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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 62 (1986), S. 250-258 
    ISSN: 1432-1106
    Keywords: Longterm potentiation ; Hippocampus ; Collateral specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Long term potentiation (LTP) in response to brief high frequency trains has been reported for many pathways in the hippocampus. The mechanisms involved are still unclear. The present experiments set out to confirm reports in the literature that LTP of output from CA3 neurons can be specific to particular collaterals. Single pulses delivered to area CA3 produced field responses nearly simultaneously in area CA1 and in the lateral septum (LS). High frequency stimulation of CA3 produced long term potentiation of CA1 but not LS responses. The CA1 response to stimulation of the contralateral hippocampus did not potentiate when the CA1 response to CA3 stimulation showed long term potentiation. The CA1 and LS responses to CA3 stimulation showed similar strength-duration, strength-amplitude and frequency following characteristics. Their latencies were comparable to the latencies of antidromic activation of CA3 cells from CA1 and LS. Movement of stimulating electrodes to the region of the Schaffer collaterals increased the latency of the LS response and decreased the latency of the CA1 response but left the sum of these latencies unchanged. It was concluded that the CA3 and Schaffer stimulation were activating LS and CA1 collaterals of the same CA3 neurons. CA1 and LS responses to CA3 stimulation showed somewhat different paired pulse and frequency potentiation characteristics. These data confirm reports in the literature that long term potentiation is both input-specific and collateral-specific. The mechanisms of long term potentiation are likely, therefore, to be limited to changes at specific synaptic junctions, e.g. changes in sensitivity of specific postsynaptic receptor sites or changes in transmitter release, which can depend on functional or organisational differences between two collaterals of the same neuron.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 57 (1985), S. 443-447 
    ISSN: 1432-1106
    Keywords: Epilepsy ; GABA ; Hippocampus ; Inhibition ; Kindling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vitro hippocampal slices were prepared from control and commissural-kindled rats and the inhibitory processes of the dentate granule cells were assessed using paired perforant path stimulation. An early (20 ms) Cl--dependent and a late (200 ms-8 s) Cl--independent inhibition were shown to be present in the dentate. Enhancement of the late Cl--insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 1803-1812 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper we introduce finite element methods of Petrov-Galerkin type for the approximate solution of two-point boundary-value problems for singularly perturbed, second-order, ordinary, linear differential equations. We write down Petrov-Galerkin methods on a uniform mesh which have asymptotic error estimates, as the mesh size tends to zero, whose magnitude is independent of the singular perturbation parameter. This is in marked contrast to standard finite element methods which do not possess such a property on a uniform mesh. For these, typically, the error on a fixed uniform mesh blows up as the singular perturbation parameter tends to zero.This robust behaviour of these Petrov-Galerkin methods for singularly perturbed problems is achieved by choosing trial spaces of standard piecewise polynomial type, while the test spaces consist of hinged piecewise polynomials.We consider self-adjoint and non-self-adjoint two-point boundary-value problems with Dirichlet boundary conditions. We define hinged test spaces for both types of problem. We then introduce a number of sample problems and we present numerical solutions of these sample problems using a Petrov-Galerkin method with the appropriate hinged test space.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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