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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and electrochemical characterization of siloxane polymers containing hydroquinone and 1,4-naphthohydroquinone (1989)
    s.l. : American Chemical Society
    Macromolecules 22 (1989), S. 4641-4643 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00202a043
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  • 2
    Electronic Resource
    Electronic Resource
    Ion–ion recombination studies in ambient helium and argon at atmospheric densities (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 6328-6334 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have measured the dependence on gas density of the recombination rate for the reaction H3O+(H2O)n+NO−3→neutrals for n=2,3 in helium at densities from 0.3 to 1.2 NL and in argon from 0.2 to 0.9 NL (NL =Loschmidt's number). We find that three-body recombination accounts for only part of the total observed recombination rate. The enhancement of mutual neutralization by the ambient gas appears to dominate the recombination process at low densities. A simple model is given which reproduces the experimental data fairly well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456349
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  • 3
    Electronic Resource
    Electronic Resource
    Occupational dermatosis among chrome platers (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 18 (1988), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 14 (38%) of 37 chrome platers in 17 chrome electroplating factories surveyed had occupational contact dermatitis, chrome ulcers, or both. 7 had chrome ulcers, 6 had contact dermatitis and 1 had both. Another 16 (43%) workers had scars suggestive of previous chrome ulcers. Mucosal irritation was present in 57% of the workers. The most common was throat irritation (49%) followed by nasal irritation (41%). Mucosal irritation was more common in hard chrome platers, while skin ulcers and dermatitis were more common in bright chrome platers. Nasal septum perforation was seen in 1 worker. Skin ulceration appeared to be a more specific sign for occupational dermatosis in chrome platers than dermatitis when the prevalence rates were compared to controls. Of the 7 workers with chrome ulcers, only 1 was allergic to chromate. Of the 6 workers with dermatitis, 2 were allergic to chromate and 1 to nickel. The worker with ulceration and dermatitis was negative to chromate and nickel. Irritant factors are therefore important in the aetiology of contact dermatitis in these chrome platers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1988.tb02746.x
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  • 4
    Electronic Resource
    Electronic Resource
    High pressure [4 + 2] cycloaddition reactions of 3,4-dimethoxyfuran with dichloromaleic anhydride and with cyclopropane derivatives (1986)
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 3729-3730 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00369a040
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  • 5
    Electronic Resource
    Electronic Resource
    ACTION OF MEFLOQUINE ON AGONIST-INDUCED CONTRACTIONS OF THE GUINEA-PIG ISOLATED ILEUM (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: b1. Responses of the guinea-pig isolated ileum to cumulative concentrations of acetylcholine (ACh), histamine (H), and prostaglandin E2 (PGE2) were obtained in the presence or absence of mefloquine or quinine.2. The effects of increasing the external calcium concentration and the presence of a low concentration (1.8 nmol/l) of PGE2 on the mefloquine-and quinine-induced inhibition of the ACh cumulative dose-response curves were also investigated.3. Mefloquine (1–10 μmol/l) and quinine (50–100 μmol/l) both caused a dose-dependent non-parallel right shift of the log concentration-response curve of every agonist. Mefloquine is a more potent inhibitor of PGE2-induced responses whereas quinine inhibited all three agonist-induced responses to the same extent.4. Increasing the external calcium concentration enhanced the inhibitory effects of both drugs on ACh-induced responses. Pre-incubation with 1.8 nmol/l PGE2 had a similar effect.5. The actions of mefloquine on ACh-and H-induced contractions are non-specific, like other antimalarials, but its greater inhibitory action on PGE2 may involve a more complex effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1988.tb01096.x
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  • 6
    Electronic Resource
    Electronic Resource
    ACUTE TOLERANCE TO DIAZEPAM IN MICE: PHARMACOKINETIC CONSIDERATIONS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The tolerance to the hypnotic effect of diazepam developed after a single exposure to diazepam in the presence or absence of cycloheximide, which blocks liver enzyme induction, was studied.2. At the high dose (30-35 mg/kg) used in this study, diazepam was found to be metabolized very rapidly in mice, consistent with previous findings using a much smaller dose (5 mg/kg).3. There was no significant difference in the pharmacokinetics of diazepam in control and tolerant mice as observed by monitoring the plasma and brain concentrations of diazepam and N-desmethyldiazepam.4. It is concluded that acute tolerance to diazepam in mice may not be attributed to changes in pharmacokinetic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb00329.x
