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  • 1
    ISSN: 1432-1076
    Keywords: Respiratory distress syndrome ; Surfactant replacement ; Bronchopulmonary dysplasia ; Intraventricular haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We conducted a prospective, randomized, controlled trial comparing the efficacy of two doses of a reconstituted bovine surfactant (Surfactant TA) in premature infants requiring mechanical ventilation shortly after birth for respiratory distress syndrome. Forty-six infants weighing 1000–1499 g were randomized into two groups: a low-dose group (23 infants given a single dose of 60 mg surfactant lipid/kg) and a high-dose group (23 infants given a single dose of 120 mg/kg). The mean (SD) age at which surfactant was given was 5.5 (±1.2) h in the low-dose group and 6.0 (±1.5) h in the high dose group. Both treatments improved oxygenation (increased arterial-alvcolar PO2 ratio) with decreased mean airway pressure, the high-dose surfactant having a more beneficial effect in prolonging the response. Infants in the high-dose group had significantly less (P〈0.05) incidence of both intraventricular haemorrhage and bronchopulmonary dysplasia. This prospective trial documents that a greater benefit can be obtained by increasing the dose of surfactant (120 mg/kg) beyond 60 mg/kg in the treatment of premature infants with severe respiratory distress syndrome (RDS).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Irradiation experiments on biological samples with monochromatic ultrasoft x-rays are inevitable in elucidating the initial process in radiobiological phenomena. However, intense light sources with continuous spectra in this wavelength region have not been available until recently. Synchrotron radiation is the best light source for the study because of its intense, continuous emission spectrum. The purpose of the project is to develop a grazing incidence ultrasoft x-ray monochromator for radiation biology studies using synchrotron radiation as a light source. The following characteristics are required in the monochromator, namely, (1) high throughput with moderate resolution; (2) wide beam area with uniform intensity; (3) little contamination of higher order lights; and (4) easy operation and maintenance. Considering the above requirements, a plane-grating type monochromator (PGM) is adopted. The monochromator consists of two premirrors (M1 and M2), a plane grating (1200 l/mm), a concave focusing mirror (r=12 m) and an exit slit. Two premirrors with different incident angles can be used interchangeably to eliminate higher order lights in the desired wavelength region. Wavelength of 30–70 A is available when M1 is used and 80–250 A when M2 is used. Expected wavelength resolution is 1% when the width of exit slit is 300 μm. All vacuum chambers accommodating these optical elements are bakable in order to attain ultrahigh vacuum. Wavelength is controlled by a microcomputer system equipped with a stepping motor and an encoder. This monochromator will be installed at beamline 12C at the Photon Factory, National Laboratory for High Energy Physics, and will be open to outside users in radiation biology by the end of 1988.
    Type of Medium: Electronic Resource
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