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  • 1
    Electronic Resource
    Electronic Resource
    Review; post-marketing surveillance of the safety of cimetidine—the problems of data interpretation (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 1 (1987), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Experience obtained during post-marketing surveillance of the safety of cimetidine emphasizes the difficulties in interpretation posed by the high background frequency of disease of all types in drug takers. The multiple sources of confounding factors, and their high prevalence, make it impossible to detect adverse events which mimic ordinary disease, particularly when a consistent relationship between adverse event and drug exposure is not observed. The inclusion of controls emphasizes the difficulties but does not ease interpretation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1987.tb00616.x
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  • 2
    Electronic Resource
    Electronic Resource
    Calbindin immunoreactivity is a characteristic of enterochromaffin-like cells (ECL cells) of the human stomach (1989)
    Springer
    Histochemistry and cell biology 92 (1989), S. 449-451 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunoreactivity for the calicium binding protein, calbinding D28k has been localized in enterochromaffin-like (ECL) cells of the human stomach. The reactivity was observed with three different antisera, raised against bovine brain, primate brain, and chicken intestinal calbindin. The ECL cells were closed endocrine cells located at the bases of the oxyntic glands. They were not found in other regions of the stomach. No other gastric endocrine cells were reactive with these antisera.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492503
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  • 3
    Electronic Resource
    Electronic Resource
    Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities (1989)
    Springer
    Experimental brain research 76 (1989), S. 467-472 
    Details
    ISSN: 1432-1106
    Keywords: Cerebral cortex ; GABA neurons ; Parvalbumin ; Calbindin ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcium ions play a key role in many aspects of neuronal behavior and certain calcium binding proteins that may influence this behavior are differentially distributed in the central nervous system. In this study it is shown that immunoreactivity for calbindin-28 and for parvalbumin is localized in separate populations of inhibitory GABA interneurons in all areas of the neocortex of Old World monkeys. Virtually all GABA neurosn show immunoreactivity for one or other calcium binding protein but, except for a few cells in layer IV, GABA cells do not show immunoreactivity for both proteins. Among the two cell populations, parvalbumin immunoreactivity characterizes basket neurons while calbindin immunoreactivity characterizes double bouquet neurons. These findings suggest that the two GABA cell types differ in their regulation of calcium homeostasis and may yield clues to their different roles in intracortical circuitry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247904
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  • 4
    Electronic Resource
    Electronic Resource
    Calbindin 28 kDa in endocrine cells of known or putative calcium-regulating function (1989)
    Springer
    Histochemistry and cell biology 91 (1989), S. 107-113 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of calbindin in some endocrine glands (thyroid, parathyroid, ultimobranchial body, pituitary and adrenals) and in the diffuse endocrine cells of the gut and pancreas has been investigated immunohistochemically using an antiserum raised against the 28 kDa calbindin from chicken duodenum. The identity of calbindin-immunoreactive cells in a number of avian and mammalian species was ascertained by comparison with hormone-reactive cells in consecutive sections or by double immunostaining of the same section with both calbindin and hormone antibodies. Calcitonin-producing C cells of the mammalian and avian thyroid, parathyroid or ultimobranchial body, PP, glucagon and insulin cells of the mammalian and avian pancreas, enteroglucagon cells of the avian intestine, secretin cells of the mammalian duodenum, histamine-producing ECL cells of the mammalian stomach, as well as noradrenaline-producing cells of the adrenal medulla and some (TSH?) cells of the adenohypophysis were among the calbindin-immunoreactive cells. Although some species variability has been observed in the intensity and distribution of the immunoreactivity, especially in the pancreas and the gut, a role for calbindin in the mechanisms of calcium-mediated endocrine cell stimulation or of intracellular and extracellular calcium homeostasis is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492384
