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Intramuscular bioavailability of chlorazepate as compared to diazepam (1985)

Bertler, Å. ; Lindgren, S. ; Magnusson, J. -O. ; [et al.]

Springer

European journal of clinical pharmacology 28 (1985), S. 229-230

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ISSN: 1432-1041

Keywords: diazepam ; dipotassiumchlorazepate ; benzodiazepines ; bioavailability ; administration ; healthy volunteers

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 µmol) DPC and 15 mg (52.0 µmol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00609698

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