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  • 1985-1989  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    RILMENIDINE ACTS AS A PARTIAL AGONIST AT PREJUNCTIONAL α2-ADRENOCEPTORS IN GUINEA-PIG ATRIA (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The present study was carried out to determine whether rilmenidine, a recently introduced antihypertensive agent which acts on α2-adrenoceptors, has partial agonist activity on prejunctional α2-adrenoceptors in guinea-pig atria.2. Isolated preparations of guinea-pig atria were incubated with [3H]-noradrenaline and the efflux of radioactivity induced by stimulation of intramural sympathetic nerves was used as an index of release of transmitter noradrenaline.3. Rilmenidine (1 μmol/1) inhibited noradrenaline release evoked by short trains (five, 20 and 50 pulses) of sympathetic nerve stimulation and this inhibitory effect of rilmenidine was antagonized by the α2-adrenoceptor antagonists, idazoxan (0.1 and 0.3 umol/1) and rauwolscine (0.3 umol/1) whereas it was not affected by the α1-adrenoceptor antagonist prazosin (0.1 μmol/1).4. On the other hand, rilmenidine (1 μmol/1) enhanced noradrenaline release evoked by long trains (150 and 300 pulses) of stimulation and this effect was also abolished by idazoxan (0.1 μmol/1).5. These findings suggest that the effects of rilmenidine on transmitter release depend on the degree of auto-inhibition: when the concentration of noradrenaline in the biophase of the prejunctional α2-adrenoceptors is low, rilmenidine acts as an agonist, but when the concentration is high it acts as an antagonist. Thus, rilmenidine, like clonidine, is a partial agonist on prejunctional α2-adrenoceptors in guinea-pig atria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1988.tb01016.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EVIDENCE FOR A ROLE OF NITRIC OXIDE IN THE NEUROTRANSMITTER SYSTEM MEDIATING RELAXATION OF THE RAT ANOCOCCYGEUS MUSCLEC (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The nitric oxide (NO) synthesis inhibitor NG-monomethyl-l-arginine (l-NMMA), but not d-NMMA, inhibited the NANC-mediated relaxations of the rat anococcygeus muscle, but did not affect the relaxation produced by sodium nitroprusside.2. The inhibitory effect of l-NMMA was reversed by l-arginine but not by d-arginine, and prior exposure to l-arginine blocked the effect of l-NMMA.3. The noradrenergically mediated contractions of the anococcygeus elicited by field stimulation were slightly enhanced by l-NMMA, but the response to noradrenaline was not affected.4. The results suggest that NANC transmission in the rat anococcygeus muscle involves the generation of NO from arginine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb02404.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tensile fatigue of glass fibers and composites with conventional and surface compressed fibersPrepared for 40th Annual Conference, Reinforced Plastics/Composites Institute, Society of the Plastics Industry, January 1985, Atlanta (Paper 7-G). (1985)
    Brookfield, Conn. : Wiley-Blackwell
    Polymer Composites 6 (1985), S. 168-174 
    Details
    ISSN: 0272-8397
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The mechanism of tensile cyclic fatigue failure in conventional glass fiber dominated composites has been investigated using single fibers, strands, and composites. Surface damage to the fibers resulting from a fretting type of contact is identified as the dominant mechanism. Macrofibers of glass or glassceramic with residual surface compression have been developed to overcome the sensitivity both to cyclic and static fatigue. The macrofibers and their composites with several different matrices show greatly improved tensile fatigue resistance.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pc.750060307
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    Paper (German National Licenses)
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