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  • 1
    Electronic Resource
    Electronic Resource
    5′-flanking DNA of the human insulin receptor gene and long terminal repeat of mouse mammary tumour virus bind to the same nuclear protein(s) (1989)
    Springer
    Diabetologia 32 (1989), S. 877-880 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; glucocorticoid responsive element ; gel mobility shift analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The interaction of nuclear protein extracted from rat liver and 5′-flanking DNA of the human insulin receptor gene was investigated with the aid of gel mobility shift analysis. When 5′-flanking DNA (-1255/-1206 or -385/-345 base pairs) was incubated with nuclear protein, two or three 32P-DNA species (protein binding DNA fragment(s) and free DNA fragment) were detected. These bands did not disappear in spite of increasing amounts of synthetic poly(dI-dC), showing that nuclear protein binds specifically to 5′-flanking DNA of the insulin receptor gene. Increasing amounts of long terminal repeat of mouse mammary tumour virus resulted in a reciprocal decrease in nuclear protein binding to 5′-flanking DNA of insulin receptor gene. These results suggest that 5′-flanking DNA of insulin receptor gene binds to the same nuclear protein to which long terminal repeat of mouse mammary tumour binds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297453
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  • 2
    Electronic Resource
    Electronic Resource
    Intracellular pH regulation in the mouse lacrimal gland acinar cells (1988)
    Springer
    The journal of membrane biology 101 (1988), S. 73-81 
    Details
    ISSN: 1432-1424
    Keywords: intracellualr pH ; lacrimal gland ; amiloride ; DIDS ; Na+/H+ antiport ; Cl−/HCO 3 − ; antiport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Intracellular pH (pH i ) of the acinar cells of the isolated, superfused mouse lacrimal gland has been measured using pH-sensitive microelectrodes. Under nonstimulated condition pH i was 7.25, which was about 0.5 unit higher than the equilibrium pH. Alterations of the external pH by ±0.4 unit shifted pH i only by ±0.08 unit. The intracellular buffering value determined by applications of 25mm NH 4 + and bicarbonate buffer solution gassed with 5% CO2/95% O2 was 26 and 46mm/pH, respectively Stimulation with 1 μm acetylcholine (ACh) caused a transient, small decrease and then a sustained increase in pH i . In the presence of amiloride (0.1mm) or the absence of Na+, application of ACh caused a significant decrease in pH i and removal of amiloride or replacement with Na+-containing saline, respectively, rapidly increased the pH i . Pretreatment with DIDS (0.2mm) did not change the pH i of the nonstimulated conditions; however, it significantly enhanced the increase in pH i induced by ACh. The present results showed that (i) there is an active acid extrusion mechanism that is stimulated by ACh; (ii) stimulation with ACh enhances the rate of acid production in the acinar cells; and (iii) the acid extrusion mechanism is inhibited by amiloride addition to and Na+ removal from the bath solution. We suggest that both Na+/H+ and HCO 3 − /Cl− exchange transport mechanisms are taking roles in the intracellular pH regulation in the lacrimal gland acinar cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872822
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  • 3
    Electronic Resource
    Electronic Resource
    The pharmacokinetics ofα-human atrial natriuretic polypeptide in healthy subjects (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 101-103 
    Details
    ISSN: 1432-1041
    Keywords: atrial natriuretic polypeptide ; α-hANP ; pharmacokinetics ; radioimmunassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have analysed the pharmacokinetics ofα-human atrial natriuretic polypeptide (α-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7±0.07 min and 13.3±1.69 min respectively. V1 (the volume of the central compartment), Vz (volume of distribution) and Vss (volume of distribution at steady-state) were 5370±855 ml (89.5±14.3 ml·kg−1), 32000±4620 ml (533±77.0 ml·kg−1), and 11900±1530 ml (198±25.5 ml·kg−1) respectively. The mean plasma clearance was 1520±121 ml·min−1 (25.4±2.0 ml·min−1·kg−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870995
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  • 4
    Electronic Resource
    Electronic Resource
    Breakdown of alumina rf windows : International conference on synchrotron radiation instrumentation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1736-1739 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The breakdown of alumina rf windows being used in high-power rf systems of accelerators has been investigated. The puncture and the thermal fracture often taking place in s-band pulsed rf systems and in UHF cw rf systems, respectively, are found to be induced by alumina surface heating due to an electron multipactor bombardment accompanied by a luminescence of alumina. It is ascertained that TiN coatings on the alumina window suppress the multipactor, and that the window duration for breakdown is dependent on the microstruture of the alumina ceramic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140942
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of the gas flow rate and the circuit parameters of the spark gap side on characteristics of LC inversion TE N2 laser (1987)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 1621-1625 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Design criteria for a N2 laser with LC inversion excitation circuit are theoretically and experimentally described. Lower resistance, depending on the spark gap pressure, gave higher energy, while the inductance was independent of it. Laser energy increased with higher gas flow rate and was saturated at rates over 10 l/min. Other experimental relationships between pulse width, gas flow rate, energy, and repetition rate are described. Typically, an energy of 4.6 mJ, a peak power of 700 kW, a pulse width of 6.6 ns, and an efficiency of 0.18% was obtained at a repetition rate of 0.4 pps, a gas flow rate 10 l/min, and a voltage of 15 kV. For a higher repetition rate of 10 pps the parameters were 3 mJ, 400 kW, 7.5 ns, and 0.12%, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1139357