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  • 7
    Electronic Resource
    Electronic Resource
    INHIBITION OF ACETYLCHOLINESTERASE BY HISTAMINE AGONISTS AND ANTAGONISTS (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The histamine H1 and/or H2-receptor agonists showed weak acetylcholinesterase inhibitory activity. Their dissociation constants (Kis and/or Kii) were 2-methyl histamine (Kis= 1751 μmol/1, s.e. = 163) 〈 4-methyl histamine (Kis= 3551 μmol/1, s.e. = 414) 〈 dimaprit (Kis= 2931 μmol/1, s.e. = 605; Kii= 3668 μmol/1, s.e. = 901) 〈 histamine (Kis= 6480 μmol/1, s.e. = 1360).2. Both histamine H1 and H2-receptor antagonists showed stronger acetylcholin-esterase inhibitory activity. Their dissociation constants were ranitidine (Kii= 1.56 μmol/1, s.e. = 0.14) ≪ oxmetidine (Kis= 14.7 μmol/1, s.e. = 1) 〈 mepyramine (Kis= 178 μmol/1, s.e. = 23; Kii= 440 μmol/1, s.e. = 98) 〈 cimetidine (Kis= 199 μmol/1, s.e. = 12; Kii= 827 μmol/1, s.e. = 126).3. Using the ROSFIT programs for fitting data to common enzyme kinetic models, the inhibition caused by histamine, 4-methyl histamine, 2-methyl histamine, oxmetidine and neostigmine was of the competitive type. Mepyramine, cimetidine and dimaprit appeared to exhibit the modern non-competitive type of inhibition with their primary action on the enzyme rather than on the enzyme-substrate complex. Ranitidine seemed to act on the enzyme-substrate complex rather than the enzyme, conforming to the uncompetitive inhibition model.4. The clinical implications of acetylcholinesterase inhibition by cimetidine and ranitidine are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb00915.x
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  • 8
    Electronic Resource
    Electronic Resource
    GANGLION BLOCKING ACTIVITY OF CIMETIDINE IN THE ANAESTHETIZED CAT (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Cimetidine produced a dose-dependent and reversible inhibition of contractions of the nictitating membrane elicited through stimulation of the preganglionic nerve supplying the superior cervical ganglion in the anaesthetized cat. Postganglionic nerve stimulation resulted in only a slight and variable inhibition of the contractions. Both hexamethonium and cimetidine also produced a dose-dependent and reversible fall in arterial blood pressure.2. The ganglion blocking activity of cimetidine was much weaker than that of hexamethonium; the ED50 ratio (cimetidine:hexamethonium) calculated from the cumulative log dose-response curves for the two drugs was 64.3. The possible mechanism(s) of ganglion blockade produced by cimetidine is discussed including a possible action at nicotinic receptors, either directly or indirectly (via its anticholinesterase activity), and ion channel blockade.4. The clinical implications of cimetidine-induced ganglionic blockade are also discussed, especially with respect to sexual impotence associated with the use of cimetidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb00897.x
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  • 9
    Electronic Resource
    Electronic Resource
    ANTICHOLINESTERASE ACTIVITY OF AND POSSIBLE ION-CHANNEL BLOCK BY CIMETIDINE, RANITIDINE AND OXMETIDINE IN THE TOAD ISOLATED RECTUS ABDOMINIS MUSCLE (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Responses of the toad isolated rectus abdominis muscle to cumulative doses of acetylcholine were recorded in the absence or presence of varying concentrations of cimetidine, ranitidine or oxmetidine. The corresponding cumulative log concentration-response curves for acetylcholine were then plotted for each antagonist studied.2. Cimetidine (5 mmol/1), ranitidine (1 mmol/1) and oxmetidine (0.02 mmol/1) potentiated the effect of acetylcholine by 4-fold, 2.6-fold and 1.3-fold, respectively.3. At higher concentrations all three histamine H2-receptor antagonists produced a concentration-dependent and non-parallel shift of the acetylcholine curve to the right of the corresponding control curve accompanied by a depression of the maximal response.4. The results provide further evidence that the H2-antagonists studied possess anticholinesterase activity and also suggest that the H2-antagonists may produce neuromuscular blockade by ion-channel block. The clinical implications of the results obtained are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb00882.x
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  • 10
    Electronic Resource
    Electronic Resource
    Gas filter correlation instrument for the remote sensing of gas leaks (1985)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 1812-1819 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An airborne remote sensor named GASPILS (gas pipeline leak sensor) has been developed and tested to detect leaks from natural gas pipelines by monitoring the amount of methane in the atmosphere above the leak. The sensor is a passive electro-optical system, with two independent channels, operating in a downward-looking profiling mode. It is designed to detect increases in the low levels of methane concentration by sensing the infrared spectral radiance signatures using a nondispersive gas filter correlation technique. This technique involves the use of a gas cell as a matched spectral filter, and it combines a high degree of sensitivity to the target gas with a high degree of specificity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138100
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