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  • 5
    Electronic Resource
    Electronic Resource
    Alterations in platelet alpha2-adrenoceptors by aspirin (1988)
    Springer
    Inflammation research 24 (1988), S. 196-203 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Epinephrine-induced platelet aggregation (mediated through interaction with alpha2-adrenoceptors) is inhibited by aspirin. To determine if aspirin modulates alpha2-adrenoceptors, we quantitated dissociation constant (KD) and maximum number of binding sites (Bmax) on isolated platelet membranes using alpha2-antagonist3H-yohimbine in normal subjects given 650 mg of aspirin orally. Alpha2-receptor KD increased from 3.20±1.80 to 7.32±3.32 nM (p〈0.02) and Bmax from 115±77 to 190±140 fmol/mg protein. To determine if these alterations in alpha2-receptors by aspirin were mediated through circulatory or intracellular effects, intact platelets or isolated platelet membranes were incubated with aspirin for 30 minutesin vitro. In thesein vitro experiments, alpha2-receptor KD increased from 2.92±1.76 to 9.83±8.55 nM and Bmax from 140±81 to 191±129 fmol/mg protein (p〈0.05). Oral ingestion of aspirin or incubation of aspirin with intact platelets or lysates increased (3 to 10 fold) the concentration of 1-epinephrine required for inhibition, of3H-yohimbine binding by 50% (p〈0.05). Basal platelet cyclic AMP as well as its elevation with PGE1 or PGI2 and decrease with catecholamines were not influenced by aspirin treatment of platelets. These data indicate that aspirin decreases platelet alpha2-receptor affinity for agonist as well as antagonist. These effects of aspirin are independent of circulatory or dynamic intraplatelet changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968101
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  • 6
    Electronic Resource
    Electronic Resource
    Immunohistochemical evidence for the presence of calcium-binding proteins in enteric neurons (1988)
    Springer
    Cell & tissue research 252 (1988), S. 79-87 
    Details
    ISSN: 1432-0878
    Keywords: Calcium-binding protein ; Enteric nervous system ; Intestine ; Immunocytochemistry ; Guinea-pig ; Rat ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunoreactivity for vitamin D-dependent calcium-binding protein (CaBP) has been localized in nerve cell bodies and nerve fibres in the gastrointestinal tracts of guinea-pig, rat and man. CaBP immunoreactivity was found in a high proportion of nerve cell bodies of the myenteric plexus, particularly in the small intestine. It was also found in submucous neurons of the small and large intestines. Immunoreactive nerve fibres were numerous in the myenteric ganglia, and were also common in the submucous ganglia and in the intestinal mucosa. Immunoreactive fibres were rare in the circular and longitudinal muscle coats. In the myenteric ganglia of the guinea-pig small intestine the immunoreactivity is restricted to one class of nerve cell bodies, type-II neurons of Dogiel, which display calcium action potentials in their cell bodies. These neurons were also immunoreactive with antibodies to spot 35 protein, a calcium-binding protein from the cerebellum. From the distribution of their terminals and the electrophysiological properties of these neurons it is suggested they might be sensory neurons, or perhaps interneurons. The discovery of CaBP in restricted sub-groups of enteric neurons may provide an important key for the analysis of their functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213828
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  • 7
    Electronic Resource
    Electronic Resource
    Localization of 28 kDa calbindin in human odontoblasts (1988)
    Springer
    Cell & tissue research 254 (1988), S. 341-346 
    Details
    ISSN: 1432-0878
    Keywords: Odontoblast ; Calbindin ; Immunohistochemistry ; Electron microscopy ; Teeth ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The presence of 28 kDa calbindin in human odontoblasts was studied by use of specific antibodies raised against chick duodenal 28 kDa calbindin, in immunofluorescence, immuno-peroxidase, and electron-microscopic labelling experiments. The calbindin-like protein was detected mainly in the cytoplasm of odontoblast cell bodies, in their processes and occasionally in their nuclei. Correspondingly, at the ultrastructural level, immunoreactive material was associated with the cytosol, microfilaments and cilia. These findings suggest that human odontoblasts express a 28 kDa vitamin D-dependent calcium-binding protein, unlike those of rats and mice in which ameloblasts are the only cells immunoreactive for the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225806
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