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  • 6
    Electronic Resource
    Electronic Resource
    Arsenic-rich melt effect on threshold voltage scattering for Si-implanted GaAs metal-semiconductor field-effect transistor (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 846-850 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The microscopic electrical activation efficiency of implanted Si atoms in undoped, liquid-encapsulated Czochralski-grown GaAs substrates was investigated by means of the threshold voltage (Vth) of implanted metal-semiconductor field-effect transistors as a function of stoichiometry and impurities, especially of carbon as determined by Fourier transform infrared (FT-IR) spectroscopy (≤2.5×1016 cm−3). The Vth scattering, which is related to the electrical activation efficiency dispersion, was small for an As-rich substrate grown from an As-rich melt, whether or not there existed a horizontal 3400-Oe magnetic field. The smallest amplitude of the Vth scattering occurred for the As-rich melt and did not vary with magnetic field. The Vth scattering with magnetic field was independent of carbon concentration (≤2.5×1016 cm−3). However, without magnetic field, an effect clearly appeared at low carbon concentration (nearly nondetectable). It seems that the Vth scattering or the electrical activation efficiency dispersion is dominated by the dispersion of stoichiometry, that is, composition, of the GaAs substrate because the electrical activation efficiency depends on the ratio of the Ga vacancy concentration and As vacancy concentration and the magnitude of their concentrations at the annealing temperature for the Si-implanted GaAs substrate. Therefore small Vth scattering means that the dispersion of the composition (Ga and As) is small. The composition dispersion for the most As-rich melt is small because the solidification is controlled by the straight As-rich side solidus line of the Ga:As composition-temperature phase diagram, and thus temperature variations of the GaAs melt in the pyrolytic boron nitride crucible are not as important. Also, there was no correlation between Vth scattering and dislocation density.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.343076
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  • 7
    Electronic Resource
    Electronic Resource
    A parameter representing eddy current loss of soft magnetic materials and its constitutive equation (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 5684-5686 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Previously, Sakaki has proposed a parameter which is closely related to eddy current loss of soft magnetic materials. Also, Saito has proposed a similar parameter to represent the magnetization characteristics exhibiting hysteresis loops. In this paper, we show that these independently proposed parameters are essentially the same ones, and lead to a constitutive equation corresponding to a Chua-type magnetization model. Furthermore, a relationship between our proposed parameter and domain walls is examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.342274
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of the addition of a third element in a high silicon-iron alloy (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 5682-5683 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Concerning the decrease of the wall motion resistive magnetic properties such as magnetocrystalline anisotropy of an electric sheet, we reported that quick quenching from 1100 °C suppressed the formation of a B2 superlattice which is roughly proportional to the anisotropy. Using iron single crystals containing 5.5 wt. % silicon with the addition of a small amount of a third element such as Mo to suppress the formation of the superlattice, we describe the quenching temperature dependence of the anisotropy and saturation magnetization. A remarkable decrease of room-temperature anisotropy was found in crystals with the additional element compared to those without the element.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.342273
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  • 9
    Electronic Resource
    Electronic Resource
    Energy enhancement and volume effect between parallel and transverse gas flow N2 laser (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 63 (1988), S. 2526-2528 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect of gas flow parallel and transverse to the optical path and of the volume of the laser tube on N2 laser energy and pulse width was experimentally investigated. Energy enhancements of more than a factor of 2 are clearly seen in transverse flow as compared with parallel flow. Gas flowrate affects the energy more in lasers with a large volume. Pulse widths in lasers with transverse flow are shorter than those with parallel flow by about 2 ns. These results show that both the direction of gas flow and the volume of the laser tube are important parameters to adjust to increase energy and power.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.341011
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  • 10
    Electronic Resource
    Electronic Resource
    Modeling of magnetization characteristics and faster magnetodynamic field computation (invited) (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 63 (1988), S. 3174-3178 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A Chua-type magnetization model is derived by means of a Fourier series while the magnetic flux density is sinusoidally varying with time. It is shown that this Chua-type model is well suited for practical computations of magnetodynamic field. A geometrical duality between the Delaunay triangles and associated Voronoi polygons is utilized to implement a dual energy finite element approach. As an example, the magnetodynamic fields in a toroidal reactor including the effects of transients, eddy currents, and hysteresis are computed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.340830
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