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/332142a0

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A prospective study of clozapine in treatment-resistant schizophrenic patients (1989)

Meltzer, H. Y. ; Bastani, B. ; Kwon, K. Young ; [et al.]

Springer

Psychopharmacology 99 (1989), S. S68

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ISSN: 1432-2072

Keywords: Clozapine ; Treatment-resistant schizophrenia ; Quality of life

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Preliminary results of a non-blinded prospective study of the effect of clozapine on symptomatology and social function in 51 treatment-resistant schizophrenic patients are reported. The mean duration of treatment at the time of this report was 10.3±8.1 months, median 7.6 months. Overall, 3/51 patients (60.8%) showed at least a 20% decrease in total BPRS, a criterion of improvement in the study of Kane et al. (1988). Four of 51 (7.8%) had at least a 50% decrease in total BPRS. Improvements in both positive and negative symptoms were noted. Marked improvements in social function were noted within the first 6 months of treatment. Improvement was first noted at all time points, with only 45.2% of improvers being identified after 6 weeks of treatment. These results suggest a 6–12-month trial may be desirable before deciding to discontinue clozapine because of insufficient response. Higher total Brief Psychiatric Rating Scale (BPRS) score and higher ratings on the Paranoid Disturbance subscales of the BPRS were factors which discriminated clozapine responders from non-responders.