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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 81 (1986), S. 94-99 
    ISSN: 0942-0940
    Keywords: Primitive glioma ; ependymoblastoma ; undifferentiated glioma ; unclassified glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the biological features of primitive gliomas in the cerebrum and clearly distinguish them from malignant or anaplastic gliomas and glioblastomas, we studied eight cases clinically and pathologically. Our evaluations included immunohistochemical and electron microscopic observations. We divided the patients into two groups, children and young adults. Most tumours appeared as ring-like, enhanced masses on computed tomography and avascular or ring-like, vascular masses on angiography. Macroscopically, the tumours were well demarcated and contained cysts. Ocassionally we found tumour dissemination. Microscopically, the tumours were composed of small, round cells without remarkable structural features. Ependymal, astroglial, and oligodendroglial differentiation was evident, in varying proportions; tumours in which the differentiated areas constituted more than half of the mass were classified as poorly differentiated gliomas. By these criteria, this series comprised four undifferentiated and four poorly differentiated gliomas. Cell anaplasia and polymorphism were rare in both undifferentiated and differentiated areas of the tumours. Immunohistochemical and electron microscopic examinations also revealed glial differentiation. These primitive gliomas appear to be biologically similar, but not identical, to cerebellar medulloblastomas. In this series, five patients died because of recurrence or dissemination. Whole brain and spinal irradiation should be considered after total or subtotal surgical removal.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 1901-1904 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A three-dimensional computer model was used to study the scattering of a reflected lithium ion beam by an electrostatic reflector. Results show that for ion gun systems for active space plasma experiment applications, beam scattering of less than 1° can be attained with electrostatic reflectors.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 22 (1987), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bacteroides gingivalis produces large amounts of proteolytic enzymes which may play a role in its virulence. These enzymes may participate in the tissue destruction of the inflammatory process. In this study, the characteristics of two such enzymes, N-CBz-glycyl-glycyl-arginyl peptidase (N-CBz-Gly-Gly-Arg peptidase) and glycyl-prolyl peptidase (Gly-Pro peptidase) were investigated. The enzymes eluted in different peaks from an anion exchange column. N-CBz-Gly-Gly-Arg peptidase was associated with cells up to 48 h in culture. If cultured longer, it also released in the supernatant. It exhibited optimal activity between pH of 7.0 and 7.5 and was readily inactivated by heat treatment (45°C for 15 min). The enzyme activity was inhibited by p-chloromercuribenzoic acid (PCMB), leupeptin and antipain, suggesting that it is a thiol protease. The B. gingivalis N-CBz-Gly-Gly-Arg peptidase was different from the serum enzyme that digests the same substrate. The serum enzyme was more resistant to heat treatment and was inhibited by diisopro-pylfluorophosphate (DFP). B. gingivalis also produced Gly-Pro peptidase that is released in the supernatant. The enzyme has an optimal pH range between 7.5 and 8.0. The B. gingivalis Gly-Pro peptidase was inhibited by DFP, suggesting that it represents a serine protease. The serum Gly-Pro peptidase did not differ from the bacterial enzyme with respect to its sensitivity to inhibitors; however, they were markedly different in heat sensitivity. The bacterial enzyme was completely inactivated at 60°C for 30 min, whereas the serum enzyme was not inactivated even at 1 h at 60°C.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Veterinary research communications 9 (1985), S. 147-152 
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six fasciolicides, bithionol, bromofenofos, DS-6, nitroxynil, oxyclozanide and tribromsalan, were tested for mutagenicity in theSalmonella reverse mutation test usingS.typhimurium tester strains TA100, TA98, TA153, TA1537 and TA1538 and the micronucleus test in mice. None of the fasciolicides increased the number of revertant colonies in any tester strain in the presence and absence of S9 mix, nor did they induce a significant increase of the micronuclei in erythrocytes. Taking the high correlation between mutagenicity and carcinogenicity into consideration, these results suggest that the fasciolicides tested in this investigation are devoid of carcinogenic action.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 188-192 
    ISSN: 1432-1335
    Keywords: Experimental nervous system tumor ; Radiation therapy ; Misonidazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rat brain tumor was used as a model to evaluate radiation therapy with and without misonidazole. BD-IX rats were implanted intracerebrally with an ethylnitrosourea-induced glioma. Three series of experiments were performed, with radiation given 14 days after inoculation of the glioma clone. In each series, the following radiation doses were given: 500 rads once, 1,000 rads once; and 1,000 rads twice, every time with or without two different doses of misonidazole. Radiation therapy significantly prolonged survival when compared to the longevity of the control group. The dose of 1,000 rads given twice was highly effective and the life-span of tumor-bearing rats increased from 72% to 121%. Misonidazole plus irradiation negated the prolongation of survival, achieved with radiation therapy alone.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 325 (1987), S. 617-620 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We identified the subplate and marginal zone cells unam-bigously by their birthdate. These cells undergo their final round of cell division and migrate away from the ventricular zone between embryonic day 24 (E24) and E30 (gestation is 65 days in the cat)1. In contrast, cells of the cortical layers ...
