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  • 1985-1989  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of Acute Ascorbic Acid Deficiency on the Plasma Lipids and Postheparin Lipolytic Activity in Guinea Pigs (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 498 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb23784.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Design of liposomes to improve delivery of amphotericin-B in the treatment of aspergillosis (1989)
    Springer
    Molecular and cellular biochemistry 91 (1989), S. 85-90 
    Details
    ISSN: 1573-4919
    Keywords: liposome ; aspergillosis ; mannose ; amphotericin-B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The efficacy and toxicity of free and liposome intercalated amphotericin-B (Amp-B) in controlling Aspergillosis, caused byAspergillus fumigatus in BALB/c mice were studied. Liposomal Amp-B had higher LD50 (8.1 mg/kg) as compared to that of the free drug (1.2 mg/kg). An improvement in the therapeutic index of the drug was observed with liposomal formulation of the drug. We also focussed on the effect of lipid composition and surface sugar in modulating the therapeutic potency of Amp-B. The most effective liposomal preparation was composed of egg phosphatidylcholine (EPC) : L-α-phosphatidylethanolamine, dipalmitoyl (DPPE): cholesterol (Chol) in the molar ratio of 6:1:3. Amp-B intercalated into mannose grafted liposomes (LD50 = 9.3 mg/kg) was more effective as compared to the other formulation tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228082
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Absorption studies after massive small bowel resection and antiperistaltic colon interposition in rhesus monkeys (1985)
    Springer
    Digestive diseases and sciences 30 (1985), S. 483-488 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An experimental model of massive (80%) small bowel resection and antiperistaltic colon interposition in between the remnant jejunum and ileum was created in rhesus monkeys. The gastrointestinal functions were assessed preoperatively and at different periods after the operation. Progressive increase in the transit time and enhanced absorption ofd-xylose and vitamin B 12 was observed in these animals. The transit time marginally increased till three months postoperatively, and a significant increase was observed later (4–12 months) in the colon autografted monkeys. After three months, thed-xylose absorption in the colon interpositioned animals was nearly equal to that of normal monkeys. There was no significant difference in the vitamin B 12 absorption in the normal and operated animals up to three months, but a significant rise was observed in the latter group after this period. The fecal fat excretion was 33–44% initially, and it gradually decreased to near normal values after nine months. The antiperistaltic colon interposition was effective in improving the early postoperative survival in animals after massive small bowel resection and enhanced the bowel absorption considerably.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318183
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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