Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Carcinogenicity of small doses of inhaled N-nitrosoacetoxymethyl-N-methylamine in Syrian golden hamsters (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 108-109 
    Details
    ISSN: 1432-1335
    Keywords: N-nitroso-N-acetoxymethyl-N-methylamine ; Syrian golden hamster ; Inhalation ; Tumors of the nasal cavities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male Syrian golden hamsters inhaled 0.5–1 ppm (=2.7–5.5 mg/m3) of N-nitroso-N-acetoxymethyl-N-methylamine 1 h/week, for 14 weeks. The total dose per animal was calculated as 150–400 μg or 1–3 mg/kg. Four squamous cell carcinomas and one mucoepidermoid carcinoma of the nasal mucosa were observed. No such tumors occurred in the control group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400746
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Genotoxic activities of benzamidine and itsN-hydroxylated metabolite benzamidoxime inSalmonella typhimurium and mammalian cells (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 363-368 
    Details
    ISSN: 1432-1335
    Keywords: Benzamidine ; Benzamidoxime ; Mutagenicity ; Salmonella typhimurium ; DNA single-strand breaks ; DNA amplification ; Metabolic conjugates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The genotoxic potentials of benzamidine and benzamidoxime were determined to study the toxicological relevance of the metabolicN-oxygenation (N-hydroxylation) of benzamidines to benzamidoximes. Benzamidoxime induced DNA single-strand breaks (in rat hepatocytes) and DNA amplification in SV40-transformed hamster cells. In the experiments performed, benzamidine itself was only marginally positive in the hepatocyte/DNA single-strand break assay. Since these cells possess an intact metabolization apparatus, the biological activities may be attributed to toxic and genotoxic metabolites formed by biotransformation. In theSalmonella typhimurium mutagenicity test (TA 98 and TA 100) benzamidoxime alone exhibited a low mutagenicity in the TA 98 strain in the presence of rabbit liver S-9 fractions. These results permit recognition of the metabolicN-hydroxylation of benzamidines to benzamidoximes as a process to toxication. Indirect evidence for the formation of a glucuronide of benzamidoxime has been obtained from in vitro experiments, but it could not be established that this process was a decisive factor in the genotoxicity of benzamidoxime.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02128179
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Determination of DNA single strand breaks and selective DNA amplification by N-nitrodimethylamine and analogs, and estimation of the indicator cells' metabolic capacities (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 123-128 
    Details
    ISSN: 1432-1335
    Keywords: Nitroalkylamines ; Hepatocytes ; Metabolizing enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N-nitrodimethylamine is metabolized oxidatively to N-nitrohydroxymethylmethylamine, which decomposes to yield formaldehyde and N-nitromethylamine. All four compounds and N-nitroethylamine were tested for their ability to induce DNA single strand breaks in hepatocytes and in SV 40-transformed Chinese hamster embryo cell lines. Only the two monoalkylnitramines were positive. They induced single strand breaks in hepatocytes, but were not effective in the other cells. Formaldehyde and N-nitrohydroxymethylmethylamine were toxic to the cells. None of the compounds tested was able to induce selective DNA amplification in the two transformed cell lines. Enzymes involved in drug metabolism were assayed in the hamster cell lines. The activity of UDP-glucuronosyltransferase and cytosolic epoxide hydrolase were not detectable. N-nitrodimethylamine demethylation was low. The content of reduced glutathione and the activities of glutathione transferase and membrane bound epoxide hydrolase were comparable to values obtained in the rat liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400749
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...