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of the bivalveCorbicula japonica on the nitrogen cycle in Lake Shinji, a mesohaline brackish lagoon in Japan, was examined quantitatively based on field surveys and laboratory experiments carried out in the summer of 1982 and 1983. The biomass of the flesh ofC. japonica comprised 97% of the total biomass of the macrozoobenthos in summer. Total biomass ofC. japonica in the lake was estimated 30 986 t fresh wt. The concentration of suspended solids immediately above the lake bottom, whereC. japonica filters the water, was 1.5 to 4 times higher than that in the surface water. In laboratory experiments, the filtration rate was 5.0 litres g dry flesh wt-1 h-1, the excretion rates of ammonia and of feces and pseudofeces ofC. japonica were 200×10-6 g N g dry flesh wt-1 h-1 and 33.4 mg dry wt g dry flesh wt-1 h-1, respectively at 27°C, the average summer water temperature in the lake. From our study, we estimated thatC. japonica filters almost the same amounts of particulate organic nitrogen produced in the lake by phytoplankton and that supplied from rivers, and that it excretes 30% of filtered nitrogen as feces or pseudofeces and 18% as ammonia.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 41 (1988), S. 12-16 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 92 (1989), S. 225-230 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mandibular condyles of 4-week-old Wistar strain rats and mandibles of ICR strain mice from 14 days gestation stage to 2 days postnatal stage were used to investigate the localization of Maclura pomifera lectin (MPA) during two modes of osteogenesis. During endochondral ossification of the mandibular condyle, MPA was only localized at the peripheral regions of calcified cartilage after the destruction of chondrocyte lacunae. Bone extracellular matrix (ECM) was not reacted with MPA. In intramembranous ossification of mice mandibles, MPA was stained intensively in the early bone ECM. The intensity of the MPA reaction decreased during bone development. In both cases of osteogenesis, chondroclasts and osteoclasts showed the strong affinity to MPA. These results indicated that the time- and position-specific changes within ECM proceeded during osteogenesis and that MPA was the useful probe to detect chondroclasts and osteoclasts.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1912
    Keywords: l-threo-DOPS ; Imipramine ; Nialamide ; Reserpine ; Ptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of l-threo-DOPS on the reserpine-induced ptosis in mice and its modification by imipramine, a norepinephrine (NE) uptake inhibitor, or nialamide, a monoamineoxidase inhibitor, were studied. Intraperitoneal (i.p.) injection of l-threo-DOPS (800 mg/kg) significantly reduced the severity of the ptosis. This reversal of the ptosis by l-threo-DOPS was markedly potentiated by i.p. injection of either imipramine (2.5 mg/kg) or nialamide (30 mg/kg). Response to l-threo-DOPS was also significantly potentiated by intracerebroventricular (i.c.v.) injection of imipramine (10 μg). On the other hand, this treatment with imipramine (10 μg, i.c.v.) also significantly potentiated the reversal of the ptosis by NE (20 μg, i.c.v.), but the reversal by the subcutaneous (s.c.) injection of NE (1 and 3 mg/kg) was not affected. Reserpine (5 mg/kg, i.p.) markedly decreased the brain content of NE in mice, whereas l-threo-DOPS (400 mg/kg, i.p.) slightly restored it. Moreover, by the pretreatment with nialamide (30 mg/kg, i.p.), l-threo-DOPS produced a significant increase in the brain content of NE in reserpinetreated mice. These results suggested that l-threo-DOPS was capable of reversing the reserpine-induced ptosis due to the formation, at least in part of (−)-NE at the synaptic sites of central noradrenergic neurons.
    Type of Medium: Electronic Resource
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